1.Two Cases of Microvenular Hemanogioma.
Young Koo KIM ; Tae Kee MOON ; Kee Yang CHUNG ; Seung Hun LEE
Korean Journal of Dermatology 1999;37(9):1320-1324
Microvenular hemangioma (MH) is a recently described, uncommon, acquired vascular, tumor presenting clinically as a small reddish nodule in young and middle, aged individuals of either gender. Histologically, thin and irregularly branching small venules with inconspicouous lumia and without cellular atypia are found widely throughout the dermis. The presence of histologic features of the collagen dissection and vascular tufts makes it necessary to differentiate MH with Kaposi's sarcoma and angioblastoma. As we are aware, the description of these two cases which showed the characteristic clinical and histologic features of MH, is the first report of MH in Korea.
Collagen
;
Dermis
;
Hemangioma
;
Korea
;
Sarcoma, Kaposi
;
Venules
2.A Study of Leukocyte Migration Inhibition Factor in Behcet's Syndrome.
Eun So LEE ; Dong Soon YANG ; Seung Hun LEE ; Dong Sik BANG ; Sung Nack LEE ; In Hong CHOI ; Bong Ki LEE ; Jung Koo YOUN
Korean Journal of Dermatology 1988;26(6):804-811
This study was undertaken to investigate the immunological mechanism of Behqet s syndrome, considered to be important in the pathogenesis of the disease. Seventy- three patients with complete, incomplete and suspected types of Behget's syndrotne were tested for leukocyte migration ingibition factor(LIF), one of the lymphokines. The results were as follows : 1. There was no difference between the average LIF activity of all the patients and that of eontrol. 2. LIF activity of complete type, according to Shirnizus classification, was significaritly lower than the control value. 3. LIF activity of ocular type, according to Lehners classification, was signficantly lower than the control value. 4. LIF activity for patients with 4 clinical symptoms was well below the value for patients with less symptomes 5. For patients with single clinical symptom, LIF activity of complete type was well below the values of incomplete and suspected types. 6. In suspected and mucocutaneous types, LIF activity was low when the patients showed two clinical symptoms than one. Thus, LIF activity was low for patients with complete, ocular and neurological types and with multiple symptorns.
Behcet Syndrome*
;
Classification
;
Humans
;
Leukocytes*
;
Lymphokines
3.The Perioperative Management of Antithrombotic Therapies Using Enoxaparin.
Hun Gyu HWANG ; So My KOO ; Soo Taek UH ; Yang Ki KIM
Journal of Korean Medical Science 2017;32(6):942-947
Oral anticoagulant therapy is frequently and increasingly prescribed for patients at risk of arterial or venous thromboembolism (VTE). Although elective surgical or invasive procedures have necessitated temporary interruption of anticoagulants, managing these patients has been performed empirically and been poorly investigated. This study was designed to evaluate the adequacy of perioperative anticoagulation using enoxaparin. This was a retrospective, single-center study that evaluated the efficacy and safety of therapeutic-dose enoxaparin for bridging therapy in patients on long-term warfarin at Soonchunhyang University Hospital in Korea between August 2009 and July 2011. Warfarin was discontinued 5 days before surgery, and enoxaparin was administered twice daily by subcutaneous injection at a dose of 1 mg per kg from 3 days before the procedure to the last dose 24 hours before the procedure. Anticoagulation was restarted if proper hemostasis had been confirmed. There were 49 patients, of whom 25 (51%) were men, and the mean age was 63 years. Thirty-four (69%) received warfarin therapy for VTE, and 9 (18%) for atrial fibrillation. Twenty-nine patients (59%) underwent major surgery and 20 (41%) minor surgery. The mean postoperative duration of enoxaparin was 4 days. No patients had thromboembolic complications through 30 days after the procedure. The overall 30-day mortality rate was 0%. In conclusion, our findings demonstrate that bridging therapy with therapeutic-dose enoxaparin is feasible and associated with a low incidence of major bleeding and no thromboembolic complications. However, the optimal approach to managing patients perioperatively is uncertain and requires further evaluation.
