OBJECTIVE: To explore the clinical efficacy of irbesartan, enteric-coated aspirin combined with tetramethylpyrazine in the treatment of diabetic nephropathy. METHODS: 75 patients with diabetic nephropathy were randomly divided into treatment group(n=40) and control group(n=35). Both groups were administered with 150 mg irbesartan(p.o.) and 100 mg enteric-coated aspirin (p.o.) once a day. Treatment group were additionally treated with 0.9% normal saline containing 200 mg tetramethylpyrazine once a day (i.v.gtt). During 28 days of treatment, treatment group was compared with control group in respect of 24-h urine protein, blood lipids, blood rheology. RESULTS: After treatment, hemorheological indexes (?b, EAI), renal function indexes(Scr、BUN、24-h urine protein) , Serum lipids(TG, TC) were decreased significantly(P

0.05).Micro-suture materials has produced milder tissue reaction than silk during all experimental periods(P

Objective: To study the effect of chronic intermittent hypoxia on cognitive functions in Sprague-Dawley rats and the expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus.Methods: Experiments were performed on 16 three-month-old male Sprague-Dawley rats,They were randomly assigned to two experimental groups(n=8/group): chronic intermittent hypoxia group(CIH),and unhandled control group(UC).Rats in UC group were raised normally,and those in CIH group suffered 7H intermittent hypoxia everyday,The duration of experiment was 8 weeks.The learning and memory ability of rats in each group were assessed with the Morris water maze test at the end of the experiments.The expression of Insulin-like Growth Factor-1 in CA1 region of hippocampus was investigated by immunohistochemistry staining and image analysis.Results: ①Morris water maze test learning scores(place navigation): After 5 days training,the escape latency in CIH rats was significantly longer than that in UC rats(P

Objective To study the formulation and preparation of Qinglan Jingao tabales.Methods The orthogonal design was taken for the optimization,the contents were selected by granule,rigidity,crack and disintegration.Results The optimum dropping condition was as follow:the rate of Qinglan extraction to starch and dextrin was 25∶4∶1(kg),the added amount of 95%alcohol was 0.25 times(kg),mix 8 minutes by the wet granule compression technique.Conclusion The optimum extracting procedure is scientific,reasonable and stable.

Objective To compare the clinical effect of reconstructing the anterior and posterior cruciate ligaments of knee joint with al-lografttendon and autogenous tendon transplantation. Methods 130 patients with anterior and posterior cruciate ligaments of knee fractured were randomly divided into two groups:the observation group were given allogeneic tendon transplantation while the control group were autol-ogous tendon transplantation. Observed the clinical efficacy of the two groups. Results The operation time of the observation group was ob-viously less than control group(P<0. 05); there was no statistically significant difference in the IKDC of the observation group compared with the control group (P>0. 05);the Lysholm and Tengner score of the two groups were significantly higher compared with the preoperative scores with a statistically significant difference (P<0. 05), but there was no statistically significant difference between Lysholm scoreand Tengner score of the two groups after operation(P>0. 05). Conclusion Allogeneic tendon transplantation has similar curative effect with autologous tendon transplantation, both of them are good transplantation material for anterior and posterior cruciate ligaments reconstruction.

Clinical skills training is a key factor for improvement of the quality of clinical teaching.Developing highly specific clinical skills training specification is an important step to improve the quality of gynecologic oncology clinical teaching.Based on its importance,a'four steps training strategy,known groups-building specification-train thinking-make a request is developed and used by Dept.of Obsterics and Gynecology,the 3rd Affiliated Hospital,Kunming Medical University.It guides students to achieve the basic theory,basic knowledge and basic skills through a comprehensive way,and it also encourages students with highly learning initiative of gynecologic oncology clinical skills.On the other side,in the clinical skills training will lead teachers to develop their thinking and enhance the enthusiasm of teaching.This method provides a new sight for gynecologic oncology clinical skills training in a new manner.

Objective To observe the influence of modified Sijunzi Decoction on the decrease of immune function of exercise-induced exhaustion rats. Methods Thirty SD rats were given adaptive training, and then 6 dead or non-adaptive rats were dropped out. The remaining 24 SD rats were randomly divided into normal group ( N= 8) , model group ( N = 8) , and modified Sijunzi Decoction group ( MSD group, N = 8) . Normal group did not receive any medication and took diet freely. The rats of model group and MSD group were orally given distilled water or modified Sijunzi Decoction 8 g per day respectively after the modeling by exercise-induced exhaustion. After 61 days, the serum was taken from the three groups, and immunoglobulin lgA, lgG, lgM, and complement C3,C4 were detected. Results The contents of immunoglobulins IgA, IgG, IgM and complements C3, C4 in MSD group were higher than those in the model group ( P<0.01) . Conclusion The decrease of immunity occurs in the process of exercise stress, but can be delayed by modified Sijunzi Decoction..

Objective To investigate the effect of preoperative visit on reducing anxiety of patients undergoing carotid endarterectomy. Methods 120 cases of patients with carotid endarterectomy were randomly divided into the observation group and the control group with 60 patients in each group, in the control group, before surgery, the nurse of ward gave routine preoperative nursing care and health education.In the observation group, in addition to routine preoperative care and health education, there were preoperative visits by intensive care unit nurses, the anxiety level was compared 1 day before surgery and 2 to 3 days after surgery. Besides, the cooperation degree of patients was also compared. Results There was no significant difference in anxiety levels in the observation group, but there was significant difference in anxiety levels in the control group, there was significant difference in patients coordination degree between two groups. Conclusions Preoperative visits by intensive care unit nurses can reduce the anxiety level of patients, shorten hospital stay and promote early recovery of patients.

Antipsychotic Agents ; therapeutic use ; Brain ; physiopathology ; Cognition Disorders ; genetics ; Gene-Environment Interaction ; Genetic Variation ; genetics ; Humans ; Schizophrenia ; genetics ; physiopathology ; Schizophrenic Psychology ; Social Behavior ; Thinking ; physiology

Objective : To analyze the clinical characteristics of patients with adenomyosis (AM) and endometrial cancer (EC) and their role in preoperative diagnosis. Methods : A total of 142 patients with AM complicated with EC or endometrial atypical hyperplasia (EAH) and AM with abnormal uterine bleeding ( AUB) during the same period were collected from this hospital. They were divided into AM with EC or EAH group (71 cases) and control group (71 cases) according to whether they were complicated with EC or EAH. The clinical data of the patients were retrospectively analyzed , and the clinical characteristics and treatment strategies of the patients with adenomyosis complicated with endometrial cancer were discussed. Results : Univariate analysis showed that age , increased proportion of CA125 and CA125 , uterine volume , proportion of hypertension and abnormal endometrial ultrasonography in patients with AM with EC or EAH were significantly higher than those in the control group , and the proportion of dysmenorrhea was significantly lower than that in the control group , and the difference was statistically significant (P < 0. 05) . Multivariate Logistic regression analysis showed that endometrial thickening , endometrial echogenicity , and endometrial thickening combined with echogenicity were independent risk factors for AM with EC or EAH. Conclusion In clinical practice , the patients with AM with endometrial thickening or uneven echo - echo of ultrasound should be treated by hysteroscopy and curettage before further operation plan is formulated , so as to achieve the purpose of early diagnosis and treatment of EC.