Objective To study the protective effect of leuprorelin particle on ovarian reserve function applied before the laparoscopic cystectomy of ovarian endometriosis.Methods 106 patients with endometriosis treated from January 2015 to December 2015 in our hospital were selected.The subjects were divided into two groups according to the random number table, 53 cases of each group.The control group adopted the laparoscopic surgery;the observation group took the leuprorelin particle before the laparoscopic surgery.The operation condition, ovarian hormone and function were observed. Results The operation time and bleeding amount in observation group was better than control group ( P <0.05 ) .After surgery, the exhaust time between two groups had no significantly different.After surgery, the level of follicle stimulating hormone (FSH) in observation group was lower than control group; the level of estradiol (E2) in observation group was higher than control group (P <0.05); the level of luteinizing hormone (LH) between two groups had no significantly different.After surgery, the ovarian volume and antral follicle count ( AFC) in observation group was better than control group (P<0.05).Conclusion Before the laparoscopic cystectomy of ovarian endometriosis, the leuprorelin particle protects the ovarian function and morphology and has less impact in the level of hormone.

Objective To discuss the feasibility and safety of minimally invasive direct coronary artery bypass grafting (MIDCABG). Methods A total of 33 patients underwent small incision, off-pump, single-vessel direct coronary artery bypass grafting in this hospital from March 2001 to September 2003. Left anterior small thoracotomy was adopted in 14 patients, whereas partial midline sternotomy was conducted in 19 patients. The left internal mammary artery was anastomosed to the anterior descending artery in 31 patients, construction of the aorta root-anterior descending artery anastomosis using the great saphenous vein was carried out in 1 patient, and the right gastroepiploic artery was anastomosed to the posterior descending artery in 1 patient. Results The operative mortality was a zero. The intraoperative blood loss was 163?120 ml, and the postoperative drainage, 193?169 ml. The assisted respiration time after operation was 6 4?5 5 hours and the duration in ICU was 17 8?4 4 hours. Follow-up for 14 7?7 4 months found no deaths. Conclusions MIDCABG is a safe and reliable procedure, offering minimal invasion, less blood loss and fewer complications.

Objective To investigate the significance of bone mineral changes in the pathogenic process of glucocorticoid-induced avascular necrosis of femoral head(GANFH).Methods Thirty-two New Zealand rabbits were randomly divided into two groups(16 each).Animals in model group received an intramuscular injection of hydrocortisone acetate(8.0mg/kg) twice a week for 8 weeks totally,and animals in control group received an intramuscular injection with the same volume of normal saline,while 150kU penicillin were injected twice a week for preventing infection in both groups.The contents of serum calcium(Ca) and phosphorus(P) were determined,and the bone mineral densities of the femoral head and neck were measured at the 2nd,4th,6th,8th and 12th weeks after treatment.Meanwhile,the general condition such as weight,spirit and hair of rabbits was observed.Results Compared with the control group,the weight of rabbits in model group lost since the first week,and progressively aggravated;the bone mineral density of the femoral head and neck lowered since the 2nd and 4th week respectively(P

Objective To investigate the clinical significance of cell function changes of bone tissue in glucocorticoid-induced avascular necrosis of femoral head(GANFH),and the preventive and therapeutic effects of "Cugusugao" ointment,a mixture of traditional Chinese medicines,on GANFH.Methods Sixty-four New Zealand white rabbits were randomly divided into four groups(16 each): control group,model group,therapy group and prevention group.The contents of bone-specific alkaline phosphatase(BSAP) and bone gla protein(BGP),and the activity of tartrate-resistant acid phosphatase(TRAP) in serum were determined at the 0,2nd,4th,6th,8th and 12th week after treatment.Meanwhile,rabbits were sacrificed at the 4th,6th,8th and 12th week,and bilateral femoral heads were obtained for histopathological examination.Results Compared with control group,the contents of serum BSAP were elevated at the 4th and 6th week,while TRAP elevated from the 2nd week and BGP lowered from the 4th week in model group(P

CCN1 is a novel extracellular matrix-associated signaling protein which possesses 381 amino-acid residues to compose 4 distinct structural modules with 38 conserved cysteine residues.This protein has a variety of properties in cardiovascular system,affecting the cellular behaviors such as differentiation,proliferation and migration of vascular endothelial cells,smooth muscle cells and cardiac myocytes,that suggested an essential roles of CCN1 in angiogensis,vascular injury,cardiac development and myocardial infarction.

