1.Blocking Action of Nicardipine on alpha1-Adrenoceptors in Circulatory System of Rabbit.
Chang Il KIM ; Yang Kyu PARK ; Ock Kyu PARK ; Bong Kyu CHOI
Korean Circulation Journal 1991;21(3):546-555
To investigate relationship between alpha1-acrenoceptors and nicardipine, an 1,4-dihydropyridine calcium antagonist, effects of nicardipine, on phenylephrinne(PE)-induced vasoconstriction in isolated arterial rings and pressor response of rabbits were observed. In normal physiological salt solution(NPSS), 35mM KCI produced persistent contractions of thoracic aorta and carotid artery and the contractions were dose-dependently inhoboted by cumulative admini-stration of nicardipine in the range of doses from 10(-10)M to 10(-4)M, IC50s of nicardipine in the thoracic aorta and carotid artery were 3.3x10(-7)M and 4.6x10(-7)M, respectively and there was no difference between both values. Constant contractions induced by 10(-5)M PE in both rings were inhibited by the same doses of nicardipine in a dose-dependent fashion. The IC50s were 2.8x10(-4)M in thoracic aorta and 2.9x10(-5)M in carotid artery respectively, and the former was about 10 times greater than the latter. In Ca2+ free PSS, KCI did not produce any contractionn. Though constant and reproducible in NPSS, PE-induced contraction was transient and not reproducible in Ca2+ free PSS. The contraction in both rings were weakened to about 70% of those in NPSS. Pretreatment with nicardipine in the range of doses from 10-8M to 10-5M hardly affected the PE-induced contraction and the largest dose 10(-4)M slightly inhibited the contraction. Intravenous injection of nicardipine 10 to 1000microg/kg decreased blood pressure and heart rate of rabbits in a dose-dependent manner. The % decrease of heart rate was much smaller in comparison with the %decrease of blood presseure. Pressor effect of 30microg/kg PE was dose-dependently inhibited after treatment with nicardipine 10 to 1000microg/kg and ID50 was 314microg/kg(6.1x10(-7)mole/kg). Above results suggest that nicardipine blocks extracellulr Ca2+ influx by membrane depolarization and in a part by alpha1-adrenceptors, then relaxes arterial smooth muscles in rabbits.
Aorta, Thoracic
;
Blood Pressure
;
Calcium
;
Carotid Arteries
;
Heart Rate
;
Inhibitory Concentration 50
;
Injections, Intravenous
;
Membranes
;
Muscle, Smooth
;
Nicardipine*
;
Rabbits
;
Vasoconstriction
2.Internal mammary artery grafting without intraluminal dilatation.
Jong Bum CHOI ; Jae Do YOON ; Yang Kyu PARK ; Ok Kyu PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(3):307-314
No abstract available.
Dilatation*
;
Mammary Arteries*
;
Transplants*
3.Earlyclicical result of coronary artery bypass surgery for ischemic heart disease.
Jong Bum CHOI ; Huung Kon KIM ; Tae Geun RIM ; Yang Kyu PARK ; Ok Kyu PARK
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(4):271-275
No abstract available.
Coronary Artery Bypass*
;
Coronary Vessels*
4.Changes of segmental left ventricular wall motion after coronary artery bypass graft surgery ; two-dimensional echocardiographic study.
Soo Yeon WON ; Il Mun JEON ; Myoung Seon PARK ; Myoung Kyu JANG ; Jae Kyu RYU ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK ; Jong Bum CHOI
Korean Journal of Medicine 1993;45(6):770-780
No abstract available.
Coronary Artery Bypass*
;
Coronary Vessels*
;
Echocardiography*
5.Histiocytosis X with Involvement of Pituitary Stalk: Case Report.
Byung Kyu CHO ; Kyu Chang WANG ; Sei Won YANG ; Je G CHI ; In One KIM ; Kil Soo CHOI
Journal of Korean Neurosurgical Society 1989;18(7-12):1098-1102
A case of histiocytosis X with the involvement of pituitary stalk in a 5 year old boy was described. He presented with diabetes insipidus and the endocrinological study showed growth hormone deficiency. On computerized tomography and magnetic resonance imaging, the pituitary stalk was abnormally thick. Overlooking of the skull lesion on plain X-ray film led to an erroneous diagnosis of germ cell tumor'. Gross total removal of the lesion and chemotherapy were performed. In the differential diagnosis of suprasellar masses, this disease entity should be included. The importance of histological diagnosis of the infundibular lesion in cases of central diabetes insipidus is also emphasized.
Child, Preschool
;
Diabetes Insipidus
;
Diabetes Insipidus, Neurogenic
;
Diagnosis
;
Diagnosis, Differential
;
Drug Therapy
;
Germ Cells
;
Growth Hormone
;
Histiocytosis*
;
Histiocytosis, Langerhans-Cell*
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Pituitary Gland*
;
Skull
;
X-Ray Film
6.Treatment of aplastic anemia.
