No abstract available.
Child* ; Humans

No abstract available.
Diagnosis*

Alzheimer's disease(AD) is one of the most common causes of mental deterioration in elderly individuals, accounting for around 45~60% of the overall cases of dementia over 65 years of age. Although there is presently no "cure" for AD, a large number of potential therapeutic interventions have emerged to correct cholinergic dysfunctions. Currently, cholinergic therapy, particularly cholinesterase inhibition, represents the most realistic approach to the symptomatic treatment of AD. Modest efficacy for mild to moderate AD has been shown in well-designed clinical trials for tacrine, donepezil, rivastigmine, and galantimine. Among other treatment options, estrogen replacement therapy in postmenopausal women is under active investigation, but recent studies showed somewhat disappointing results. Epidemiological and clinical data suggest that nonsteroidal anti-inflammatory drugs are beneficial in the treatment and prevention of AD. But prednisone and COX-2 inhibitor, celecoxib showed no clinical benefit in recent studies. Alpha-tocopherol and gingko biloba showed some beneficial effect in delaying the progression of AD and enhancing cognitive functions. Immunization with beta amyloid peptide was considered to be the only method to prevent and halt disease progression in patients with AD. Recently, phase II clinical trial using synthetic beta amyloid peptide (AN-1792) was discontinued because some patients showed neuro-inflammation which may be caused by autoimmune responses.
Aged ; alpha-Tocopherol ; Alzheimer Disease* ; Amyloid ; Autoimmunity ; Celecoxib ; Cholinesterases ; Cognition ; Dementia ; Disease Progression ; Estrogen Replacement Therapy ; Female ; Ginkgo biloba ; Humans ; Immunization ; Methods ; Prednisone ; Rivastigmine ; Tacrine

No abstract available.
Hypertension, Renovascular*

No abstract available.
Child* ; Humans ; Male*

No abstract available.
Diabetes Mellitus* ; Insulin*

No abstract available.
Animals ; Growth Hormone* ; Hypothyroidism* ; Rats*

No abstract available.

An epidemiological study is to observe and analyse 100 cases of lung cancer in Korean, which had been diagnosed actually at the general hospitals in Korea from 1970 through 1974, to discover the tendency of the lung cancer by sex, age, occupation, duration of clinical symptoms before diagnosis, site of cancer in lung, size of cancer, occurrence, treatment, prognosis, smoking and pathological findings as follows. 1. Males were affected 5.7 times more than females, the peak incidence of lung cancer were 50 years old age group. 2. The occupations of the cases were commerce, agriculture, industry, laborers and teachers, etc. in thht order. 3. The average duration symptoms from onset to diagnosis were 5.5 months. 4. The cancers were affected more right side than left side of the lungs, Particularly the most of them were affected in the upper lobes of the lungs. 5. The average diameter of the tumors was 5.5crX6.5cm, However the largest of them was 10cm X 13cm. 6. The most cases of the lung cancers were occurred primarily. 7. Out of the 100 cases, 58 cases had no treatment, 23 cases had palliative-symptomatic treatment, of cases by special chemo-therapy, 7 cases by surgery, and 5 cases by cobalt 60 or X-gay. 8. In the view point of prognosis, the most cases of the lung cancers died within one year atfer diagnosis. 9. The smoking was one of the causative factor of lung cancer, but there was no significant diferentiation by means of the amount of smoking. 10. The most cases of the lung cancers diangosed histo-pathologically, were epidermoid(squamous) type.
Agriculture ; Cobalt ; Commerce ; Diagnosis ; Epidemiologic Studies* ; Female ; Hospitals, General ; Humans ; Incidence ; Korea ; Lung Neoplasms* ; Lung* ; Male ; Middle Aged ; Occupations ; Prognosis ; Smoke ; Smoking

BACKGROUND: The heart rate adjusted ST segment criteria(Delta ST/HR index and rate-recovery loop or R-R loop) compared to standard ST segment criteria may improve the ability of the exercise electrocardiogram for the prediction of severe coronary artery disease and future cardiac events in patients with chronic angina pectoris, but the predictive value of these criteria for predicting these issues has not been studied in patients with acute myocardial infarction. METHODS: 64 patients with first uncomplicated myocardial infarction were studied. All patients performed predischarge(mean 8+/-4 days) symptom-limited exercise test and coronary angiography(mean 11+/-15 days). During the follow-up period(mean 449+/-273 days), the occurrence of the major cardiac events(death, reinfarction, coronary artery bypass surgery) and minor cardiac event(angina, heart failure) were recorded, and then univariate and multivariate analysis of several clinical and exercise variables known to be as prognostic markers were performed. RESULTS: The results are as follows : 1) The sensitivities of Delta ST/HR index and R-R loop(92%, 83% respectively) for predicting multivessel disease showed no significant difference compared to that of standard ST segment criteria(83%). 2) Major cardiac events occurred in 12(20%) of 64 patients and only single independent predictive factor for its prediction was multivessel coronary artery disease(p=0.0001), whereas total cardiac event occurred in 32(50%), multivessel disease(p=0.003), and maximal workload <5mets(p=0.038). 3) For the prediction of total cardiac event, DeltaST/HR index and R-R loop(all 97%) were significantly more sensitive(p<0.05) than standard ST segment criteria(78%), and there was a tendency to increase in specificity in R-R loop(84%) compared to DeltaST/HR index(59%) or standard ST segment criteria(66%). 4) The negative predictive value of all negative test of three ST segment criteria for predicting total cardiac event was 100%. CONCLUSION: Although the heart rate-adjusted ST segment criteria have no advantage over standand ST segment criteria for the prediction of severe coronary artery disease, they can be more useful prognostic markers by enhancing the accuracy of the predischarge exercise electrocardiogram for the prediction of subsequent cardiac events after a first acute myocardial infarction.
Angina Pectoris ; Coronary Artery Bypass ; Coronary Artery Disease ; Coronary Vessels ; Electrocardiography ; Exercise Test* ; Follow-Up Studies ; Heart ; Heart Rate ; Humans ; Multivariate Analysis ; Myocardial Infarction* ; Prognosis ; Sensitivity and Specificity