Behcet Syndrome ; Child ; Humans ; Intestinal Diseases ; Male

The paper analyzes the impact of MOOC on medical information resources construction,and proposes the response strategies for the information resources construction of medical library,including introducing Patron Driven Acquisitions (PDA) mode,strengthening digital resources construction efforts,developing medical MOOC course reference resources system and constructing medical library alliance.Meanwhile,it points out that the medical library is required to dig users'information demand further and solve the issue of MOOC copyright clearance.

The blood gases and acid-base disorders were analysed in 276 cases with chronic cor pulmonale at 2260m above sea level (Xining). The results demonstrated that: (1) the incidence of acid-base disorders, respiratory acidosis and the ratio of compensatory to decompensatory respiratory acidosis were low, the rate of respiratory alkolosis was high, if they were evaluated according to the formula used on plains. If normal values determined in Xining were used, the various incidences were about the same as observed on plains. (2) In diagnosing respiratory failure with blood gas analysis if the criteria commonly employed on plains was applied, the incidence of type J respiratory failure was higher, and that of type I was lower. If PaO25.33kPa were used as the criteria for respiratory failue, the incidence of type I respiratory failure became lower with type Ⅱ higher. The characteristics of acid-base disorders and diagnostic criteria of respiratory failure in patients with cor pulmonale were discussed.

Objective To analyze the CT characteristic of pulmonary inflammatory mass and peripheral lung cancer, and to look for the method of diagnosis solitary pulmonary nodule. Methods 28 patients of pulmonary inflammatory masses and 33 patients of peripheral lung cancers were included in the study,all patients conformed by pathology. The lesions were divided into typical and atypical masses according to morphology. Observing the signs of lesions and using the results ameliorate the morphological classification. Tested the method by ROC. Results According to the standard of morphology, the diagnosis sensitivity, specificity and accuracy of inflammatory mass are 64.3%, 72.7% and 68.9% respectively. The ameliorated sensitivity, specificity and accuracy are 75%, 81.8% and 78 7% respectively. Conclusion The method of making morphology as basement and sign as supplement can improve the sensitivity, specificity and accuracy of diagnosis.

Aim To investigate the inhibition mechanisms of baclofen, a specific GABA B receptor agonist, on quantal glutamate release in the rat spinal dorsal horn neurons.Methods Whole-cell voltage-clamp technique was performed on dorsal horn neurons in rat spinal cord slice to record glutamatergic spontaneous miniature excitatory postsynaptic currents (mEPSCs). Baclofen action on quantal glutamate release was assessed by analyzing the change of mEPESC to baclofen perfusion.Results Baclofen(10 ?mol?L -1,50 s) depressed the frequency, but not amplitude distribution of glutamatergic mEPSCs, indicating baclofen presynaptic depression on glutamate release. The depression on frequency of mEPSCs persisted in Ca 2+-free solution, or in the presence of K + conductance blocker, 4-AP. On the other hand, the depression was occluded by forskolin, an activator of adenylate cyclase, but not protein kinase C (PKC) activator phorbol 12,13-dibutyrate (PDBu). N-ethylmaleimide (NEM), a sulphydryl alkylating agent, which destroys G protein, abolished baclofen depression.Conclusion Not presynaptic K +, Ca 2+ conductance or PKC, but G protein and/or cAMP pathway are involved in the baclofen depression on glutamate release in rat spinal dorsal horn;this depression might contribute to the analgesic action of baclofen at spinal level.

Post-resuscitation multiple organ dysfunction syndrome(PR-MODS) is a major cause of low survival rate in patients with cardiac arrest.To fully understand the concept of PR-MODS is beneficial for estimating the state of illness,adjusting the therapy and eventually increasing the survival rate.This article reviews the development of PR-MODS concept and compares it with MODS of other causes,including their pathogeny,pathology,mechanism,diagnosis and therapy.

The traditional acupuncture and moxibustion therapies were adopted to treat 32cases of melanoderm's peripheral facial paralysis at remission stage, the effective rate was 93.8%, indicating that acupuncture and moxibustion therapies are effective for different races.

