1.AIDS-related recognition among the general population in Korea.
Be Long CHO ; Byung Goog YANG ; Hoon Ki PARK ; Seong Won KIM ; Tai Woo YOO ; Bong Yul HUH
Journal of the Korean Academy of Family Medicine 1993;14(10):670-679
No abstract available.
Korea*
2.Clinical Characteristics of Hypernatremia.
Jeong Hoon KIM ; Un Sil JEON ; Jin Suk HAN ; Jae Seok YANG ; Seo Jin LEE ; Curie AHN ; Suhnggwon KIM ; Jung Sang LEE ; Woo Seong HUH ; Jong Ho LEE
Korean Journal of Nephrology 1998;17(4):553-558
Hypematremia is a rare but important medical condition and is associated with mortality rate of 40 to 70%. However, little has been known about its prognostic factors or treatment guidlines. To evaluate the prognostic factors and the outcome following treatment, we reviewed 22 available medical records among twenty five hypernatremic patients (0.2%) in 12841 admissions at medical ward from January to December 1995. We defined hypernatremia as serum sodium concentration more than or equal to 150 mEq/L. Of these patients, two had hypematrernia at admission and the remaining patients became hypernatremic during admission. Mean peak serum sodium concentration was 158 (150-178) mEq/L and mean total body water deficit was 11.4 (6.7-21.3)%. Factors correlated with the development of hypernatremia were diverse and multiple, and the most frequent factor was diminished access to water. Mortality rate was 59%, but mortality was not correlated with age, correction rate of hyper-natremia, primary route of fluid loss, and the severity of hypernatremia or total body water deficit. Mortality rate was higher in patients whose serum sodium concentrations were below 130 mEq/L at admission (P<0.05). In our study, development of hypernatremia from initial hyponatremic state was significantly associated with poor outcome, and age, rapidity of correction, route of fluid loss, and the severity of hypernatremia or total body water deficit were not.
Body Water
;
Humans
;
Hypernatremia*
;
Medical Records
;
Mortality
;
Sodium
;
Water
3.Phase I study of subcutaneously administered recombinant human granulocyte-macrophage colony stimulating factor(GM-CSF) in patients with advanced malignancy.
Jung Ae LEE ; Hyun Ah KIM ; Kyung Hoon LEE ; Sung Hyun YANG ; Dae Suk HUH ; Young Joo BANG ; Byung Kook KIM ; No Kyung KIM
Journal of the Korean Cancer Association 1993;25(4):520-530
No abstract available.
Humans*
4.Severity-Adjusted Dexamethasone Dosing and Tocilizumab Combination for Severe COVID-19
Jin Yeong HONG ; Jae-Hoon KO ; Jinyoung YANG ; Soyoung HA ; Eliel NHAM ; Kyungmin HUH ; Sun Young CHO ; Cheol-In KANG ; Doo Ryeon CHUNG ; Jin Yang BAEK ; You Min SOHN ; Hyo Jung PARK ; Beomki LEE ; Hee Jae HUH ; Eun-Suk KANG ; Gee Young SUH ; Chi Ryang CHUNG ; Kyong Ran PECK
Yonsei Medical Journal 2022;63(5):430-439
Purpose:
Real-world experience with tocilizumab in combination with dexamethasone in patients with severe coronavirus disease (COVID-19) needs to be investigated.
Materials and Methods:
A retrospective cohort study was conducted to evaluate the effect of severity-adjusted dosing of dexamethasone in combination with tocilizumab for severe COVID-19 from August 2020 to August 2021. The primary endpoint was 30-day clinical recovery, which was defined as no oxygen requirement or referral after recovery.
Results:
A total of 66 patients were evaluated, including 33 patients in the dexamethasone (Dexa) group and 33 patients in the dexamethasone plus tocilizumab (DexaToci) group. The DexaToci group showed a statistically significant benefit in 30-day clinical recovery, compared to the Dexa group (p=0.024). In multivariable analyses, peak FiO2 within 3 days and tocilizumab combination were consistently significant for 30-day recovery (all p<0.05). The DexaToci group showed a significantly steeper decrease in FiO2 (-4.2±2.6) than the Dexa group (−2.7±2.6; p=0.021) by hospital day 15. The duration of oxygen requirement was significantly shorter in the DexaToci group than the Dexa group (median, 10.0 days vs. 17.0 days; p=0.006). Infectious complications and cellular and humoral immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the convalescence stage were not different between the two groups.
Conclusion
A combination of severity-adjusted dexamethasone and tocilizumab for the treatment of severe COVID-19 improved clinical recovery without increasing infectious complications or hindering the immune response against SARS-CoV-2.
5.Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes.
