This study was aimed to investigate rules of medicine selections of four Meng-He (MH) medical schools. Based on frequency analysis and Apriori algorithm of association rules, data mining was conducted on 60 cases of four MH medical schools in the treatment of Chuan syndrome. The results showed that among 60 cases, Xing-Ren (XR), Ban-Xia (BX), Fu-Ling (FL), Hua-Ju-Hong (HJH), Su-Zi (SZ) and Bu-Gu-Zhi (BGZ) were the most com-monly used single medicine. The most commonly used medicine groups were SZ-HJH-FL, XR-Y i-Y i-Ren (YYR), XR-HJH, XR-SZ and so on. It was concluded that four MH medical schools in the treatment of Chuan syndrome mainly used antitussive and antiasthmatic Chinese medicines such as YR, BX, SZ, and complemented with BGZ for deficiency-nourishing, FL for dampness-removing, HJH for qi-regulating. It provided references for the clinical practice and treatment of Chuan syndrome.

Mammal multidrug and toxin extrusion proteins (MATEs) play an important role in the transport of organic cations in the body. MATEs mediate the final excretion step for multiple organic cation drug used clinically and important endogenous substances. This article reviews the discovery, type, gene coding and polymorphism, body distribution, classification of substrates and inhibitors and their research method of MATEs. The article also discusses the major research significance of MATEs with examples.

Objective To discuss the teaching method and effect of teaching-learn-do integration mode in the Basic Nursing Technology.Methods Students of two classes of grade 2010 and two classes of grade 2011 in our nursing college were randomly divided into the experimental group and the control group,they respectively adopted teaching-learn-do integration teaching mode and first-theory-after-practice traditional teaching method.The teaching effect of the two groups by theory and skills testing was compared.Results The experimental groups were better than the control groups in two grades in skill examination results.For the theoretical examination results,the experimental group of grade 2011 was better than the control group,while the two groups of grade 2010 were undifferentiated in theoretical examination.Conclusions Teaching-learn-do integration mode can not only improve students' operating skills,but also promote the theoretical learning,and improve the students' learning ability of independent innovation,suitable for practical and technical-strong course teaching in Basic Nursing Technology.

Objective To investigate the expression of glucose transporters(GLUTs)in placentas of pregnant women with abnormal glyeometabolism,and to explore its effect on glucose transport between mother and fetus and its relation with the birth weight.Methods Placentas of 41 pregnant women with abnormal glycometabolism(7 cases of DM,10 GDM A1,10 GIGT and 14 GDMA2)and 15 normal pregnant women as control were selected.The expression of GLUT1 and GLUT3was detected by immunohistochemistry.The birth weight was measured at delivery.Results GLUT1 was expressed in the syncytiotrophoblasts and cytotrophoblasts,whereas GLUT3 in some endothelial cells.The expressions of GLUT1 and GLUT3 were significantly different among the five groups(P＜0.01).Positive correlation was shown between the GLUT1 expression and the birth weight(rs=0.532,P＜0.01),but not in GLUT3 expression.Conclusions The expression of GLUT1 and GLUT3 in placentas of pregnancy with abnormal glycometabolism is enhanced,and GLUT1 may play a predominant role in the fetal glucose uptake.

