Objective To study the effect of acarbose on vascular endothelial function in patients with impaired glucose tolerance (IGT).Methods Fifty-six cases with IGT were chosen by OGTT,and they were divided into control group(27 cases) and therapy group(29 cases) by systematic sampling.The patients in control group were received placebo,the patients in therapy group were given acarbose 25-50 rug,3 times daily for 12 weeks.The body mass index (BMI),blood fat,fasting blood glucose (FPG),fasting insulin (FINS),glycosylated hemoglobin (HbA1c),high sensitivity C-reactive protein (hs-CRP),von Willebrand factor (vWF),2 h post-meal glucose (2hPG),2 h post-meal insulin (2hINS) and brachial artery endothelium-dependent dilation (EDD) was detected before and after treatment in two groups.Results Compared with that before treatment,BMI,2hPG,2hINS,HbA1c,hs-CRP and vWF were decreased and brachial artery EDD was improved after treatment in therapy group[ (24.69 ± 2.62) kg/m2 vs.(22.02 ± 2.59)kg/m2,(9.26 ± 1.02) mmol/L vs.(7.43 ± 0.95) mmol/L,(42.17 ± 9.98) U/L vs.(34.76 ± 9.86) U/L,(6.03 ±0.67)％ vs.(5.37 ±0.56)％,(5.45 ± 1.93) mg/L vs.(4.52 ± 1.55) mg/L,(187.22 ±26.57)％ vs.(165.13 ± 23.86)％,(6.08 ± 1.22)％ vs.(7.94 ± 1.25)％ ] (P ＜ 0.05 or ＜ 0.01).There was no significant difference before and after treatment in control group (P ＞ 0.05).Conclusion Acarbose can improve brachial artery EDD in patients with IGT by increasing insulin sensitivity and decreasing postprandial hyperglycemia and inflammatory factor,which delays the progression of diabetic mellitus and atherosclerosis.

Choroidal neovascularization( CNV) is a common severe complication of ocular fundus diseases, with great potentiality to cause blindness. The treatments of CNV include photodynamic therapy ( PDT ) and anti-vascular endothelial growth factor( VEGF) therapy. However, PDT produces little visual benefits, and may result in ischemia, inflammatory responses, even the secondary expressions of VEGF. Anti-VEGF therapy sustained visual efficiency by repeated injections, causing economic burden and adverse effects related to injection. Recently, PDT combined with anti-VEGF therapy has progressed in laboratory and clinical research. Therefore, the combined modality therapy became one of the treatment options for CNV. In order to reduce the side effects of mono -therapy, further study is required to determine appropriate combinations and dosage.

Asthma ; Humans ; Hygiene ; Hygiene Hypothesis ; Hypersensitivity

This article discusses the necessity of the informatization construction and information of traditional Chinese medicine and its position and function in scientific research.Then from six aspects of infrastructure construction,information resource construction,information technology support,information personnel training,information and laws and regulations environment,and information resources product,this paper expounds the major tasks and constructive emphasis in each phase of scientific research informatization construction.Finally,this paper summarizes the prospect of TCM scientific research information construction and its role to the development of Chinese medicine.

B ased on Chinese medicine pharmacological literature data , the property , flavor , toxicity , meridian tropism, efficacy, and clinical application of Chinese herbal medicine were used as a set of attributes. The sup-port vector machine ( SVM ) was used in the establishment of predictive models of 187 pharmacological effects of Chinese herbal medicine respectively. And the cross-validation method was used to determine the accuracy of predictive models . After that , the predictive models with the predictive accuracy rate greater than 90% were used to predicate pharmacological effects of 624 herbals recorded in the Chinese Pharmacopoeia(2010 edition). It was found that the accuracy rate of 108 models was greater than 90%, and the accuracy rate of antibacterial effect predictive model was 99.76%. The highest predictive value of Chinese herbal medicine was the anti-oxi-dation effect of Menispermi Rhizoma.

In recent years,research on autoimmune pancreatitis (AIP) has gained significant progress.AIP is a special type of chronic pancreatitis which is mediated by an autoimmune mechanism.It is characterized by the infiltration of lymphocytes and plasma cells leading to pancreatic fibrosis and dysfunction.AIP can affect the bile ducts,salivary glands,kidneys and other organs outside the pancreas.The common manifestations include obstructive jaundice,abdominal pain,and weight loss,which are similar to pancreatic cancer.Steroid therapy is of significant effect.There is no consensus nowadays on the diagnostic criteria of AIP across the world.There are many studies on the pathological subtypes,imaging,serological markers and biopsy techniques on AIP,and research focuses on the differential diagnosis from pancreatic cancer.