Jin Oh KWAK ; Woon Kyu LEE ; Hyun Woo KIM ; Sun Mi JUNG ; Kwang Jin OH ; Sang Yong JUNG ; Yang Hoon HUH ; Seok Ho CHA
Journal of Korean Medical Science 2006;21(1):100-106
The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes. In normal rat chondrocytes, we observed relatively high levels of Cav-3 and a very low level of COX-2 mRNA and protein. Upon treating the chondrocytes with 5 microM of CdCl2 (Cd) for 6 hr, the expressions of COX-2 mRNA and protein were increased with the decreased Cav-3 mRNA and protein expressions. The detergent insoluble caveolae-rich membranous fractions that were isolated from the rat chondrocytes and treated with Cd contained the both proteins of both COX-2 and Cav-3 in a same fraction. The immuno-precipitation experiments showed complex formation between the COX-2 and Cav-3 in the rat chondrocytes. Purified COX-2 with glutathione S-transferase-fused COX-2 also showed complex formation with Cav-3. Confocal and electron microscopy also demonstrated the co-localization of COX-2 and Cav-3 in the plasma membrane. The results from our current study show that COX-2 and Cav-3 are co-localized in the caveolae of the plasma membrane, and they form a protein-protein complex. The co-localization of COX-2 with Cav-3 in the caveolae suggests that the caveolins might play an important role for regulating the function of COX-2.
Animals
;
Animals, Newborn
;
Blotting, Western
;
Cadmium Chloride/pharmacology
;
Caveolae/drug effects/metabolism/ultrastructure
;
Caveolin 3/*genetics/metabolism
;
Cell Membrane/drug effects/metabolism
;
Cells, Cultured
;
Chondrocytes/cytology/drug effects/*metabolism
;
Cyclooxygenase 2/*genetics/metabolism
;
Gene Expression
;
Immunoprecipitation
;
Microscopy, Confocal
;
Microscopy, Electron
;
RNA, Messenger/genetics/metabolism
;
Rats
;
Reverse Transcriptase Polymerase Chain Reaction
6.A Clinical and Radiologic Study of Acute Focal Bacterial Nephritis in Children.
Kum Ho SONG ; Kwon Hoe HUH ; Ok Yeon CHO ; Jae Hoon SIM ; Do Jun CHO ; Dug Ha KIM ; Ki Sik MIN ; Ki Yang YOO ; Kwan Seop LEE
Journal of the Korean Pediatric Society 2003;46(4):351-357
PURPOSE: To raise awareness of the clinical importance of, and the need for proper management of acute focal bacterial nephritis(AFBN), we analyzed 22 AFBN patients and 22 other upper urinary tract infection patients by use of comparative studies. METHODS: From January 2000 to May 2002, 22 AFBN patients aged from 1 month to 12 months were selected. As a control group, 22 UTI patients with no radiologic abnormalities were selected and matched by age and sex. RESULTS: The incidence of AFBN was more common in boys than in girls. Since both groups had similar symptoms, it was difficult to diagnose AFBN by clinical presentations alone. ESR and CRP were significantly higher in AFBN patients. The most common causative organism was E. coli in both groups. On the sonographic findings, the most lesions were seen on the upper lobe of the kidney; more frequently, on left kidney. The lesions showed globular or wedge-shaped increased echogenecity. 99mTc-DMSA scan showed the complete coincidence of the location, size and shape in all cases compared to the findings of renal sonography. CONCLUSION: The roles of renal sonography and DMSA scan were very important, and ultrasonography was an excellent initial tool in diagnosing AFBN. Since the degree of infection in AFBN is more severe than other urinary tract infections and evollution into a renal abscess is possible, early diagnosis and appropriate antibiotics therapy is essential.
Abscess
;
Anti-Bacterial Agents
;
Child*
;
Early Diagnosis
;
Female
;
Humans
;
Incidence
;
Kidney
;
Nephritis*
;
Succimer
;
Technetium Tc 99m Dimercaptosuccinic Acid
;
Ultrasonography
;
Urinary Tract Infections
7.Successful Chemotherapy Following Autologous Stem Cell Transplantation in Multiple Myeloma and Multi-organ Dysfunction with Infiltration of Eosinophils: A Case Report.
Ho Sup LEE ; Lee Chun PARK ; Seong Hoon SHIN ; Sang Uk LEE ; Hee Kyung CHANG ; Bang HUH ; Gyoo Sik JUNG ; Mi Hyang KIM ; Yang Soo KIM
Cancer Research and Treatment 2011;43(3):199-203
Eosinophils are derived from hematopoietic stem cells. Peripheral blood eosinophilia is defined as an absolute eosinophil count of > or =0.5x10(9)/L. Eosinophilia is classified into primary or clonal eosinophilia, secondary eosinophilia, and idiopathic categories including idiopathic hypereosinophilic syndrome. Both hematopoietic and solid neoplasms may be associated with peripheral blood eosinophilia, but multiple myeloma is rarely associated with eosinophilia. We now report the case of a 31-year-old man with multiple myeloma associated with marked eosinophilia who developed multiple organ dysfunction with infiltration of eosinophils. He recovered after treatment with chemotherapy followed by autologous stem cell transplantation.
Adult
;
Eosinophilia
;
Eosinophils
;
Hematopoietic Stem Cells
;
Humans
;
Hypereosinophilic Syndrome
;
Multiple Myeloma
;
Stem Cell Transplantation
;
Stem Cells
;
Transplantation, Autologous
8.Successful Chemotherapy Following Autologous Stem Cell Transplantation in Multiple Myeloma and Multi-organ Dysfunction with Infiltration of Eosinophils: A Case Report.