Anticoagulants
;
Atrial Fibrillation
;
Enoxaparin*
;
Hemorrhage
;
Hemostasis
;
Heparin, Low-Molecular-Weight
;
Humans
;
Incidence
;
Injections, Subcutaneous
;
Korea
;
Male
;
Minor Surgical Procedures
;
Mortality
;
Retrospective Studies
;
Thromboembolism
;
Venous Thromboembolism
;
Warfarin
4.Effect of adenotonsillar hypertrophy on snoring in children.
Yang Gi MIN ; Myung Koo KANG ; Hyung Min PARK ; Sun O CHANG ; Hun Jong DHONG ; Ha Won JUNG ; Ic Tae KIM ; Hong Jong KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(1):95-102
No abstract available.
Child*
;
Humans
;
Hypertrophy*
;
Snoring*
5.Selection of Olfactory Identification Items for Koreans.
Kyung Hun YANG ; Young Ah KOO ; Ki Young PARK ; Young Min KIM ; Young Min PARK ; Hyun Joon LIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1998;41(10):1281-1286
BACKGROUND AND OBJECTIVES: The olfactory identification test has been used in clinical assessment of olfactory ability for the following reasons: it is fast, it yields results compatible to a threshold test, and it gives a picture of how well the patient can deal with odors of everyday life. However, items in UPSIT (University of Pennsylvania Smell Identification Test)and CCCRC (Connecticut Chemosensory Clinical Research Center)identification test which are widely used in the world are selected for western people. Accordingly, these items in the tests are not appropriate for Koreans of different cultural background. MATERIALS AND METHODS: For the selection of proper items for the olfactory identification test, 42 natural odors familiar to Koreans were applied to 40 normal subjects and 40 patients with decreased sense of smell without sinonasal diseases. Among 42 items, 16 items with high identifiability and familiarity were chosen according to the results of test-retest in normal subjects. RESULTS: The results of olfactory identification test using 16 selected items showed high correlation with olfactory threshold. CONCLUSION: These 16 items can be used for an olfactory identification test for Koreans.
Humans
;
Odors
;
Pennsylvania
;
Recognition (Psychology)
;
Smell
6.The Diagnostic Value of Ultrasound-Guided Fine Needle Aspiration Cytology in the Thyroid Nodules
Yang Hun KOO ; Sung Jun HONG ; Hwi CHOI ; Hark RIM ; Young Sik CHOI ; Yo Han PARK ; Kyung Seung OH ; Hee Kyung CHANG
Journal of Korean Society of Endocrinology 1996;11(4):391-400
Background: Thyroid nodule is a common disease of thymid gland. The incidence of malignant nodule is about 3%, so most of thyroid nodules are benign. Because most thyroid nodule morbidity is related to cancerous lesions, early detection of malignant nodule is important. However, some of these nodules are srnall sized or deep seated which were not detected by physieal exarnination but by ultrasonography incidentally. In these cases the diagnostic approach is difficult with conventional methods but it is easy with ultrasound-guided fine needle aspiration (FNA). However, the role of ultrasound-guided FNA on the thyroid nodules has been poorly evaluated, so we tried to assess the diagnostic value of high resolution ultrasound-guided FNA in the thyroid nodules. Methods: We examined the medical records retrospectively of all patients who were engaged in high resolution ultrasonography(ATL Ultramark-9, 10 MHz linear transducer) due to thyroid nodules and/or other thyroid abnormalities from September, 1995 to March, 1996. Ultrasound- guided FNA was performed in 137 patients with palpable or nonpalpable(small sized or deep seated) nodules which were detected by high resolution ultrasonography. Results: The mean age of the patients was 45 and most of them were middle aged. Male to female ratio was 1:8.1. Malignant nodules were frequent in patients over 30 yus of age. Of 137 patients 43 were involutional change, 45 hyperplasia, 12 Hashimotos thyroiditis, 12 follicular neoplasm, ll papillary carcinoma, 1 Hurthle cell tumor, 1 medullary carcinoma, and 12 inadequate specimen. In 22 cases thyroid nodules were not detected by physical examinatian but by