Nak Gyun CHUNG ; Kyu Jin BHAN ; Woo Gun CHOI ; Hack Ki KIM ; Kyong Su LEE ; Man Kyu YANG
Journal of the Korean Pediatric Society 1993;36(8):1059-1066
We performed this study to evaluate the therapeutic responses of bone marrow transplantation and immunosuppressive therapy for aplastic anemia in 103 cases (68 severe and 35 moderate). Among them, 15 cases with severe aplastic anemia having HLA-identical sibling donor underwent bone marrow transplantation, and cases(53 severe and 35 moderate cases)without available HLA-identical sibling donor had received immunosuppressive therapy using antilymphocye globulin and cyclosporin-A. The results were as follows; 1) For cases given bone marrow transplantation, successful engraftment was accomplished in all cases, but 2 cases showed rejection and 1 case died of thrombotic thrombocytopenic purpura (TTP), resulting 80% disease-free survival rate. acute graft-versus-host disease above grade II was noted in 2 cases and chronic graft-versus host disease was seen in other 2 cases. The most common pathogenic organism in post-transplantation infection was Herpes zoster (6 cases), and one each cases of Herpes simplex, candidiasis, measles and hemorrhagic cystitis developed. 2) Among 88 cases of receiving immunsouppressive therapy, complete response was seen in 26 cases (29.5%) and partial respones in 37 cases (42.0%), resulting 71.6% of overall response rate and recurrence rate was 19.5% (12 cases). In 53 severe cases, complete response was seen in 9 cases (17.0%) and partial response in 25 cases (47.2%), resulting 64.2% of overall response rate. In 35 moderate cases, complete response was seen in 17 cases (48.6%) and partial response in 12 cases(34.3%), overall response rate was 82.9%. All initial responses were seen within 6 months post-treatment period, and the time interval to initial response was 8 to 162 days (median; 53 days). There was no sex difference concerning response rate, however, partial response was predominant in male and more complete response in female. The complications of immunosuppressive therapy were thrombocytopenia (93.2%), fever (67.7%), hypertension (50.0%), skin eruption (45.8%), gingivitis (17.0%). In conclusion, our date suggest that bone marrow transplantation is preferred initial treatment modality to immunosuppressive therapy in severe aplastic anemia patient with HLA-identical sibling donor, and immunosuppression is a satisfactory alternative therapy for children with severe aplastic anemia in the absence of HLA-identical sibling and for whom with moderate aplastic anemia.
Anemia, Aplastic*
;
Bone Marrow Transplantation
;
Candidiasis
;
Child
;
Cystitis
;
Disease-Free Survival
;
Female
;
Fever
;
Gingivitis
;
Graft vs Host Disease
;
Herpes Simplex
;
Herpes Zoster
;
Humans
;
Hypertension
;
Immunosuppression
;
Male
;
Measles
;
Purpura, Thrombotic Thrombocytopenic
;
Recurrence
;
Sex Characteristics
;
Siblings
;
Skin
;
Thrombocytopenia
;
Tissue Donors
7.Transcervical GIFT & ZIFT by tactile sensation.
Young Bum CHA ; Jong Min PARK ; Seung Jae LEE ; Kyu Wan CHOI ; Hyun Won YANG ; Hee Kyu KANG
Korean Journal of Obstetrics and Gynecology 1993;36(5):634-639
No abstract available.
Sensation*
;
Zygote Intrafallopian Transfer*
8.A Case of Extra-Adrenal Pheochromocytoma with Abdominal Colic and Paroxysmal Hypertension.
Jeong Seong KANG ; Soo Yeon WON ; Il Mun JEON ; Myoung Kyu JANG ; Suck Chei CHOI ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1993;23(4):621-624
Pheochromocytomas can arise wherever chromaffin cells are found, and most of them(90%) are in one or both adrenal glands. But they may be located anywhere along the sympathetic chain and rarely in aberrant sites. One of the common extra-adrenal sites from which these tumors can arise is a collection of para-aortic and para-ganglion cells around the origin of the inferior mesenteric artery. We experienced a case of extra-adrenal pheochromocytoma located at the organ of Zukerkandl in a 21-year-old female patient with abdominal colic and paroxysmal hypertension, whose symptoms and blood pressure returned to normal after successful surgical excision of the tumor.
Adrenal Glands
;
Blood Pressure
;
Chromaffin Cells
;
Colic*
;
Female
;
Humans
;
Hypertension*
;
Mesenteric Artery, Inferior
;
Pheochromocytoma*
;
Young Adult
9.A Case of Adrenal Cyst.
Yang Suk CHOI ; Kyu Young YEUM ; Do Whan AHN
Korean Journal of Urology 1986;27(2):277-281
Adrenal cyst is a rare pathologic lesion in all patients which can pose difficult problems in terms of diagnosis and treatment. Most are small and found incidentally on autopsy. We report one case of a large adrenal cyst in a 54-year- old female with review of the literature.
Autopsy
;
Diagnosis
;
Female
;
Humans
10.A Case of Virilizing Adrenal Cortical Carcinoma.
Seung Chul YANG ; Jin Wook CHOI ; Moon Young SONG ; Byung Kyu SUH ; Byung Churl LEE
Journal of Korean Society of Pediatric Endocrinology 1997;2(2):248-254
Adrenal cortical carcinoma is a rare disease both in adults and in children. Most of these tumors are functional, especially in children, producing endocrine syndromes such as virilization, Cushing syndrome, hyperaldosteronism or feminization. We experienced a case of adrenal cortical carcinoma in a 7yr old boy who showed features of virilization such as rapid growth rate, penile enlargement, and pubic hair. This case was diagnosed with typical hormonal findings and abdominal MRI and confirmed by pathologic findings. He was successfully treated by total left adrenalectomy and has been followed up without problem over eight months.
Adrenalectomy
;
Adrenocortical Carcinoma*
;
Adult
;
Child
;
Cushing Syndrome
;
Feminization
;
Hair
;
Humans
;
Hyperaldosteronism
;
Magnetic Resonance Imaging
;
Male
;
Rare Diseases
;
Virilism