1.Expression of Cyclooxygenase - 2 in Intestinal Epithelial Cells in Response to Invasive Bacterial Infection and its Role of Epithelial Cell Apoptosis.
Jung Mogg KIM ; Shin Jae KANG ; Yang Ja CHO
Journal of the Korean Society for Microbiology 1999;34(5):479-489
Invasion of enteric bacteria, such as Salmonella and invasive E. coli, into intestinal epithelial cells induces proinflammatory gene responses and finally epithelial cell apoptosis. In this study, we asked whether invasive bacterial infection of human intestinal epithelial cells could upregulate cyclooxygenase-2 (COX-2) gene expression and whether increased COX-2 expression could influence intestinal epithelial cell apoptosis. Expression of COX-2 mRNA and prostaglandin (PG) E production were upregulated in HT-29 colon epithelial cells which were infected with S. dublin or invasive E. coli, as examined by quantitative RT-PCR and radioimmunoassay. Inhibition of COX-2 expression and PGE2 production using NS-398, a specific COX-2 inhibitor, showed a significant increase af epithelial cell apoptosis and caspase-3 activation in HT-29 cells infected with invasive bacteria. However, the addition of valerylsalicylate, a specific COX-1 inhibitor, did not change apoptosis in S. dublin-infected HT-29 cells. These results suggest that upregulated COX-2 expression and PGE2 production in response to invasive bacterial infection could contribute to host defense by inhibiting apoptosis of intestinal epithelial cells.
Apoptosis*
;
Bacteria
;
Bacterial Infections*
;
Caspase 3
;
Colon
;
Cyclooxygenase 2
;
Dinoprostone
;
Enterobacteriaceae
;
Epithelial Cells*
;
Gene Expression
;
HT29 Cells
;
Humans
;
Prostaglandin-Endoperoxide Synthases*
;
Radioimmunoassay
;
RNA, Messenger
;
Salmonella
2.The value of diagnostic laparoscopy in infertility.
Jae Ie YANG ; Yoo Suk JEONG ; Kyung Suk KANG ; Jae Kyun DOO ; Jong Duck KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1800-1807
No abstract available.
Infertility*
;
Laparoscopy*
3.Multiple epiphyseal dysplasia in one family.
Jae Do KANG ; Kwang Yul KIM ; Yang Hoon LEE ; Jae Bong PARK
The Journal of the Korean Orthopaedic Association 1991;26(1):304-309
No abstract available.
Humans
;
Osteochondrodysplasias*
4.A Case of Central Diabetes Insipidus Associated with Brachycephaly.
Woo Sik KANG ; Mee Kyung NAMGOONG ; Jae Seung YANG ; Baek Keun LIM ; Jong Soo KIM
Journal of the Korean Pediatric Society 1994;37(2):282-287
Brachycephaly is a kind of craniosynostosis. Because of premature closure of the coronal suture, the skull is shorter in the anteroposterior diameter but is widened with a high vault and the occiput and forehead are flattened. Diabetes insipidus had been reported in oxycephaly. We have experienced a case of central diabetes insipidus associated with brachycephaly. A brief review of related literatures is included in this report.
Craniosynostoses*
;
Diabetes Insipidus
;
Diabetes Insipidus, Neurogenic*
;
Forehead
;
Skull
;
Sutures
5.Treatment of Self-Injurious Behavior Through Behavior Therapy.
Bo In CHUNG ; Jong Soo KIM ; Jae Seung YANG ; Bong Sun KANG
Journal of the Korean Pediatric Society 1990;33(5):585-597
No abstract available.
Behavior Therapy*
;
Self-Injurious Behavior*
7.A Case of Adenoid Cystic Carcinoma of Bartholin's Gland.
Soon Gyu KIM ; Jin Woo SHIN ; Kwang Il KIM ; Yang Suk KIM ; Jae Seong KANG
Korean Journal of Gynecologic Oncology and Colposcopy 2000;11(2):209-212
Adenoid cystic carcinoma is a rare disease of which incidence is 10-15 % of bartholins gland carcinoma. The clinical presentation is characterized by a vulval mass that existed for a prolonged period to the onset of symptoms, usually infection, pain, and burningsensation Histologically, this tumor is characterized by cribriform pattern cell growing and perineural invasion. The obtaining of clear surgical margins is the most important aspect of treatment. Here we report a case of adenoid cystic carcinoma of the Bartholins gland with a brief review of literature.