Objective To investigate the changes of cervical vagal efferent discharge induced by lipopolysaccaride in rats. Methods Ten rats were randomly divided into two groups, receiving lipopolysaccaride (5 mg/kg) or normal saline through intravenous injection. Frequency of cervical vagal efferent discharge was recorded at 30 min, 1, 2 and 4 h after the injection. Results The frequency of cervical vagal efferent discharge was significantly increased after LPS injection (P

According to the anatomic classification,refractive surgery is divided into keratorefractive surgery,phakic refractive surgery and scleral refractive surgery.Most procedures for the correction of ametropia are performed on the cornea,with laser-assisted in situ keratomileusis(LASIK) being the most common one.LASIK has shown its limitations,however.For the correction of higher myopic and hyperopic refractive error,the procedure has considerable undesired effects,such as loss of contrast,glare,and iatrogenic keratectasia.Therefore,a variety of intraocular lens,known as phakic refractive surgery,have been designed to achieve full correction of high myopia and hyperopia without loss of accommodation.Phakic refractive surgery is different from kerato-or scleral refractive surgery in that it involves phakic intraocular lens,non-phakic intraocular lens and clear lens extraction +introcular lens.The author will outline recent progress in phakic intraocular lens and provide unifying concepts that are accepted by ophthalmologists.

BACKGROUND:Wear particles factually serve as a medium carrying extensive information on the wear process involved in hip implants.Moreover,it has been demonstrated that wear particles contribute to the failure of Charnley total hip replacement.OBJECTIVE:To investigate the morphological characteristics of wear particles generated by couples of ultrahigh molecular weight polyethylene(UHMWPE) cups and Al2O3 femoral heads,mounted in a simulator in the presence of distilled water and explore the wear mechanism of UHMWPE cup.DESIGN:Wear tests were performed on a ball-in-socket hip simulator.SETTING:Department of Mechanical Engineering,Xuzhou Institute of Technology.MATERIALS:The molecular weight of UHMWPE selected as cup was 3 000 000.Its density was 0.935 g/cm3,hardness 30 HB,fracture strength 35 MPa,and water absorption 450 MPa,and tenacity 7 MPaM1/2.METHODS:The experiment was performed in the laboratory of tribology,China University of Mining and Technology from December 2003 to July 2005.Hip simulator was used to assess the tribological performance of Al2O3-UHMWPE at room temperature,100 r/min,784 N load for 1.5?106 cycles.Distilled water was used as the lubricant.Wear of UHMWPE acetabulum was measured every 3?105 cycles by taking out the acetabulum from simulator,cleaning in distilled water for 3 minutes in an ultrasonic bath,putting in an oven for 40 minutes at 80 ℃,and cooling off in a desiccator.A BT211D electronic balance(reciprocal sensibility,0.01 mg) was used to measure the weight loss of UHMWPE acetabula according to the reference sample method to calculate the wear.A sample(20 mL) of distilled water lubricant used in test was obtained when the simulator was stopped for gravimetric analysis.Morphology of wear particles in samples and surface of worn UHMWPE acetabula were observed by using scanning electron microscope(SEM).The components of wear particles were determined by X-ray.Detailed measurements of the wear particles distribution were conducted by LS100(R) Laser Particle Size Analyzer(including LS SVM Plus).MAIN OUTCOME MEASURES:Morphology and size distribution of wear particles;Wear mechanism and wear rate of UHMWPE acetabula.RESULTS:The wear particles showed a wide range of particle sizes,varying from 0.3 to 180 ?m,most of which ranged from 5 to 20 ?m.More than 99% of wear particles were UHMWPE particles,which were classified into five groups in terms of their morphological characteristics:spherical particle,tearing particle,lamellar particle,fatigued flaking and rod-shaped particle.Lamellar or cube was the predominant form of Al2O3 ceramic particles with flat surface structure and upright edges.The worn surfaces of UHMWPE cup showed evidence of multidirectional scratching,adhesive and micro-contact fatigue wear,and plastic deformation.CONCLUSION:①The dominant wear mechanisms acting in the UHMWPE cup are abrasive wear,adhesive wear,microcosmic fatigue wear and flaking associated with plastic deformation.②The size of particles accumulating mostly is tiny among the particle groups.

Objective To explore the clinical manifestations, CT features, and inheritance pattern of Fahr disease. Methods Head CT was scanned and serum calcium and phosphorum were measured in 14 persons from 2 families, and the 2 families' history was investigated. Results The serum calcium and phosphorum were normal in the 14 persons. There were 8 cases of Fahr disease, and the head CT showed local or diffuse calcium deposition in bilateral basal ganglia, subcortex, and thalamus, respectively. The inheritance pattern of the 8 cases of Fahr disease in the two families showed holandric inheritance, The clinical symptom and sign included seizures, irritability, mental retardation or no abnormal findings. Conclusion Fahr disease is a hereditary disease characterized by idiopathy and calcium deposition in the central nervous system. The clinical feature is various and head CT is an important examination in the diagnosis of Fahr disease.

Yersinia pestis is the pathogen of plague which has caused three pandemics in human history. Understanding the evolution of Y. pestis in different plague foci from the genomic point of view is of deep significance in improving detection, identification, prevention and treatment of plague. The results of the study of genomic evolution of Y.pestis and their practical implications are discussed in this paper. [HS(1*2/3]