One of the important therapeutic measures in the acute stage of cerebral hemorrhage is to treat cerebral edema and lower intracranial pressure. Mannitol, an osmotic dehydrant, is most widely used in clinical practice. Its major effects include the reduction of intracranial pressure and cerebral edema and prevention of cerebral herniation. Besides, mannitol scavenges oxygen free radicals and protects brain cells. So it has extremely important significance in reducing the mortality of intracerebral hemorrhage.

Objective: The paper inquires into a new external temporary cardiac pacing method. Method: The research uses a microcomputer-based multi-functional external temporary cardiac-pacing device made by the authors for sending pacing signals. The pacing mode and pacing rate of the device can be adjustable. The pacing pulse width and pacing current of the device can also be adjustable. It inserts a syringe necdle-like negative pacing pole into the chest muscle in the prior-cardiac area of a male adult mongrel dog; it pastes a positive pacing pole on the back area near heart of the dog. It takes intravenous injection isoptin 5mg into the male mongrel dog. After 5 minutes, the heartbeat of the dog suddenly stops; it does pacing experiment for the dog at this time and observes the results of the pacing experiment. Results: After temporary cardiac pacing, the heartbeat of the dog returns, pacing ECG of the dog appears, the pacing for the dog is active. Conclusions: It is a new and benefit external temporary cardiac pacing method.

Objective To explore the feasibility of two-port laparoscopic drainage in the treatment of liver abscess. Methods A total of 18 patients with bacterial hepatic abscess underwent twoport laparoscopic drainage.Two incisions were made at the superior border of the umbilicus and 4～5 cm below the right costal margin near the anterior axillary line,respectively.The abscess was cut through in "┼" or "╫" shape.The pus cavity was debrided bluntly,and a double-lumen drainage tube was placed.Results The laparoscopic drainage was performed successfully in all the 18 patients.The operative duration was 30～75 min(mean,45 min).A bile leakage for 80～100 ml per day occurred in 1 patient.The drainage tube was removed on the 12th postoperative day and the patient was discharged from hospital on the 14th postoperative day.Of the 18 patients,the hospital stay after operation was 7～14 d(mean,8.5 d).All the patients were followed for 5～12 months(mean,9 months) and no residual abscess or recurrence was found. Conclusions Two-port laparoscopic drainage for liver abscess is an ideal approach with advantages of simple manipulation,slight contamination inside abdominal cavity,little trauma,low complication rates,and rapid recovery.

Objective To investigate the types of commonly used anti-hypertensive drugs and hypoglycemic drugs and treatment schemes to provide a basis for rationally treating hypertension complicating type 2 diabetes mellitus(T2DM).Methods The medication situation in 191 patients with hypertension complicating T2DM in our hospital were analyzed and investigated.The use of anti-hypertensive drugs and hypoglycemic drugs and treatment scheme were statistically analyzed.Results In 191 patients with hypertension complicating T2DM,the single drug use in the anti-hypertensive scheme accounted for 9.42 ％,two-drug combined use accounted for 64.91％,three-drug combined use for 17.8 ％ and four-drug combined use for 7.85 ％.The medication of ARB+CCB had the highest use frequency;the anti-hypertensive total effective rate was 96.86 ％.In the hypoglycemic schemes,the insulin use accounted for 30.37％,and the use frequency of metformin+ gliclazide was highest,the hypoglycemic total effective rate was 98.43％.Conclusion The medication for the patients suffering from hypertension complicating T2DM is relatively reasonable,and worth of being popularized and applied in clinical practice.

Bacterial translocation is a major contributor to sepsis and multisystem organ failure.This paper reviews the studies in recent years.We will briefly introduce the advance in bacterial translocation,and expound its pathogenesis,prognosis,diagnosis,therapy,as well as significance and prospects.

Objective To investigate the prevalence and the distribution in population of cervical intraepithelial neoplasia (CIN) and cervical cancer among rural women in Qianjiang district of Chongqing city .Methods From April 2010 to April 2012 ,25 128 married rural women in Qianjiang district were performed screening and detection .The individuals with the positive results were performed the colposcopy and cervical biopsy .Results 112 cases were found with the positive results of the pathological examina-tion ,including 58 cases of CINⅠ ,26 cases of CINⅡ ,19 cases of CINⅢ and carcinoma in situ and 9 cases of invasive carcinoma .The incidence rate of CIN and cervical cancer in Tujia nationality women was significantly higher than that in Han nationality women and Miao nationality women .Conclusion The cervical cancer screening is an important way to find early pathological lesions of cer-vical cancer and prevent cervical cancer ,and is the necessary measure to reduce the incidence rate of cervical cancer in rural women .

