1.Correlation between immune regulation and miRNAs in type 1 diabetes
Chinese Journal of Endocrinology and Metabolism 2014;30(5):441-443
It is well established that type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease.Controversial data exist regarding the differential control of the immune system in TI DM.Recent studies have demonstrated that MicroRNAs (miRNAs),single-stranded noncoding RNAs,may play a key role in regulation of gene expression in the immune system.Dicer enzymes or abnormal miRNAs may lead to autoimmune reactions,and thus is expected to become a target for early diagnosis and treatment of T1DM in the future.This article reviews the correlations of known miRNAs with the immune regulation in T1DM and the research progression.
2.Short-term efficacy and safety of concurrent chemoradiotherapy with paclitaxel and lobaplatin for advanced esophageal cancer
Journal of International Oncology 2015;42(1):10-13
Objective To evaluate the short-term efficacy and safety of concurrent chemoradiotherapy (CCRT) with paclitaxel and lobaplatin for advanced esophageal cancer.Methods Sixty-eight patients with advanced esophageal cancer were randomly divided into two groups according to random number table method:CCRT with paclitaxel and lobaplatin (TL group) and CCRT with DDP and 5-Fu (PF group).The CCRT regimen included radiotherapy at a total dose of 60-70 Gy,and concurrent paclitaxel 60 mg/m2 on d1,a fraction per week for 6-8 weeks,lobaplatin 30 mg/m2 on d2,a fraction per 3 weeks (TL group),and concurrent DDP 75 mg/m2 on d1,5-Fu 500 mg/m2,d1-5,CF 200 mg/m2,d1-5 (PF group).Results All 68 patients were evaluable for response.The response rates were 73.53% in TL group and 50.00% in PF group,the median progression-free survival were 13.0 months in TL group and 6.5 months in PF group.There were significant differences (x2 =4.023,P =0.040; x2 =4.512,P =0.034).The incidence rates of Ⅲ-ⅣW degree nausea and vomiting,granulocytopenia and thrombocytopenia were 5.88% and 35.29%,20.59% and 32.35%,32.35% and 8.82%,and the differences were statistically significant (x2 = 8.500,P =0.003 ; x2 =3.200,P =0.041; x2 =6.710,P =0.016).The incidence rates of Ⅲ-Ⅳ degree esophagitis in the two groups were 11.76% and 17.65%,and there was no significant difference (x2 =1.45,P =0.493).Conclusion The efficacy of TL group in the treatment of advanced esophageal cancer is excellent,and all toxicities are well tolerated.So this protocol may be considered a main regimen in the treatment of advanced esophageal cancer.
3.Development of spinal tuberculosis in surgical therapy
Orthopedic Journal of China 2006;0(11):-
For the past few years, incidence of tuberculotic disease inceased stablely, spinal tuberculosis, as the highest incidence of tuberculosis of bones and joints, has been the focus of the orthopedist study. With the development of recognization of spinal tuberculosis and spinal internal fixation technology, the treatment of spinal tuberculosis has been made a great progress, especially in surgical therapy, many new ways have been found in selection of surgical cases, preparation of surgery, surgical skills and surgical postprocessing. Now summarization is made in this paper.
4.Research progress of microRNA in the development of the pancreas and type 1 diabetes
Chinese Journal of Diabetes 2017;25(1):85-87
[Summary] The pathogenesis of type 1 diabetes has not been thoroughly understood. MicroRNA is a kind of small molecule RNA in regulating gene expression at post-transcriptional level. The dysfunction and amount changes of microRNA involve in the regulation of pancreaticβcell volume and function,and thus are related to type 1 diabetes. Here,we reviewed the research advances of microRNA in the development of the pancreas,insulin secretion and type 1 diabetes.