ultrasonography and in 31 cases additional thyroid nodules were detected by ultrasonography. In the nature of thyroid nodules, 99 cases were solid, 16 cystic, 22 mixed. Malignant nodule were more frequent in the solid nodule, but thete was no significant difference between each group. The size of masses was categorized into four groups. Thirty-one cases measured less than 1cm, 63 between 1cm and 1.9cm, 29 between 2cm to 2.9cm, and 14 over 3cm. The malignant nodule was not palpable in 3 cases and the smallest was 0.7cm in diameter. Most of malignant lesions were between 1cm and 2.9cm, but the difference of incidence rate of rnalignant nodules between each group was not significant. The incidence rate of malignancy was 8.8% in solitary nodule and 8.7% in multiple nodules. Twenty-three cases including 12 malignancies diagnosed by FNA underwent operation. Of those 13 were papillary earcinoma, 1 follicular carcinoma, 1 medullary carcinoma. Upon the correlation of ultrasound-guided FNA cytology with pathologic diagnosis, the sensitivity of ultrasound-guided FNA cytology in differentiating benign and malignant nodule was 80.0%, the specificity 100% and overall diagnostic accuracy was 86.1%. The obtainability of adequate cytologic specimen by ultrasound-guided FNA was 91%. No complication except pain was noted during this study. Conclusion: High resolution ultrasound-guided FNA cytology in the thyroid nodules may be useful in the diagnosis of thyroid cancer especially in the nodules which were small sized or deep seated and also useful in early detection of recurrence of thyroid cancer.
Adenoma, Oxyphilic
;
Biopsy, Fine-Needle
;
Carcinoma, Medullary
;
Carcinoma, Papillary
;
Diagnosis
;
Female
;
Humans
;
Hyperplasia
;
Incidence
;
Male
;
Medical Records
;
Middle Aged
;
Recurrence
;
Retrospective Studies
;
Sensitivity and Specificity
;
Thyroid Gland
;
Thyroid Neoplasms
;
Thyroid Nodule
;
Thyroiditis
;
Ultrasonography
7.A Case of atypical bronchial carcinoid with multiple distant metastasis.
Tae Hun LEE ; Sung Uk YANG ; Tae Kwan LEE ; Byung Koo KIM ; Ji Young KIM ; Kwi Wan KIM ; Kwang Min LEE
Tuberculosis and Respiratory Diseases 1996;43(3):440-448
Branchial carcinoid tumors are uncommon, constituting approximately 3-5% of all primary lung cancers. Classification of these tumors has evolved substantially as our understanding of the cellular, biologic, and clinical aspects of these neoplasms has improved. Initially, bronchial carcinoids were thought to be benign and therefore were classified as branchial adenomas. Currently, however, they are well recognized as having the potential for both local invasion and distant metastatic involvement. Consequently, carcinoid tumors are frankly malignant. Thus bronchial adenoma is a misnomer that should no longer be used for bronchial carcinoids. Most investigators currently favor classifying carcinoid tumors as a type of neuroendocrine neoplasm because of their potential to secrete a variety of chemical substances found in both the central nervous system and the epithelial cells of numerous organs. Bronchial carcinoids are usually characterized by a slow growth pattern and a low incidence of metastasis, and histologically confirmed by the azurophil staining and the presence of the characteristic neurosecretary granule on electron microscopy. Atypical carcinoid tumor was first defined by Arrigoni et al, who proposed the following criteria for separation of atypical carcinoid from typical carcinoid tumor: 1) increased mitotic activity with 1 mitotic figure per 1-2 high power fields (or 5-10 mitoses /10 HPF), 2) nuclear pleomorphism, hyperchromatism, and an abnormal nuclear-cytoplasmic ratio, 3) areas of increased cellularity with disorganization of the architecture, and 4) tumor necrosis. In contrast, typical carcinoid tumor may have focal cytologic pleomorphism, but necrosis is absent and mitotic figures are rare. Recently we experienced a case of atypical bronchial carcinoid with multiple distant metastasis, so we report this case with a review of the literature.