Objective To understand antimicrobial resistance and therapeutic efficacy of imipenem/cilastatin and meropenem for treatment of multidrug-resistant Pseudomonas aeruginosa (MDRPA)from patients with mechanical ventilation.Methods From January 2010 to December 2015,78 patients with mechanical ventilation and isolated MDRPA from sputum cultures were selected and divided into imipenem/cilastatin (n=44)and meropenem(n=34) treatment groups,basic condition,time of emergence of drug resistance,and therapeutic efficacy of antimicrobial agents between two groups were compared.Results The basic data of two groups were comparable,before treat-ment by imipenem/cilastatin and meropenem,resistance rates of Pseudomonas aeruginosa (P .aeruginosa )to quinolones,ceftazidime,piperacillin,and amikacin were not significantly different (all P >0.05).After patients received antimicrobial agents for 6 days,difference in antimicrobial resistance between imipenem /cilastatin and meropenem treatment groups were not significantly different (22.73% vs 8.82%,P >0.05).On the 8th,10th,and 12th day of treatment,resistance rates of imipenem treatment group were 40.91%,77.27%,and 97.73%, respectively,which were all higher than meropenem treatment group (17.65%,32.35%,44.12%,respectively,all P <0.05).After the treatment with different antimicrobial agents,the average time for the emergence of resistance in imipenem/cilastatin and meropenem treatment group were 9.0 days and 13.5 days respectively.Therapeutic efficacy between two groups was not significantly different (64.71% vs 74.19%,P =0.41).Conclusion Compared with meropenem,imipenem/cilastatin shows higher risk for the emergence of drug resistance during therapy of P . aeruginosa infection in patients with mechanical ventilation,there is no significant difference in therapeutic efficacy between two groups of patients after 7 days of treatment.

Objective To investigate the effect of non-hazard treatment of feces on control of intestinal infectious diseases and parasitosis. Methods During Nov, 2003-May, 2004, we selected 6 counties as observational points by the character of geographical position and the types of non-hazard treatment in Hunan province. The number of fecal coliform and the sedimentation rate of parasite ova were measured, the methods of questionnaire and retrospective study were used and the prevalance rate of intestinal infectious diseases, the incident rate of infectious diarrhea and infectious rate of parasite were analyzed. Results Among three types of non-hazard treatment, the eligibility rates of fecal coliform were 95.0%, 93.5%and 91.7% respectively,and the sedimentation rates of parasite ova were 90.0%, 90.3% and 87.5% respectively. Compared with the villages where the latrines had not been improved, the infectious rates of parasite decreased by 67.0%,the prevalance rate of intestinal infectious diseases decreased by 58.3%, and the incidence rates of infectious diarrhea decreased by 56.3% in villages where the latrines had been improved. Conclusion Non-hazard treatment of feces will play an important role in preventing of intestinal infectious diseases, infectious diarrhea and parasitosis.

Objective To investigate the relationship between the eosinophil (Eos) percentage and levels of eosinophil cationic protein (ECP) in induced sputum and the severity of late onset asthma(LOA) and differential diagnosis. Methods Fifty-four patients with LOA were selected. The percentage of eosinophil and levels of ECP were measured by Wrigbt′s stain and immuno-CAP system respectively. The lung function was also evaluated. The same indexes were measured in 25 elderly patients with chronic obstructive pulmonary disease (COPD) and 10 healthy elderly subjects as control. Results The percentage of Eos and levels of ECP in induced sputum in patients with LOA were significantly and negatively correlated with FEV_1/FVC (r=-0.68,-0.61, respectively, P

Objective To investigate the relationship between the number of eosinophil(Eos)and level of eosinophil cationic protein(ECP)in induced sputum and asthma severity and their value of differential diagnosis.Methods From July 2002 to June 2004,59 asthmatic patients were selected in the People Hospital of Wuhan University.The number of eosinophil and level of ECP were measured by Wrights' stain and Immuno-CAP System.The lung function was also evaluated.The same index was measured in 20 patients with COPD and 10 healthy subjects as control.Results The number of eosinophil in induced sputum in asthmatic patients negatively correlated with FEV_1%(r=-0.65,P