6.Epidemiological characteristics of brucellosis in Zibo City Shandong Province from 2006 to 2014
Ling WANG ; Shuxia YANG ; Tao WANG
Chinese Journal of Endemiology 2015;34(12):905-907
Objective To analyze the epidemiological characteristics and trend of human brucellosis in Zibo.Methods The data of brucellosis was derived from China information system for diseases control and prevention, from the epidemiology case study and outbreak event of brucellosis.Descriptive statistical analysis was used to analyze the incidence, the distribution of time, region and population, the transmission, seropositive rate of vulnerable groups, and the epidemiological characteristics of the cases from 2006 to 2014.Results A total of 541 brucellosis cases were reported between 2006 and 2014, the incidence rates increased from 0.16 per 100 000 to 4.94 per 100 000, and cases were found in about 65% (62/95) of the towns.The disease showed a seasonal cycle with peak period between March and August annually, accounting for 70.61% (382/541) of the total cases.Vocational high risk population were animal keepers, butchers, sellers and producers, accounting for 73.20% (396/541), and foodbome infection accounted for 9.61% (52/541).A total of 8 outbreak events were reported from 2006 to 2014.Conclusions The incidence of brucellosis has increased and the epidemic areas have expanded year by year.Spring and summer are the peak seasons of the disease.Foodborne infection is increasing.
7.Questionnaires on male sexual dysfunction and their clinical application.
Yang CAI ; Tao WANG ; Ji-Hong LIU
National Journal of Andrology 2014;20(9):840-845
With the increasing incidence and prevalence of male sexual dysfunction, andrologists are more and more in need of accurate and efficient tools to assess therapeutic efficacy and patients' satisfaction and to help patients achieve satisfactory treatment results. This article summarizes some of the most commonly used questionnaires for the diagnosis and assessment of the treatment of male sexual dysfunction, including International Index of Erectile Function (IIEF), Erection Hardness Score (EHS), Quality of Erection Questionnaire (QEQ), Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS), Treatment Satisfaction Scale (TSS), Self-Esteem and Relationship (SEAR), Premature Ejaculation Profile (PEP), Premature Ejaculation Diagnostic Tool (PEDT), Index of Premature Ejaculation (IPE), Arabic Index of Premature Ejaculation (AIPE), Aging Male Symptoms Scale (AMS), Androgen Deficiency in the Aging Male (ADAM), and Symptomatic Inventory for Screening Late-Onset Hypogonadism in Males (SILOH), and presents an overview on their clinical application.
Erectile Dysfunction
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Humans
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Male
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Surveys and Questionnaires
8.The value of observation of endometrium and endometrial blood flow of ectopic pregnancy by transvaginal ultrasonography
Tao LI ; Weixiao YANG ; Shuqing WANG
Chongqing Medicine 2001;(2):116-117
Objective In order to predict or exclude early ectopic pregnancy.Methods Endomertrium of 49 early intrauterine and 52 ectopic pregnancy were observed by transvaginal ultrasonography. Trophoblastic artery flow were investigated surrounding the intrauterine embryo or within the endometrium.Results An endometrial three-line pattern resembled late proliferative endometrium of the normal menstrual cycle were seen in 42 ectopic pregnancy(80.8%). An endometrial three-line pattern were not seen in 49 early intrauterine pregnancy. Thirty-nine early intrauterine pregnancy had trophoblastic artery flow surrounding the intrauterine embryo or within the endometrium. None of ectopic pregnancy had trophoblastic artery flow within the endometrium.Conclusion Observation of endometrial three-line pattern and trophoblastic artery flow by transvaginal ultrasonography were useful for diagnosing eraly ectopic pregnancy.
9.Associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility:A meta-analysis
Guofeng WANG ; Kuanfeng XU ; Tao YANG
Chinese Journal of Diabetes 2015;(2):110-114
Objective To explore the associations between polymorphisms of Vitamin D receptor gene and type 1 diabetes susceptibility. Methods Literatures were retrieved from PubMed ,Web of Science and WanFang databases ,etc.Pooled odds ratios(ORs) with 95% confidence intervals (CIs) were calculated using a random effect model. Results A total of 28 literatures were included. The result of analysis showed that BsmI and ApaI polymorphism were the susceptibility gene for T 1DM in Asian populations [B vs b;OR(95% CI)=1.53(1.06~2.20) ,P=0.024 ;AA vs aa:OR(95% CI)=1.60(1.06~2.40) ,P= 0.023]. Conclusion The BsmI and ApaI polymorphism may be susceptibility gene in Asians populations with T1DM.
10.Professor T ian Cong-huo’s commonly used acupuncture methods and their clinical application
Tao YANG ; Rui WANG ; Hong ZHAO
Journal of Acupuncture and Tuina Science 2015;(2):74-82
To introduce Prof. T ian Cong-huo’s commonly used acupuncture methods and their clinical application, in order to summarize the famous doctor’s experience, promote the experience inheritance of Chinese acupuncture, and enhance the therapeutic effect of acupuncture.