Aim To evaluate the academic level and the popularity of Chinese Pharmacological Bulletin. Method According to the information of Chinese Medical citation Index(CMCI), I statistically analyzed the amount and distribution of the originals in Chinese Pharmacological Bulletin cited by the journal included by CMCI. Result The originals of Chinese Pharmacological Bulletin were high-qualified and influential, and their authors were all over the country. Conclusion With the unique style and character chinese Pharmacological Bulletin is the main medical core periodical and one of the most important information recourses in the field of Pharmacological in china.

Aim To understand the information absorbency of Chinese Pharmacological Bulletin, analyze the theoretical sources of its’ published articles and the trend of Pharmacological research , and find out the characteristics of literature request of the scientists working in the field of Pharmacological research. Method The citation analysis is used to analyze the references cited in 847 articles in Chinese Pharmacological Bulletin from 2001～2003. Result Citation rate is 85.24%, and 11.02 citations per article. Main types of citations are journals(94.88%) and books(4.90%). The Price Index is 42.72%, the self-citation rate is 3.81%. The references from the high-ranked 30 journals are the 30.14% of all the references. Conclusion The articles in Chinese Pharmacological Bulletin concern the lots of journals in the biomedicine, most citation are from the English journals, and the half-cited life is longer than other journals, citation ratio should be improved.

Objective To investigate the effect of glutamic acid (monosodium glutamate,MSG) on Tourette's syndrome (TS). Methods These rats were divided into 2 groups: one group with acute intracerebroventricularly injection (ICV) of MSG or artificial cerebrospinal fluid (CSF), and another group with chronic administration of MSG in a dose of 40 mg/kg in drinking water everyday. Observers who were blind to the two- part subjects assessed the scores of TS- like stereotyped locomotion. Results 1. These groups of 100 ?g or 200 ?g glutamic acid may induce significant TS - like stereotyped locomotion ( P

Objective To study the long term results of thoracolumbar fractures treatment with AF (atlas fixator) pedicle system. Methods The clinical results of 60 cases of thoracolumbar fractures treated with AF pedicle system from 1996 2000 were analyzed retrospectively. Results The follow ups lasted from 3 to 6 years, averaging 4 years. The neurological function improved by at least 2 ASIA grades in 27 cases and by 1 ASIA grade in 33 cases. The correction of the vertebral body height averaged 95.1%, and the correction loss averaged 19.7%. Degeneration and narrowing of the disc space next to the fractured vertebrae were common, and correction loss was most evident at the upper disc spaces. Conclusions The AF pedicle system can achieve good long term clinical results for the recovery of neurological function and the vertebral body height. But the rates of implant failure and correction loss are still high probably due to deficiency of bone grafting and delayed implant removal.

[Objective]To find out the new method to cure the intervertebral discs degeneration by way of the eletron microscope study of the degeneration of the cartilage endplate in the circumstances of the intervertebral destabilization. [Method]To choose forty-eight white macrotia rabbits of Japan,which weighed within the range of 2.5?0.2 kg,female and male was unrestricted.These rabbits were divided into 2 groups randomly,with 21 rabbits in the contrast troup,with 27 rabbits in the experimental group.First 27 rabbits of the experimental group were destabilizated by operated on L6、7.Inj Diazepam 0.25 mg/kg,Inj Ketamine 0.02 g/kg and Inj Atropine 0.125 mg/kg was one by one injected into the rabbit through the auris vein,shearing the rabbit hair of backside waist,fixing the rabbit on operation table in face lying,using 1% Povidone Ioding to degerm the operation area.Every rabbit was incised at the backside of its waist,that incisal opening is located in the center of the intervertebral space(L6、7 space) that both side iliac crest line correspond,from the meso-ordinate direction cut about 4 cm incision,cutting open skin and subcutaneous tissue,thoroughly,exposing the spinous processes the vertebral plates and the upper-inferior articular processes,entirely segregating the muscles that cohere the spinous processes the vertebral plates and the articluar process,then excising the supraspinal ligaments and interspinal ligaments,biting off two sides the inferior articular processes of L6,in order that resulting in intervertebral destabilization,using 0.9% Inj.Sodium Chloride to washout the incisal opening,in order sewing up each layer tissues.After operation rabbits can freely move in the cages.To draw the materials from all groups after two months,four months and six months orderly.Using transmission electron microscope to observe the structure the cartilage endplate,the author should judge the degenerative course and mechanism of the cartilage endplate synthetically.[Result]The intervertebral destabilization can cause the collagen fibers degenerates from the regular and compact structure to the disorder and loose structure.[Conclusion]The intervertebral destabilization can distinctly lead to the degeneration of the cartilage endplate.

