1.Tumor dormancy of hereditary medullary thyroid carcinoma and RET gene mutations.
Yang YÜ ; Ming GAO ; Fei ZHANG
Chinese Journal of Oncology 2008;30(7):532-533
Base Sequence
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Carcinoma, Medullary
;
genetics
;
surgery
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Codon
;
genetics
;
Exons
;
genetics
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Female
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Humans
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Middle Aged
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Mutation
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Proto-Oncogene Proteins c-ret
;
genetics
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Thyroid Neoplasms
;
genetics
;
surgery
;
Thyroidectomy
2.Relationship between expression of Bax and Bcl-2 proteins and apoptosis in radiation compound wound healing of rats.
Yü-fang CUI ; Guo-wei XIA ; Xiao-bing FU ; Hong YANG ; Rui-yun PENG ; Ying ZHANG ; Qing-yang GU ; Ya-bing GAO ; Xue-mei CUI ; Wen-hua HU
Chinese Journal of Traumatology 2003;6(3):135-138
OBJECTIVETo study the relationship between the expression of Bax, Bcl-2 proteins, and apoptosis in radiation compound wound healing of rats.
METHODSApoptosis, Bax and Bcl-2 proteins were estimated by in situ terminal labeling (TUNEL) and immunohistochemical methods.
RESULTS(1) Changes of the apoptosis in wound healing showed three typical characteristics: early occurrence, high frequency and delayed disappearance after radiation to rats when compared with those of simple wound group, which might be an important reason for radiation-induced delayed wound healing. (2) The expression of Bax protein increased evidently with the increment of apoptosis and showed a good corresponding relationship with the apoptotic frequency in the process of wound healing. While the expression of Bcl-2 protein decreased obviously as the apoptosis reached a maximum and showed increasing tendency up to normal level when the apoptosis decreased distinctively.
CONCLUSIONSBax and Bcl-2 proteins play an important role in the apoptotic regulation of radiation compound wound healing in rats.
Animals ; Apoptosis ; radiation effects ; Female ; Gamma Rays ; Immunohistochemistry ; Proto-Oncogene Proteins ; biosynthesis ; genetics ; Proto-Oncogene Proteins c-bcl-2 ; biosynthesis ; genetics ; Rats ; Rats, Wistar ; Skin ; pathology ; radiation effects ; Wound Healing ; genetics ; radiation effects ; bcl-2-Associated X Protein