Far beyond simulating manual work with the computer system,hospital informatization entails a combination of information technology with hospital professional work.With a fully understanding of working procedure in hospital,an effective concordance based on informatization requirements is conducted so that the management and the collection of the information can follow the information flow,logistics,capital flow,working flow and organization flow.Management mode and organization framework of the hospital are also adjusted.Thus the hospital operation quality and efficiency are improved,and patients are offered seamless and continuous service,which really reflects the service theory: "Patient First".

Several models about epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)as first-line treatment in advanced NSCLC show different results.Combination with chemotherapy and EG-FR-TKIs did not indicate survival advantage.However,sequential chemotherapy in EGFR-TKIs and a single agent of EGFR-TKIs as first-line treatment of advanced NSCLC have made tremendous breakthrough,and give a new path in individual treatment of advanced NSCLC.Also EGFR mulatious in targeted therapy of advanced NSCLc has a sood predictive value of the etticacy.

AIM: To develop a method of determining notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 in Naomaitai Capsules(Radix et Rhizoma Ginseng Rubra,Radix et Rhizoma Notoginseng,Radix Angelicae Sinensis,etc.) by HPLC. METHODS: Notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 were determined by HPLC gradient elution method,Inertsil-ODS-3(5 ?m 4.6 mm?250 mm) column with Acetonitrile-water as the mobile phase was used for gradient elution.The flow rate was at 1.0 mL/min and the detective wavelength was at 203 nm.The column temperature was at 35 ℃. RESULTS: There was a good linear relationship at a range of 0.205-1.539 ?g for notoginsenoside R_1(r=0.999 6),the average recovery of 98.07%, and RSD of 0.51%(n=5),0.838-6.285 ?g for ginsenoside Rg_1(r=0.999 4),the average recovery of 97.66%,and RSD of(0.53%)(n=5),0.822-6.165 ?g for ginsenoside Rb_1(r=0.999 6),the average recovery of 98.19%,and RSD of 0.44%(n=5). CONCLUSION: The method is simple,reproducible and accurate with a strong specificify,and can be used for the quality control of Naomaitai Capsules.

AIM:To establish the quality standards for Qinghuo Tablets(Folium Isatidis,Radix et Rhizoma Rhei,Gypsum Fibrosum,etc.). METHODS:Folium Isatidis,Radix et Rhizoma Rhei,menthol in Qinghuo Tablets were identified by TLC.Indirubin and emodin were determined by HPLC.Agilent-ODS-3(5 ?m,4.6 mm?250 mm) column was used.The column temperature was at 25 ℃.Methanol-0.5% H_3PO_4(75∶25) was used as a mobile phase.The detection wavelength was at 289 nm.The flow rate was 1.0 mL/min. RESULTS:Folium Isatidis,Radix et Rhizoma Rhei,menthol could be detected by TLC.Indirubin showed a good linear relationship at the range of 0.071 4-0.714 ?g,r=0.999 7.The average recovery was 98.95%,and RSD was 0.57%.Emodin showed a good linear relationship at the range of 0.204-2.04 ?g,r=0.999 8.The average recovery was(99.01%),and RSD was 0.79%. CONCLUSION:The established method is rapid,accurate,reproducible with a strong specificify.

Objective To explore the relationship between heart rate variability(HRV)and serum high sensitivity C-reactive protein(hs-CRP)in type 2 diabetic aged patients.Methods Totally 30 aged patients with type 2 DM were enrolled in this study who were selected from the outpatients and inpatients of Department of Gerontology in the Third People's Hospital of Chongqing,and another 30 non-diabetic matched individuals were recruited as control.Their serum hs-CRP and 24 hour-electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis)from 24-hour Holter recording,including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5-minute mean RR intervals(SDANN)and square root of differences between adjacent NN intervals(rMSSD).Linear correlation analysis was carried out between their serum hs-CRP and HRV.Results HRV parameters of type 2 DM patients were significantly lower than those of non-diabetic patients,but hs-CRP values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive correlation with hs-CRP in type 2 diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum hs-CRP in aged patients with type 2 diabetes mellitus.

