The paper analyzes the urgency of constructing the medical information consulting service system in big data era as well as the features of the system,describes the architecture of the system from the perspectives of function,process relation and technology,introduces the construction of the mobile clients of the system,discusses the promotion and application of mobile clients.

Biological ultrasonic (US),photoacoustic (PA) and magnetoacoustic (MA) imaging techniques had similar imaging principles and complementary characteristics.Combined US,PA or MA imaging can provide joint images of biological tissues which present complementary information for more comprehensive characterization of tissues in contrast to single imaging technique.The pathological tissues could be precisely located and their morphology and composition could be accurately identified.This review presented current progresses in combined PA-US,MA-US and US-PA-MA imaging techniques,espeically endoscopic imaging,focusing on the technical aspects of integration and their applications in biomedicine.

Objective To investigate the incidence of drug resistance among new and retreatment TB patients from special hospital.Methods Totally 500 smear positive TB patients from June 2013 to December 2014 in Beijing Chest Hospital were enrolled.Phenotypic susceptibilities to cultured isolates were analyzed in 15 anti tuberculosis drugs by MGIT 960,include Isoniazid (INH),Rifampicin (RFP),Streptomycin (STR),Ethambuto (EMB),Kanamycin (Km),Amikacin (Am),Capreomycin (Cm),Ofloxacin (Ofx),Levofloxacin (Lfx),Moxifloxacin (Mfx),Paza-aminosalicylate (PAS),Protionamide (Pto),Linezolid (Lzd),Ethionamide (Eto),Pyrazinamide (PZA).Results A total of 500 TB cases were enrolled.71 samples among these were NTM infection and 12 samples were contaminted.The rest of 417 of cases infected with Mycobacteriuma,and the rate of drug resistance was 47.2％ (192/417) and the MDR rate was 28.2％ (120/417).The retreatment was significantly higher than that of the new in any drug resistance rate and MDR rate (P =0.000).100 of the retreatment isolates and 50 of the new isolates with Mycobacteriuma were selected to do the drug susceptibility test in 11 subsequent anti tuberculosis drugs (include:PZA,Am,Km,Cm,Ofx,Lfx,Mfx,PAS,Pto,Lzd,Eto).Five cases were contaminated,and in the rest of the cases,48 was the new and 97was the retreatment.The rate of the drug resistance to PZA,Am,Km,Cm,Ofx,Lfx,Mfx for the retreatment were significantly higher than the new (P ＜ 0.05).The rate of drug resistance to PAS,Pto,Lzd and Eto for the new and reteartment were no markedly differential in statistics.Conclusion This study further confirmed the rate of drug resistance in retreatment cases is higher,and the management of tuberculosis patients should be further strengthened.

Objective To investigate the amide proton transfer (APT) values in basal ganglia of neonatal piglet hypoxicischemic brain injury (HIBI) model using MR APT imaging.Methods Totally 35 healthy neonatal piglets were selected.There were 5 piglets underwent sham-operation in control group and 30 piglets used to established HIBI models in HIBI group.According to the time interval between APT imaging and the establishment of HIBI model,the piglets in HIBI group were divided into 0-＜2 h,2-＜6 h,6-＜12 h,12-＜24 h,24-＜48 h and 48-＜72 h subgroups.APT imaging was performed on all piglets.The APT value of basal ganglia between control group and all the subgroups in HIBI group were compared.Results After HIBI occurred,the APT values immediately decreased in 0-2 h,and then increased gradually.In 24 h after HIBI,the APT values were mainly returned to the level of control group,then continuously increased.The APT value in control group and 0-＜2 h,2 ＜6 h,6 ＜12 h,12-＜24 h,24-＜48 h,48-＜72 h subgroups in HIBI group were 0.52 ± 0.09,-0.35 ± 0.08,-0.02 ± 0.14,0.28± 0.04,0.46 ± 0.11,0.80 ± 0.11,1.24 ± 0.18,respectively.The APT values between control group and each subgroups in HIBI group had significant differences (all P＜0.01) except for 12-＜24 h subgroup (P=0.68).Conclusion The APT value decreased firstly and then increased after HIBI in neonatal piglet.APT imaging can provide a non-invasive molecular MR method to evaluate the pathophysiological changes of HIBI.

