Sepsis,a common clinical syndrome,comparing to septicaemia or bacteremia,has a more comprehensive pathophysiological process.Its pathogenesis is complex,including pro-inflammatory/anti-inflammatory cytokine imbalance,intestinal bacterial translocation,immunosuppression,signal pathway activation,etc.Further study on the pathogenesis of sepsis is the theory foundation to explore the new method of sepsis.The diagnosis of sepsis pathogenesis,treatment principles and common virus infection induced sepsis are reviewed in this paper.

Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; drug therapy ; Humans ; Phytotherapy ; methods ; trends

Objective To observe and explore the risk factors of nonalcoholic fatty liver diseas(NAFLD) complicated with hypertension in the enterprise retirees .Methods A total of 209 NAFLD patients diagnosed by ultrasound combined with questionnaire were collected in the enterprise retirees,and they were divided into the NAFLD with hypertension group(100 cases)and NAFLD without hypertension group (109 cases)after combined with physical examination results and past medical history.The relevant data of the two groups were retrospectively analyzed,and the risk factors of NAFLD complicated with hypertension disease were analyzed.Results The levels of age(t =1.69,P <0.05),body mass index(BMI)(t =0.36,P <0.05),waist circumference(t =0.64,P <0.05), total cholesterol(TC)(t =2.31,P <0.05),total bilirubin(TBS)(t =6.83,P <0.05),serum creatinine(Scr)(t =2. 20,P <0.05)in NAFLD complicated with hypertension group were higher than those in NAFLD group,and the differ-ences were statistically significant(P <0.01 or P <0.05).The logistic regression analysis showed that TC(OR =4.2)was the independent influencing factor of NAFLD with hypertension.Conclusion NAFLD is closely associated with hypertension,NAFLD can be incorporated into chronic disease management system with high blood pressure in order to improve the value of the disease in the elderly,and it is conducive to the further study of NAFLD and the management of other chronic disease.

During 1920-30s,under the push of Kuomintang,Communist Party and social personage,the Chinese village launched a cooperation movement. Although they failed to renew rural areas in China,the farmer autonomy spirit, policy practicality,the educational principles,and the spirit of evidence-based demonstration research embodied in the movement still have an enlightening significance to the construction of the new rural cooperative healthcare system and construction of new-type villages.

OBJECTIVE:To study the characteristics of doctors'behavior in clinical pharmaceutical service in hospi?tal.METHODS:Using statistical method,the doctors at their posts in nationwide scope were sampled and investigated by question-naires.RESULTS&CONCLUSION:Hospital doctors have a relatively vague cognizance of clinical pharmacists'work and they are cautious about clinical pharmaceutical service.They admit that they have requirements of clinical pharma?ceutical service,but at the same time they doubt of the pharmacists'capability,and they are just willing to accept the service selectively.

OBJECTIVE:To study the behavioral characteristics of nurses(or chief nurses)in the clinical pharmacy ser?vices.METHODS:Statistical method like questionnaires was used to investigate the clinical nurses(or chief nurses)nationwide at random.RESULTS&CONCLUSION:The nurses(or chief nurses)had positive attitudes towards clinical pharmacy services and thought highly of the clinical pharmacists'work both inwardly and outwardly.There is a great need for the knowledge of the pharmacy administration method in the clinical pharmacy services.

Social capital is an invisible capital form that promotes the efficient allocation and utilization of resources.It plays an active role in the prevention and control of chronic diseases.The purpose of this study is to investigate the effect of social capital on the three levels prevention of stroke by means of document retrieval.Social capital is associated with both morbidity and mortality of stroke.Social participation and social support at a high level can promote the rehabilitation of stroke patients,and have a beneficial effect on improving the quality of life and the ability of daily life.Social capital is correlated with stroke related behavioral factors,such as smoking,drinking,obesity,diet and physical activity.People with high social capital stock are more likely to choose healthy behavior patterns,thus reducing the risk of stroke.We should take full account of the social capital factors,and make more comprehensive and effective completion of the three levels of stroke prevention.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; therapy ; Humans ; Medicine, Chinese Traditional ; Phytotherapy

OBJECTIVE To investigate the occurrence of injuries by sharp instrument among new medical staff and their preventive consciousness and measures.METHODS Through questionaires,one hundred and fifty four interns who graduated from 2004 to 2006 were surveyed retrospectively.RESULTS Of the new interns,126(81.8%)persons were injured 585 times by sharp instrument,87.8% of whom were injured twice.During the internship,83 persons had passed sharp instrument injury prevention training,and earned priorities in its prevention.In the group of 83 persons trained,59 persons(71.1%) were injured;in another group of 71 persons untrained,67 persons(94.4%) were injured,there was significant difference at the rate of injuries between two groups.Opening ampules,and manipulating needles of syringes or infusion devices were the three major causes due which sharp injuries happened,were accounted for 35%,27% and 22%.CONCLUSIONS New medical staff have high rate of the sharp instrument injuries during internship,the occurrences of injuries are mostly due to the inadequacy in consciousness,the inpreficiency in operating,the high rate of with sharp instrument.Therefore,to reduce the sharp instrument injuries,developing good operating habit;performing operating procedure conscientiously;using medical equipment which can prevent injuries are the effective measures.

MicroRNAs(miRNAs),small noncoding RNAs,are essential for posttranscriptional gene regulation and have important roles in a wide range of biological processes,including development,growth and differentiation. Thousands of miRNAs have been identified in animals,plants and microoaganisms. miRNAs regulate their target genes by mRNA degradation or translation suppression. About 30 % of genes in an organism are subject to miRNA regulation. miRNA expression and function are regulated by transcriptional factors,epigenetics,single nucleotide polymorphisms,RNA editing and so on. Additionally,the success in knocking out a specific mouse miRNA gene has provided a valuable model for studying miRNA function.