Objective To validate the accuracy of the revised Atlanta classification (RAC) and the determinant-based classification (DBC) for severity of acute pancreatitis.Methods We retrospectively analysed the clinical data from 192 patients with acute pancreatitis who were admitted to our hospital between January 2014 and October 2014.Using the RAC and the DBC,The duration of total parenteral nutrition,length of ICU and hospital stay,operation rate and mortality were assessed in the subgroups,respectively.Results Fluid collections in and around the pancreas was present in 74 patients (38.5％),pancreatic or peripancreatic necrosis in 51 (26.6％),and infection in 18 (9.4％).On the basis of the RAC,106 patients (55.2％),77 patients (40.1％),and 9 patients (4.7％) were classified to have mild,moderately severe,or severe AP,respectively.On the basis of the DBC,11l (57.8％),62 (32.3％),14 (7.3％),and 5 (2.6％) patients were classified to have mild,moderate,severe,or critical AP,respectively.The different categories of severity for each classification system were significantly associated with the duration of total parenteral nutrition,the length of ICU and hospital stay,the operation rate and mortality.Conclusion Both the RAC and DBC accurately classified the severity of AP and differentiated prognosis in the subgroups of patients.

Objective To discuss the diagnostic value of serum cystatin-C(Cys-C) and urinary retinol binding protein(RBP) for the early renal impairment in multiple myeloma(MM) patients .Methods According to estimated glomerular filtration rate(eGFR) , the MM patients were divided into two groups :the normal renal function group(eGFR≥90 mL/min ,n=78)marked group A ,the renal impairment group(eGFR<90 mL/min ,n=40)marked group B .130 healthy subjects were selected as control group .The con-centrations of serum Cys-C ,urinary RBP ,serum creatinine(Cr) and serum urea nitrogen(UN) were measured and compared .Results The levels of Cys-C and RBP in group A were significantly higher than those in the control group(P<0 .01) .There were signifi-cant difference of the levels of Cys-C ,Cr ,UN and RBP levels between group B and control group(P<0 .01) .The sensitivity of the combined detection of Cys-C and RBP was 57 .69% ,significantly higher than single index test(P<0 .05) .Conclusion Compared with traditional biomarkers ,Cys-C and RBP are more sensitive and effective indexes for the diagnosis of early renal impairment in the patients with MM ,and jointed detection of the two biomarkers has important value .

Objective To summarize the experience of nursing cancer patients with anal fistula treated with blood stem cells transplantation (BSCT). Method 8 critical cancer patients with anal fistula treated with BSCT from August 2013 to November 2014 were intervened by nursing measures such as prevention of constipation and diarrhea , protecting the anus from infection and health education . Results Two patients of them contracted with mild crissum infection , 1 moderate , 0 severe . With the pertinent nursing intervention , no serious complications occurred . The hospital stay was 20~30 d , with an average of ( 24 . 75 ± 2 . 30 ) . Conclusion The nursing measures including preventing constipation and diarrhea, keeping the anus from infection and health education can be effective in avoiding anal fistula infection and its related complications and reducing patients′pain , which are worth clinical promotion .

Objective To study the possible pathogenesis of TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced inflammatory bowel disease (IBD) in a mouse model by analyzing histological changes in colon and the expression of cytokines and transcription factor RORγt related to T cell subsets in mesenteric lymph nodes.Methods Female BALB/c mice aged 6-8 weeks were randomly grouped into two groups: IBD model and normal control groups.The mouse model of IBD was established by treating mice with 200 μl of 5％ TNBS/50％ ethanol solution (1∶1) through intestinal instillation, while the mice in the normal control group were instilled with PBS.Pathological changes in colon samples of mice were observed.Real-time PCR was performed to detect the dynamic expression of Th1 cytokines (IL-2, IFN-γ and IL-12p40), Th2 cytokine (IL-4), Treg-related cytokine (IL-10), Th17 cell-related cytokines (IL-17, IL-21 and IL-23) and transcription factor RORγt in mesenteric lymph nodes.Results The mice in the model group begun to show abnormal vital signs such as diarrhea, loss of weight and reduced activity, and mild hyperemia of intestinal mucosa and edema from the third day after modeling.Slight lesions were observed in histological slices of colon tissues stained with hematoxylin and eosin (HE).The expression of IL-21, IL-23 and IL-17 at mRNA level were significantly increased, while the expression of other cytokines showed no significant change.On the sixth day after modeling, many pathological symptoms and intestinal mucosal lesions were aggravated, and marked infiltration of inflammatory cells was observed in histological slices of colon tissues, which indicated that the IBD model was successfully induced by TNBS.Compared with the control group, the IBD model group showed significantly enhanced expression of IL-2, IL-12p40 and IL-10 in mesenteric lymph nodes at mRNA level on the sixth day after modeling.Although the expression of IL-21, IL-23, IL-17 and RORγt at mRNA level on the sixth day were down-regulated to different extent as compared with those on the third day, they were still significantly higher than those of the control group.Conclusion Th17 cell-related cytokines play an important role in the early stage of TNBS-induced IBD.With the progression of the disease, both Th1 and Th17 cells are involved in the immunopathological injury of colon tissues.