Objective To know the pollution of microcystin(MC) in Yanghe reservoir during the period of water blooms in the summer of 2007 and to find the variation characteristics about the pollution.Methods The microcystin concentration was determined by ELISA Kit.A 49 consecutive days monitoring was conducted during Jul.-Aug.,2007.Results The concentration of MC in Yanghe reservoir ranged from 0.13 ?g/L to 0.93 ?g/L,and its average level was(0.26 ?0.13)?g/L.As well as,the concentration of MC in Yanghe reservoir descended fluctuant.Conclusion Water in Yanghe reservoir was polluted by MC.All monitoring results of MC concentration during seven weeks(49 days) did not exceed the limit value of microcystin toxin,1 ?g/L for MC-LR,the grade two water ruled in China Environmental Quality Standard for Surface Water.The basic data for changing regularity of MC studied in the present paper will be useful for the warning of alga pollution.

Objective To explore the microsurgical technique in managing medial sphenoid ridge meningioma.Methods The clinical data of 23 cases of medial sphenoidal ridge meningioma were analyzed retrospectively.The main points of microsurgical treatment of medial sphenoid ridge meningioma were discussed.Results Of 23 cases of medial sphenoid ridge meningiomas,total removal was made in 15 cases,subtotal removal in 6 cases and partial removal in 2 cases.The microsurgical outcomes were satisfactory in all the patients and no patients died.Conclusion The microsurgery via the pterional approach to the medial sphenoid ridge meningiomas can greatly heighten total resection rate of the tumors.Total resection of the tumor depends on its position,character and degree of edema of surrounding tissues.Palliative operations combined with postoperative radiotherapy should be carried out for treating the tumors that can only be subtotally and partially removed.

0.05).Conclusion The peptide growth factors can activate the Akt kinase by phosphorylation.This process depends on the production of H2O2 and the presence of PTEN.

ObjectiveTo investigate the practical value of non-invasive positive pressure ventilation (NIPPV) in the treatment of acute left heart failure(ALHF).MethodsThe clinical effects and complications of NIPPV performed on 36 cases with severe ALHF on the basis of conventional treatment were evaluated and compared with previous treatment without NIPPV.ResultsOf 36 cases with ALHF treated by NIPPV,30 cases improved,6 cases were altered to receive invasive ventilation or dead.Total effective rate was 83.3%.Compared with 42 cases with severe ALHF treated only by conventional treatment in the past 5 years,with only 26 cases being successfully salvaged and effective rate being 61.9%,significant difference (P

Objective To explore the diagnostic value of the quantitative detection of serum miRNA-193a in pulmonary adenocarcinoma.Methods 40 pulmonary adenocarcinoma patients and 40 healthy people were recruited to receive quantitative detection of serum miRNA-193a and CEA.And then the relationship between the concentration of miRNA-193a and CEA was analyze by spearman correlation analysis.12 of the 40 patients underwent operation and the different levels of miRNA-193a expression among pulmonary adenocarcinoma tissues,adjacent tissues and normal tissues was detected by qRT-PCR.The different miRNA-193a levels were compared among groups of by t-test.The diagnostic performance of miRNA-193a was evaluated with receiver operating characteristic curves(ROC) and the area under the curve (AUC) and its 95%CI were calculated.Results The relative expressions of miRNA-193a in pulmonary adenocarcinoma tissues,adjacent tissues and normal tissues were 1.07±0.16;0.80±0.10;0.11±0.07.miRNA-193a expression in pulmonary adenocarcinoma tissues was significantly lower than that in other two groups(P<0.05).The expression of serum miRNA-193a in pulmonary adenocarcinoma group was significantly lower than that in healthy group(P<0.05).There was no correlation between miRNA-193a and CEA(r=0.079,P=0.618).The detection of miRNA-193a yielded a ROC AUC of 0.829(0.741-0.917) in discriminating pulmonary adenocarcinoma from healthy group.Conclusion The relative expression of miRNA-193a in pulmonary adenocarcinoma was significantly lower than that in healthy controls no matter in tissue or serum,serum miRNA-193a may prove to be a non-invasive biomarker for the auxiliary diagnosis of pulmonary adenocarcinoma.