Objective To explore the mechanism of the cumulative biological effect of acupoint laser radiation and investigate its analgesic effect by comparing the therapeutic effects of semiconductor laser radiation versus acupuncture at point Zusanli(ST36) in acute adjuvant arthritis rats and to provide the experiment-based theoretical foundation and basis for the course of treatment of acute arthritis pain by clinical use of semiconductor laser. Method A rat model of AA was made by subcutaneous injection of complete Freund's adjuvant into rat toe. Eighty rats were randomly allocated to eight groups:model, blank, three-day laser radiation, five-day laser radiation, seven-day laser radiation, three-day acupuncture, five-day acupuncture and seven-day acupuncture treatment groups, 10 rats each. The three laser groups separately received 650 nm semiconductor laser radiation. The three acupuncture groups separately received acupuncture with a filiform needle at point Zusanli(ST36) on the inflammation-affected side. Rat general condition, body weight, pain threshold value and ankle swelling degree were observed. Serum inflammatory factors IL-1、TNF-αand IFN-γcontents were measured by ELISA. Result There were statistically significant posttreatment differences in body weight, joint swelling degree and pain threshold between the laser treatment and acupuncture treatment groups of rats (P<0.05). There was a statistically significant post-treatment difference in joint swelling degree between three-day laser, five-day laser and seven-day laser treatment groups (P<0.05). Pain threshold was lowest at five days after treatment and increased somewhat at seven days after treatment in both the three-day laser and three-day acupuncture treatment groups. The IL-1 content tended to decrease on the whole and had a decreasing tendency at three and five days after treatment in both laser and acupuncture treatment groups. At seven days after treatment, it reached the lowest value in the laser treatment group but had a marked increasing tendency in the acupuncture treatment group. The IFN-γcontent had an increasing tendency at three and five days after treatment in both laser and acupuncture treatment groups. The IFN-γcontent tended to change gently in the laser treatment group from day five to seven after treatment. It tended to decrease from day five to seven after acupuncture treatment but was still higher than in the three-day acupuncture treatment group. The TNF-αcontent tended to decrease from day three to five after treatment in both laser and acupuncture treatment groups. From day five to seven after treatment, it tended to decrease gently in the laser treatment group but tended to increase slightly in the acupuncture treatment group. Conclusion Both semiconductor laser radiation and acupuncture at point Zusanli have an anti-inflammatory and analgesic effect and can relieve the general symptoms in AA rats, but semiconductor laser radiation is significantly superior to acupuncture treatment in eliminating inflammation and easing pain and produces a more timely and better therapeutic effect. After semiconductor laser radiation at acupoints, the related serum cytokines tended to increase or decrease slowly in AA rats after the turning point appeared during the treatment, which embodies the parabola feature of laser radiation treatment. It is showed that with an increase in laser radiation length, the biological effect of laser accumulates, suggesting that attention should be paid to the cumulative effect during laser treatment.

Objective To compare the difference between the short stature and normal boys testicular vol-ume,and to investigate the relationship between the short stature and testicular development.Methods Testicular testing for 70 cases of short stature by color doppler ultrasound from 4 to 12 years old,calculation of testicular volume average(MVT),references for the boy normal testicular volume provided by Peking union medical college hospital and the Beijing children's hospital,compared the above two groups.The short stature's height,weight,body mass index (BMI)for correlation analysis.Results The MVT of the short stature group were lower than normal,compared with the normal group differences statistically significant(P<0.05);The weight,BMI,MVT of idiopathic short stature had a tendency to decrease compared with complete lack of growth hormone deficiency from 10 to 12 years old;The short stature's height had low relativity with MVT(r=0.393,P=0.01 ),the weight had middle relativity with MVT(r=0.508, P<0.01),and the BMI had low relativity with MVT(r=0.352,P<0.01).Conclusion The testicular development of short stature is relatively slow,which should make early intervention for the gonad development of short stature.

Pulmonary asthenia is one of the chronic consumptive lung diseases because of the weakness of pulmonary lobe. It would be the outcome of many chronic lung diseases with poor prognosis. In recent years, preventing and treating pulmonary asthenia by traditional Chinese medicine (TCM) has been one of the research focuses and some fruits have been received. This paper summarized pulmonary asthenia from the aspects of etiology and pathogenesis, syndrome differentiation, TCM treatment so as to provide theoretical basis and proofs for treatment of pulmonary asthenia by TCM.