Objective:To improve the prediction of the resectability of esophageal carcinoma by computed tomography.Methods:Eighty-five esoghageal carcinoma cases diagnosed by conventional upper GI tract radiography were enrolled.Three CT signs i.e. angularity,triangular area,and angularity combined with posture were used to observe and to determine the >45。Results:The prediction of resectability by CT were accurate which was confirmed by surgical interventions.Conclusion:Determination of the triangular fat pad between the aorta and the tumor lesion by Ct is reliable and practical in the predication of resectability in the patients with esophageal carcinoma.

In this article,we explained the pathogenesis of bony paralysis,‘disharmony between bone and muscle',recorded in Huangdi NeiJing,by researching the dependability between bone and muscle both in traditional Chinese medicine and modem medicine.

ObjectiveTo explore the expression of Smad2 in cervical carcinoma and analyze the clinical significance of Smad2.MethodsThe expression of Smad2 in normal uterus group( NE group,n =61 ) and cervical carcinoma group( CC group,n =53 ) were detected by immunohistochemistry to analyze the significance of Smad2 in the cervical carcinoma.ResultsPositive rate of expression of Smad2 protein in NE group was 39.3％,positive rate was 77.4％ in CC group,statistical difference was found between the two groups(P ＜ 0.01 ).The degree of differentiation of cervical cancer was lower,and the Smad2 positive rate was higher,well-differentiated and poorly differentiated were 52.6％ and 91.2％,respectively,and the difference was statistically significante ( P ＜ 0.01 ) ; The invasion of cancer was higher,and the Smad2-positive rate was higher ≤ 1/2 and ＞ 1/2 were 66.7％ and 91.3％,respectively,and the difference was statistically significante ( P ＜ 0.05 ).ConclusionThe expression of Smad2 was less; Smad2 was related to depth of invasion and degree of differentiation of cervical carcinoma,which could be used as clinical diagnosis and prognostic markers.

Objective To evaluate the preoperative diagnostic procedures and treatment choice of primary tumor of the duodenum (PTD).Method The clinical data of 52 cases with PTD in the last 10 years was analyzed retrospectively.Results The correct diagnostic rate of auxiliary examination was:duodenal endoscopy of 90.5%,air barium double radiography of 80%.Six primary benign tumors of duodenum (PBTD)were resected completely with a 5 year's survival of 100%.Among the 46 cases of primary malignant tumors of duodenum (PMTD),28 cases underwent pancreatoduodenectomy,4 cases received segmental duodenectomy,the remaining 13 cases in which the tumors were unresectable were treated bypass.The resection rate was 69.6% and the 5 years' survival rate was 32.6%.Conclusions Duodenal endoscopy and air barium double radiography are mainstays for the diagnosis of PTD.Segmental duodenectomy and simple tumor resection are curable for PBTD; while for PMTD,the therapy of choice should be pancreatoduodenectomy.

Histone acetylation and deacetylation is an important regulatory way of gene expression in eukaryotic cells. As a key regulatory enzyme, histone deacetylase is overexpressed in many malignant tumors, including hepa- tocellular carcinoma. In addition, it has been suggested to be a potential therapeutic target for solid tumors. In this study, we review the classification, mechanisms, as well as the expression and regulation of histone deactylases in hepatocelhlar carcinoma.

Expansive type of hepatocellular carcinoma (HCC) is a subtype of HCC. Correlation between the preoperative sonography and postoperative pathology was studied in 35 cases of HCC. According to the classification of nakashima, 21 cases belonged to the expansive type whereas the other 14 cases the infiltrative type. Different from the infiltrative type. the expansive type of HCC had four specific sonographic appearances: hypoechoic ring, hypoechcic halo, pedunculated and small nodular echo which had different pathological bases. Expansive tyje of HCC was not so commonly seen as infiltative type but its rate of surgical resection was mu~h higher than that of infiltratine type (JP< 0. 01). Thus, it is the kind of HCC with significant clinical importance. Preoperative ultrasonographic diagnosis help to decide the way of treatment.