The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

Pancreatic cancer is characterized by high malignancy, low early diagnosis rates, and poor prognosis. Approximately 15%-20% of patients at initial diagnosis have resectable pancreatic cancer, 20%-30% have borderline resectable pancreatic cancer, and over 50% are present with unresectable. Surgical resection remains the only potentially curative treatment option available, but the unique anatomical position of the pancreatic head necessitates complex gastrointestinal reconstruction after resection, which may lead to severe complications such as grade B/C pancreatic fistulas and bleeding. Comprehensive preoperative preparation and individualized postoperative management are crucial to reducing perioperative complications, enhancing patient quality of life, and expediting the initiation of adjuvant therapy. This article reviews perioperative integrated management strategies for patients with pancreatic cancer, drawing on literature and our center's experience, including nutritional therapy, psychological support, preoperative jaundice reduction, neoadjuvant treatment, the prevention and management of pancreatic fistulas and postoperative bleeding, with the aim of improving clinical outcomes and overall survival rates.

The construction of National Regional Centers is a significant strategic deployment to promote the expansion of high-quality medical resources and a balanced regional layout.It introduces the performance of Peking University First Hospital in promoting the construction of National Regional Centre for women and children's hospital with the work mode of"geographical homogenization construction",summarizes effectiveness.It is believed that government support is the foundation,output hospital sinking is the key,and input hospital participation is the guarantee.

The special suppressive tumor immune microenvironment is a significant factor in the high postoperative recurrence rate and insensitivity to immunotherapy in pancreatic cancer. Tertiary lymphoid structures (TLSs) are pathologic ectopic lymphoid tissues composed of various immune cells, playing a crucial role in regulating adaptive anti-tumor immune responses. The presence of TLSs in pancreatic cancer tissues signifies better prognosis and immune therapy response. Examining the quantity, location, maturity, and cellular components of TLSs in pancreatic cancer specimens helps predict prognosis and screen potential beneficiaries of immunotherapy. Exploring key factors inducing TLSs formation and elucidating the anti-tumor immune mechanisms of TLSs may provide a new theoretical basis for enhancing the efficacy of pancreatic cancer immunotherapy. The authors summarize the clinical status and hot topics of TLSs in pancreatic cancer applications, and look forward to the research directions of TLSs in the field of pancreatic cancer.