Objective To explore the mechanism of the cumulative biological effect of acupoint laser radiation and investigate its analgesic effect by comparing the therapeutic effects of semiconductor laser radiation versus acupuncture at point Zusanli(ST36) in acute adjuvant arthritis rats and to provide the experiment-based theoretical foundation and basis for the course of treatment of acute arthritis pain by clinical use of semiconductor laser. Method A rat model of AA was made by subcutaneous injection of complete Freund's adjuvant into rat toe. Eighty rats were randomly allocated to eight groups:model, blank, three-day laser radiation, five-day laser radiation, seven-day laser radiation, three-day acupuncture, five-day acupuncture and seven-day acupuncture treatment groups, 10 rats each. The three laser groups separately received 650 nm semiconductor laser radiation. The three acupuncture groups separately received acupuncture with a filiform needle at point Zusanli(ST36) on the inflammation-affected side. Rat general condition, body weight, pain threshold value and ankle swelling degree were observed. Serum inflammatory factors IL-1、TNF-αand IFN-γcontents were measured by ELISA. Result There were statistically significant posttreatment differences in body weight, joint swelling degree and pain threshold between the laser treatment and acupuncture treatment groups of rats (P<0.05). There was a statistically significant post-treatment difference in joint swelling degree between three-day laser, five-day laser and seven-day laser treatment groups (P<0.05). Pain threshold was lowest at five days after treatment and increased somewhat at seven days after treatment in both the three-day laser and three-day acupuncture treatment groups. The IL-1 content tended to decrease on the whole and had a decreasing tendency at three and five days after treatment in both laser and acupuncture treatment groups. At seven days after treatment, it reached the lowest value in the laser treatment group but had a marked increasing tendency in the acupuncture treatment group. The IFN-γcontent had an increasing tendency at three and five days after treatment in both laser and acupuncture treatment groups. The IFN-γcontent tended to change gently in the laser treatment group from day five to seven after treatment. It tended to decrease from day five to seven after acupuncture treatment but was still higher than in the three-day acupuncture treatment group. The TNF-αcontent tended to decrease from day three to five after treatment in both laser and acupuncture treatment groups. From day five to seven after treatment, it tended to decrease gently in the laser treatment group but tended to increase slightly in the acupuncture treatment group. Conclusion Both semiconductor laser radiation and acupuncture at point Zusanli have an anti-inflammatory and analgesic effect and can relieve the general symptoms in AA rats, but semiconductor laser radiation is significantly superior to acupuncture treatment in eliminating inflammation and easing pain and produces a more timely and better therapeutic effect. After semiconductor laser radiation at acupoints, the related serum cytokines tended to increase or decrease slowly in AA rats after the turning point appeared during the treatment, which embodies the parabola feature of laser radiation treatment. It is showed that with an increase in laser radiation length, the biological effect of laser accumulates, suggesting that attention should be paid to the cumulative effect during laser treatment.

The traditional acupuncture and moxibustion therapies were adopted to treat 32cases of melanoderm's peripheral facial paralysis at remission stage, the effective rate was 93.8%, indicating that acupuncture and moxibustion therapies are effective for different races.

Objective To compare the difference between the short stature and normal boys testicular vol-ume,and to investigate the relationship between the short stature and testicular development.Methods Testicular testing for 70 cases of short stature by color doppler ultrasound from 4 to 12 years old,calculation of testicular volume average(MVT),references for the boy normal testicular volume provided by Peking union medical college hospital and the Beijing children's hospital,compared the above two groups.The short stature's height,weight,body mass index (BMI)for correlation analysis.Results The MVT of the short stature group were lower than normal,compared with the normal group differences statistically significant(P<0.05);The weight,BMI,MVT of idiopathic short stature had a tendency to decrease compared with complete lack of growth hormone deficiency from 10 to 12 years old;The short stature's height had low relativity with MVT(r=0.393,P=0.01 ),the weight had middle relativity with MVT(r=0.508, P<0.01),and the BMI had low relativity with MVT(r=0.352,P<0.01).Conclusion The testicular development of short stature is relatively slow,which should make early intervention for the gonad development of short stature.

Pulmonary asthenia is one of the chronic consumptive lung diseases because of the weakness of pulmonary lobe. It would be the outcome of many chronic lung diseases with poor prognosis. In recent years, preventing and treating pulmonary asthenia by traditional Chinese medicine (TCM) has been one of the research focuses and some fruits have been received. This paper summarized pulmonary asthenia from the aspects of etiology and pathogenesis, syndrome differentiation, TCM treatment so as to provide theoretical basis and proofs for treatment of pulmonary asthenia by TCM.

The paper analyzes the impact of MOOC on medical information resources construction,and proposes the response strategies for the information resources construction of medical library,including introducing Patron Driven Acquisitions (PDA) mode,strengthening digital resources construction efforts,developing medical MOOC course reference resources system and constructing medical library alliance.Meanwhile,it points out that the medical library is required to dig users'information demand further and solve the issue of MOOC copyright clearance.

Her-2 targeting therapy is an important part of the treatment for breast cancer with Her -2 overexpression.However,the therapeutic effectiveness is largely influenced by Her -2 resistance.Previous studies have confirmed that PI3K/AKT/mTOR signaling pathway is activated during the process of drug resistance to Her-2-targeting therapy.Therefore,investigating the PI3K/AKT/mTOR signaling pathway and drugs -targeted pathway are important for the treatment of breast cancer .