OBJECTIVE:To facilitate the construction of Chinese pharmaceutical profession associations. METHODS: We analyzed the current situation and problems existing in Chinese pharmaceutical profession association as well as the developmental experience of foreign pharmaceutical associations then put forward suggestions for the development of pharmaceutical profession associations in China. RESULTS & CONCLUSIONS: The sound development of pharmaceutical profession associations calls for the cooperated efforts of government, profession association and pharmaceutical enterprises, meanwhile its function as bridge and tie between pharmaceutical enterprises and government should be brought into full play.

OBJECTIVE:To provide references for Chinese drug distribution reform.METHODS:The drug distribution model in USA was briefly introduced and compared with that in China.The difficulties and orientations in Chinese drug distribution reform were put forward.RESULTS &CONCLUSIONS:Drug distribution reform should be carried out cautiously.Our government should deal well with the relationships between different interested parties and set up a reimbursement mechanism in medical institutions in order to facilitate the reform.

OBJECTIVE:To further perfect the discipline theory of pharmaceutical administration in China.METHODS:The processes and methods of the discipline theory construction of pharmaceutical administration was studied by deductive theory and‘taking root’theory.RESULTS&CONCLUSION:The pharmaceutical administration theory is characterized by diverse and empirical,to make it improved,more research work needs to be done.

Objective:To analyze and evaluate the effect after the PIVAS workflow optimization in our hospital. Methods: One-for-one grouping preparation was carried out by pharmacists and nurses. The checking of medicines, solvents and empty ampoules be-fore and after the preparation was performed by pharmacists, and the preparation of infusions was operated by nurses according to the operation specification. The preparation workload, error number in each link and damage of ampoules and finished goods before the op-timization and in 5 months after the optimization were compared. Results:The working efficiency was obviously improved with less time of about 0. 5 h for the same workload, the error rate was decreased by 40%, and the ampoule damage was reduced by 60% before and during the preparation. Conclusion:The PIVAS workflow optimization improves the working efficiency and management level.

MicroRNA-451 (miR-451) is significantly lowly expressed in glioma,gastric cancer,colorectal cancer,liver cancer and other tumor tissues.Upregulation of miR-451 can significantly inhibit tumor cell proliferation,invasion and metastasis as well as increasing tumor cell apoptosis and improving radiotherapy and chemotherapy sensitivity and other biological effects.

Objective To explore the causes of the misdiagnosis of spontaneous rupture of spleen.Methods 8 cases of spontaneous rupture of spleen during 1986～1998 were reviewed retrospectively.Results 5 cases were misdiagnosed, with the misdiagnosing rate of 62.5%.Conclusion For unknown upper bellyache accompanied with unexplainable loss of blood and with no history of trauma,the patients should be examined by B ultrasound or abdominal puncture should be peformed.If there is pathological process of liver and spleen such as schistosoma and hepatitis or the excessive functioning of spleen,the more attention should be paid to the occurrence of spontaneous rupture of spleen.Furthermore,the increase of the belly pressure caused by satiation or hard labour helps to diagnose such case.

Objective: To evaluate the feasibility of performing muscle-sparing thoracotomy and intercostal sutures in the treatment of upper and/or middle thoracic esophageal cancer for the purpose of tumor control and postoperative quality of life improvement.Methods: Seven patients with esophageal cancer were treated with vertical muscle-sparing thoracotomy and Mckeown esophagectomy.Detailed clinic data were summarized and analyzed with patient follow-up information.Results: Of the 7 patients,five were still alive with a 71.4% five-year survival rate.There were no deaths resulting from the operation in this group.The mean length of thoracic incision was 11 cm.The range of hospital stays was 14 to 25 days,with a mean length of 18 days.No patients complained of impaired shoulder action,and the incision pain was hardly perceived without external stimulation 1 month after operation.Conclusion: Performing the muscle-sparing thoracotomy in the treatment of early-stage esophageal cancer located in the upper and /or middle thoracic segment yields a satisfactory long-term survival rate with an improved life quality in terms of incision pain relief and shoulder function.

Objective To investigate the methods of preoperation diagnosis and treatment of primary gastric lymphoma of mucosa-associated lymphoid tissue(MALT).Methods To analyze retrospectively the diagnosis and treatment of 54 cases of MALT lymphoma diagnosed surgically and pathologically.Results The most common symptoms were stomachache or discomfort.Of the patients with MALT lymphoma,85.2%(46/54)cases were diagnosed by preoperation gastroscopy with biopsy.Helicobacter pylori was found in 48 cases(88.9%).The overall resection rate for MALT lymphoma was 87%(47/54).The 5-year and 10-year survival were 77.1% and 72.9%,respectively.Conclusions It is obvious that MALT lymphoma is associated with Helicobacter pylori.Since no specific symptoms in gastric MALT lymphoma,the preoperative diagnosis is relied upon the application of gastrointestinal image,gastroscopy and repeated biopsy.The use of curative resection with the post-operative chemotherapy and/or radiotherapy to treat MALT lymphoma is reasonable.

There are multiple sophisticated approaches that can be used in estimations on health effects resulting from environmental pollution. By comparison, human capital approach and averted expenditure approach are not suitable to be the first choice because of the insufficient capability of capturing all aspects of health effects. Date availability and estimation extrapolation limit the application of hedonic wage approach and hedonic price approach. It has been accepted universally for the flexible technique provided by contingent valuation approach that any health effects can be separately evaluated depending on researchers' purposes. Based on the powerful macroeconomic theory, general equilibrium theory, the CGE model is powerful to simulate the mechanism of interaction between multi-sectors with a national economic system so as to objectively reflect the health impacts on national economy due to environmental pollution.

OBJECTIVE:To put forward strategies to evolve the current drug bidding system.METHODS:The objective and efficacy of the drug bidding system was analyzed;and the reasons for the poor efficacy of the system were analyzed using the information asymmetry theory in economics,and the system was compared with its US counterpart.RESULTS & CONCLUSIONS:The drug bidding system in China should adopt such model in which the payers are chosen as agency and charge from the entrusting party.It is a systematic project to standardize drug circulation channels,reduce drug price and reduce the burden of patient,which can't be tackled by drug bidding system only.