Ho Sup LEE ; Lee Chun PARK ; Seong Hoon SHIN ; Sang Uk LEE ; Hee Kyung CHANG ; Bang HUH ; Gyoo Sik JUNG ; Mi Hyang KIM ; Yang Soo KIM
Cancer Research and Treatment 2011;43(3):199-203
Eosinophils are derived from hematopoietic stem cells. Peripheral blood eosinophilia is defined as an absolute eosinophil count of > or =0.5x10(9)/L. Eosinophilia is classified into primary or clonal eosinophilia, secondary eosinophilia, and idiopathic categories including idiopathic hypereosinophilic syndrome. Both hematopoietic and solid neoplasms may be associated with peripheral blood eosinophilia, but multiple myeloma is rarely associated with eosinophilia. We now report the case of a 31-year-old man with multiple myeloma associated with marked eosinophilia who developed multiple organ dysfunction with infiltration of eosinophils. He recovered after treatment with chemotherapy followed by autologous stem cell transplantation.
Adult
;
Eosinophilia
;
Eosinophils
;
Hematopoietic Stem Cells
;
Humans
;
Hypereosinophilic Syndrome
;
Multiple Myeloma
;
Stem Cell Transplantation
;
Stem Cells
;
Transplantation, Autologous
9.The Short Term Growth of Neo-aorta and its Implication to Aortic Insufficiency after Arterial Switch Operation in Complete Transposition of Great Arteries.
Sung Hoon KIM ; June HUH ; I Seok KANG ; Heung Jae LEE ; Ji Hyuk YANG ; Tae Gook JUN ; Pyo Won PARK
Journal of the Korean Pediatric Cardiology Society 2007;11(3):206-214
PURPOSE: This study was aimed to assess the growth of neo-aorta and its implication to neo-aortic insufficiency in children with complete transposition of great arteries (TGA) after arterial switch operation (ASO). METHOD: We retrospectively reviewed medical records, echocardiograms and cardiac catheterization of 40 patients who had underwent ASO at Samsung Medical Center from 1995 through 2001. Pulmonary artery and aorta were evaluated regarding its stenosis and regurgitation, respectively. The growth of the neo-aortic valve, sinus of neo-aortic Valsalva, and the site of aortic anastomosis were evaluated by measuring the change of the diameter. RESULT: The mean duration of follow-up after ASO was 17.2+/-12.4 months (range 1.2-67 months). Aortic insufficiency (AI) developed in 45%, in which all were mild. The neo-aortic annulus (originally pulmonary annulus) had grown as normal pulmonic valve does do (diameter of pulmonary valve annulus preoperatively, 8.9+/-1.22 mm; postoperatively at more than 6 months, 12.8+/-2.2mm). The anastomotic site of neo-aorta showed a growth curve equivalent to that of sinotubular junction of normal aorta (preoperative diameter, 7.7+/-1.4 mm; postoperatively at more than 6months, 12.7+/-3.1mm). However, the growth rate of sinus of Valsalva showed a extremely higher compared to that of normal aorta (preoperative diameter, 10.5+/-1.2 mm; postoperatively at more than 6 months, 18.8+/-2.6 mm). No significant relations could be revealed between the change of dimension of aortic root and aortic insufficiency. CONCLUSION: Aortic insufficiency was not uncommon but mild aortic dilatation was not significantly associated with AI. Although the short term result is encouraging, long-term surveillance for aortic root dilatation and aortic insufficiency remains necessary.
Aorta
;
Cardiac Catheterization
;
Cardiac Catheters
;
Child
;
Constriction, Pathologic
;
Dilatation
;
Follow-Up Studies
;
Humans
;
Medical Records
;
Pulmonary Artery
;
Pulmonary Valve
;
Retrospective Studies
;
Sinus of Valsalva
;
Transposition of Great Vessels*
10.Double Stent Assist Coiling of Ruptured Large Saccular Aneurysm in Proximal Basilar Artery Fenestration.
Woong Bae PARK ; Jae Hoon SUNG ; Joon HUH ; Chul Bum CHO ; Seung Ho YANG ; Il Sup KIM ; Jae Taek HONG ; Sang Won LEE
Journal of Cerebrovascular and Endovascular Neurosurgery 2015;17(3):227-233
Basilar artery fenestration is infrequent and even rarer in association with a large aneurysm. With proximity to brain stem and vital perforators, endovascular coiling can be considered first. If the large ruptured aneurysm with a wide neck originated from fenestra of the proximal basilar artery and the fenestration loop has branches of posterior circulation, therapeutic consideration should be thorough and fractionized. We report endovascular therapeutic details for a case of a ruptured large saccular aneurysm in proximal basilar artery fenestration.
Aneurysm*
;
Aneurysm, Ruptured
;
Basilar Artery*
;
Brain Stem
;
Intracranial Aneurysm
;
Neck
;
Stents*