Adenoids*
;
Carcinoma, Adenoid Cystic*
;
Incidence
;
Rare Diseases
8.Juvenile Granulosa Cell Tumor Arising in Undescended Testis: A case report.
So Ya PAIK ; Hae Youn KANG ; Jae Ho HAN ; Woo Ick YANG ; Seok Joo HAN
Korean Journal of Pathology 1999;33(5):376-379
Juvenile granulosa cell tumor is rare but one of the common congenital testicular neoplasms. Although histological features are typical of its ovarian counterpart, testicular juvenile granulosa cell tumor has a distinctly different clinical presentation. We report a case of juvenile granulosa cell tumor arising in the cryptochid testis of a 4-day-old newborn. A 6 5 5 cm sized multilocular cyst containing thick, mucinous fluid was found in the peritoneal cavity. The external surface of the cyst was smooth and the septae were relatively thin. The cyst consisted of numerous mucin-filled, cystic follicles lined by cells having vacuolated cytoplasm and round to oval dark nuclei without grooves. Cells resembling granulosa cells of an ovarian follicle were also observed in the intervening stroma forming irregular solid nests.
Cryptorchidism*
;
Cytoplasm
;
Female
;
Granulosa Cell Tumor*
;
Granulosa Cells*
;
Humans
;
Infant, Newborn
;
Male
;
Mucins
;
Ovarian Follicle
;
Peritoneal Cavity
;
Testicular Neoplasms
;
Testis
9.Transepidermal Elimination of Nevus Cells in Acral Lentiginous Nevus.
Hee Jeon YU ; Hong Yoon YANG ; Jae Yong BAHN ; Yun Suck KIM ; Seung Gu KANG
Korean Journal of Dermatology 1999;37(4):544-546
Pigmented lesions of palmar and plantar skin may cause diagnostic problems, because some features of benign lesions in these sites may raise the suspicion of melanoma if considered alone. Transepidermal elimlnation is a mechanism by which a substance is eliminated through the epidermis, and it is apt to be confused with a feature of melanoma that tumor cells are located at all layers of the epidermis. We report a case of transepidermal elimination of nevus cells in acral letiginous nevus which needs a differential dignosis of melanoma.
Epidermis
;
Melanoma
;
Nevus*
;
Skin
10.Histomorphometric study of machined titanium implants and calcium phosphate coated titanium implants.
The Journal of Korean Academy of Prosthodontics 2010;48(2):122-127
PURPOSE: The objective of this study was to investigate the effects of calcium phosphate coated titanium implant surface on bone response and implant stability at early stage of healing period of 3 weeks and later healing period of 6 weeks. MATERIAL AND METHODS: A total of 24 machined, screw-shaped implants (Dentium Co., Ltd., Seoul, Korea) which dimensions were 3.3 mm in diameter and 5.0 mm in length, were used in this research. All implants (n = 24), made of commercially pure (grade IV) titanium, were divided into 2 groups. Twelve implants (n = 12) were machined without any surface modification (control). The test implants (n = 12) were anodized and coated with thin film (150 nm) of calcium phosphate by electron-beam deposition. The implants were placed on the proximal surface of the rabbit tibiae. The bone to implant contact (BIC) ratios was evaluated after 3 and 6 weeks of implant insertion. RESULTS: The BIC percentage of calcium phosphate coated implants (70.8 +/- 18.9%) was significantly higher than that of machined implants (44.1 +/- 16.5%) 3 weeks after implant insertion (P = 0.0264). However, there was no significant difference between the groups after 6 weeks of healing (P > .05). CONCLUSION: The histomorphometric evaluation of implant surface revealed that: 1. After 3 weeks early healing period, bone to implant contact (BIC) percentage of calcium phosphate coated implants (70.8%) was much greater than that of surface untreated machined implants (44.1%) with P = 0.0264. 2. After 6 weeks healing period, however, BIC percentage of calcium phosphate coated implants group (79.0%) was similar to the machined only implant group (78.6%). There was no statistical difference between two groups (P = 0.8074). 3. We found the significant deference between the control group and experimental group during the early healing period of 3 weeks. But no statistical difference was found between two groups during the later of 6 weeks.
Calcium
;
Calcium Phosphates
;
Nitrogen Mustard Compounds
;
Tibia
;
Titanium