Adenoma
;
Carcinoid Tumor*
;
Central Nervous System
;
Classification
;
Drug Therapy
;
Epithelial Cells
;
Humans
;
Incidence
;
Lung Neoplasms
;
Microscopy, Electron
;
Mitosis
;
Necrosis
;
Neoplasm Metastasis*
;
Research Personnel
8.Clinical Characteristics of 2070 Korean Women Who Visited the Adolescent Gynecology Clinic.
Chel Hun CHOI ; You Young LEE ; Sook Young YANG ; Byung Koo YOON ; Duk Soo BAE ; Doo Seok CHOI
Korean Journal of Obstetrics and Gynecology 2004;47(4):729-738
OBJECTIVE: To analyze the clinical characteristics of Korean pediatric, adolescent and premarital women who visited the Adolescent Gynecology Clinic at Samsung Medical Center. METHODS: A retrospective study was performed on the 2070 women visiting the Adolescent Gynecology Clinic at Samsung Medical Center from Feb. 1995 to Sep. 2003. The patients were divided into 3 groups according to patients' age; group I (~9 years, 258 patients), group II (10-20 years, 911 patients), group III (21-30 years, 901 patients). Clinical characteristics were analyzed by chart review and compared among three groups. RESULTS: The mean patient age was 18.4 +/- 6.9 years (mean SD) and the mean age at menarche was 13.4 +/- 1.5 years. The most common disease entity and disorder according to age groups were infectious disease and vaginitis in group I, menstruation associated problems and abnormal uterine bleeding (AUB) in group II, and menstruation associated problems and amenorrhea in group III. Among gynecologic problems, AUB was cited as the most common problem for the patients visiting the Adolescent Gynecology Clinic (425 cases, 20.5%), followed by amenorrhea (393 patients, 19.0%). 51.0% of primary amenorrhea had a congenital defects. Among the patients with pelvic tumor (293 patients), 85.3% was due to ovarian tumor, and 166 patients (66.4%) with ovarian tumor underwent operation. The most common pathologic diagnosis for ovarian tumor was endometrioma (60 cases, 36.1%). In primary dysmenorrhea (214 patients, 76.2% of total dysmenorrhea), treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) resulted in symptomatic improvement in 82.6% of the patients. The most common infectious disease was vaginitis and the most commonly isolated organisms varied according to age group (group I, II: E. coli, group III: Candida albicans). CONCLUSION: The most common gynecologic problem in korean pediatric, adolescent and premarital women is menstruation related disorders, presenting in 58.8% of patients visiting the Adolescent Gynecology Clinic.
Adolescent*
;
Amenorrhea
;
Candida
;
Communicable Diseases
;
Congenital Abnormalities
;
Diagnosis
;
Dysmenorrhea
;
Endometriosis
;
Female
;
Gynecology*
;
Humans
;
Menarche
;
Menstruation
;
Retrospective Studies
;
Uterine Hemorrhage
;
Vaginitis
9.Incidence of Congenital Anomalies and Diagnosis of Congenital Anomalies by Antenatal Ultrasonography.
Byung Hun KANG ; Jin Gu LEE ; Koo Hyun CHUNG ; Jeong Bo YANG ; Do Young KIM ; Yun Ee RHEE ; Heung Tae NOH
Korean Journal of Obstetrics and Gynecology 2004;47(11):2070-2076
OBJECTIVE: To determine the incidence and types of congenital anomalies and evaluate the efficiency of antenatal ultrasonography for detection of congenital anomalies METHODS: This was a retrospective study, undertaken on 157 cases with congenital anomalies among 5,554 delivered newborns at Chungnam National University Hospital from Jan. 1, 1998 to Dec. 31, 2002. For statistical evaluation, Chi-square test were used. RESULTS: Among the total 5,554 newborns, the overall incidence of congenital anomalies was 2.8%. The incidence of congenital anomalies in birth weights less than 2,500 gm was 9.2% which was 7.5 times higher than that of birth weights more than 2,500 gm. The incidence of congenital anomalies in stillbirth was 19.3% which was 8.2 times higher than that of the live birth. When classified according to the type of congenital anomalies, the incidence of congenital anomalies were 26.5%, 21.0%, 19.8%, 13.0%, 7.4%, 6.2%, 3.7%, and 2.5% respectively in urogenital system, central nervous system, digestive system, cardiopulmonary system, dermatologic system, musculoskeletal system, chromosomal anomaly syndrome, and fetal tumor. Among 157 cases of congenital anomaly babies, anomaly babies were detected antenatally by ultrasonographic examination in 122 cases, and then the rate of antenatal ultrasonographic detection was 77.7%. CONCLUSION: The overall incidence of congenital anomalies was 2.8%. The most common congenital anomalies were urogenital anomalies. The rate of antenatal ultrasonographic detection for congenital anomalies was 77.7%.