A backup data center near the primary data center using Storage Area Network is built with Fiber Channel technology. The specific disaster recovery software used to synchronize the two centers a highly reliable safety and expandable data storage management system with adequate redundancy is developed. Thus disaster recovery service can be provided for the hospital information system when disaster happens. To avoid the system risk and maintain the continuity of the hospital's activities the damaged part of the system will be taken over from.

Adult ; Citric Acid ; adverse effects ; Dust ; Humans ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Tooth Erosion ; chemically induced

BACKGROUND:We previously demonstrated that the acid fibroblast growth factor/fibrin gelatin implantation could greatly relieve denervated motor end-plate degeneration and myatrophy. OBJECTIVE:To study the effect of acid fibroblast growth factor/fibrin gelatin on preventing denervated motor end-plate degeneration using immunohistochemical method. DESIGN,TIME AND SETTING:A randomized controlled animal experiment was performed in Zhujiang Hospital,Southern Medical University from June to December 2006. MATERIALS:A total of 24 SD rats of clean grade were randomly divided into three groups:acid fibroblast growth factor/fibrin gelatin group,fibrin gelatin group,and blank control group,with 8 rats for each group. METHODS:Under the general anesthesia,right common peroneal nerves of rats in each group were cut off 1 cm away from the nerve muscle entry point. Acid fibroblast growth factor/fibrin gelatin group,perilemma was sutured and the compound was implanted into spatium intermusculare around denervated tibial muscle nerve region;fibrin gelatin group,perilemma was sutured and fibrin gelatin was implanted;perilemma was sutured without medication in the blank control group. MAIN OUTCOME MEASURES:After 6 weeks,neuromuscular junction of tibial muscle branch of common peroneal nerve and its peripheral muscles were separated. Acidic fibroblast growth factor receptor was detected by SP immunohistochemistry to observe expressive site of acidic fibroblast growth factor receptors,and count positive blood capillary. Gray scale of the acidic fibroblast growth factor receptor was detected using image analysis system. RESULTS:The acidic fibroblast growth factor receptor was mainly located in capillary vessel wall. High density of expressing area of acidic fibroblast growth factor receptor and intensive capillary vessels were in acid fibroblast growth factor/fibrin gelatin group. In contrast,low density of masculine expressing site of acidic fibroblast growth factor receptor in capillary vessel and rare capillary vessels were in fibrin gelatin group and blank control group. The positive percentage of acidic fibroblast growth factor receptor expression of capillary vessels in acid fibroblast growth factor/fibrin gelatin group was higher than fibrin gelatin group and blank control group. The expressing amount of acidic fibroblast growth factor receptor in acid fibroblast growth factor/fibrin gelatin group was also higher than fibrin gelatin group and blank control group CONCLUSION:Acidic fibroblast growth factor can protect motor end-plate by improving the surrounding blood circulation.

Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. ?-Synuclein was the first"PD gene"to be discovered. The involvement of ?-synuclein in PD was first suspected after two different ?-synuclein mutations were identified in two kindreds with autosomal-dominant PD. However,the discovery that ?-synuclein is the major component of Lewy bodies-pathological hallmarks of PD, confirmed its role in PD pathogenesis. Pathological aggregation of ?-synuclein might be responsible for neurodegeneration. Multiple factors have been shown to affect ?-synuclein aggregation in vitro or in vivo. In addition, soluble oligomers of ?-synuclein might be even more toxic than the insoluble fibrils found in degenerative diseases. So it is significant to investigate factors affecting ?-synuclein aggregation, especially their accurate effects on the aggregation process.

The author reviewed the development of general practice education in our country,deliberated and summarized the problems about the construction of curriculum system,the ranks of teachers and practice base in general practice education in higher medicine colleges.