Birth Weight
;
Central Nervous System
;
Chungcheongnam-do
;
Diagnosis*
;
Digestive System
;
Humans
;
Incidence*
;
Infant, Newborn
;
Live Birth
;
Musculoskeletal System
;
Prenatal Diagnosis
;
Retrospective Studies
;
Stillbirth
;
Ultrasonography*
;
Urogenital System
10.Infrared Thermography in the Assessment of Temporomandibular Joint Dysorder.
Francis Sahngun NAHM ; Mi Suk KOO ; Yang Hyun KIM ; Jeong Hun SUH ; Hwa Yong SHIN ; Yong Min CHOI ; Yong Chul KIM ; Sang Chul LEE ; Pyung Bok LEE
The Korean Journal of Pain 2007;20(2):163-168
BACKGROUND: Temporomandibular joint disorder (TMD) is a group of musculoskeletal conditions characterized by pain in the pre-auricular area, limitation of jaw movement and palpable muscle tenderness. Thermography is a nonionizing, noninvasive diagnostic alternative for the evaluation of TMD. This study was conducted to evaluate the usefulness of thermography in the assessment of TMD. METHODS: Thermography was conducted on the 61 patients who had been diagnosed with TMD, and on the 34 normal symptom-free volunteers. The temperature differences between opposite sides of the temporomandibular joint (DeltaTTMJ) and the masseter muscle (DeltaTMST) were calculated. The sensitivity and specificity of thermography was calculated at the cut off values of 0.2, 0.3, and 0.4 degrees C. RESULTS: In the patient group, the DeltaTTMJ was 0.42 +/- 0.38 degrees C and the DeltaTMST was 0.38 +/- 0.33 degrees C, whereas in the control group the DeltaTTMJ was 0.10 +/- 0.07 degrees C and the DeltaTMST 0.15 +/- 0.10 degrees C. In addition, the patient group demonstrated a significantly lower level of thermal symmetry than the control group (P < 0.001) in both the temporomandibular joints and the masseter muscles. The sensitivity of thermography at the cut off values of 0.2, 0.3 and 0.4 degrees C was 67.2, 49.2, and 42.6% in the temporomandibular joint (TMJ) and 60.7, 49.2 and 37.7% in the masseter muscle, respectively. The specificity of thermography at the cut off values of 0.2, 0.3 and 0.4 degrees C was 88.2, 100, and 100% in the TMJ and 61.8, 91.2 and 100% in the masseter muscles, respectively. The accuracy of thermography at the cut off values of 0.2, 0.3 and 0.4 degrees C was 74.7, 67.4, and 63.2% in TMJ and 61.1, 64.2 and 60.0% in the masseter muscles, respectively. CONCLUSIONS: Temperature differences exist between the opposite sides of the TMD and masseter muscles in patients with TMD. Although the sensitivity of thermography in the diagnosis of TMD is low, it has high specificity in the evaluation of TMD, and is therefore applicable to patients with TMD.
Diagnosis
;
Diagnostic Imaging
;
Humans
;
Jaw
;
Masseter Muscle
;
Myalgia
;
Sensitivity and Specificity
;
Temporomandibular Joint Disorders
;
Temporomandibular Joint*
;
Thermography*
;
Volunteers