Sepsis,a common clinical syndrome,comparing to septicaemia or bacteremia,has a more comprehensive pathophysiological process.Its pathogenesis is complex,including pro-inflammatory/anti-inflammatory cytokine imbalance,intestinal bacterial translocation,immunosuppression,signal pathway activation,etc.Further study on the pathogenesis of sepsis is the theory foundation to explore the new method of sepsis.The diagnosis of sepsis pathogenesis,treatment principles and common virus infection induced sepsis are reviewed in this paper.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Hepatitis B ; complications ; drug therapy ; Humans ; Liver Cirrhosis ; drug therapy ; etiology ; Medicine, Chinese Traditional ; Phytotherapy

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; therapy ; Humans ; Medicine, Chinese Traditional ; Phytotherapy

Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; drug therapy ; Humans ; Phytotherapy ; methods ; trends

Hypoxic-ischaemic brain injury is a main cause to neonatal death and children neural handicap,and therapeutic efficacy is bad for the completely injured nerve cells.The development research of mesenchymal cells transplantation has a good prospect to treat this disease.

Mycoplasma pneumonia is the smallest free-living and self-replicating prokaryotic microbe being devoid of cell wall, which can not only lead to respiratory system diseases in human, but also play an important role in a wide variety of extrapulmonary diseases, involving cardiovascular, neurological, digestive, skin, hematological systems, and so on.However, the pathomechanisms of mycoplasma pneumonia-related extra-pulmonary diseases(MpEPDs) remain largely unknown.Yet there are three main possible pathomechanisms of mycoplasma pneumonia causing MpEPDs: direct type, immune type and vascular occlusion.They are connected with each other and cooperate on promoting MpEPDs, especially in children and the young.Comprehensive therapeutic strategies cover microbiology, immunology and anticoagulants, while supportive treatments are necessary.Most patients recover from MpEPDs have a favorable prognosis.

Aim To investigate whether Sal B alleviates hypoxic-induced cardiomyocyte injury by regulating the priming of NLRP3 inflammasomes. Methods The effects of Sal B on growth of H9C2 cells were examined by CCK8 assay,then the appropriate concen tration of Sal B was selected. The expression level of LDH was detected by Microliter assay. The expression levels of cTn/IL-lp were measured by Elisa assay. The protein and mRNA levels of TLR4/Myd88/I-RAK1/NF-kB/NLRP3 were detected by Western blot and qPCR. Results Hypoxia intervention notably reduced the viability of H9C2 cells and increased the expression levels of cTn/IL-IP. Besides,the protein and mRNA expression levels of TLR4/Myd88/IRAK1/NF-kB/NLRP3 were significant uP-regulated after hypoxia intervention. However, the viability of H9C2 cells increased, the secretion levels of LDH/cTn/IL-1 p were reduced,and the protein and mRNA levels of TLR4/Myd88/IRAK1/NF-KB/NLRP3 were significant inhibited after pretreated with Sal B. Conclusion Sal B attenuates cardiomyocyte injury by regulating the priming of NLRP3 inflammasome.I.

Tonsillectomy and(or) adenoidectomy are effective procedures for children with chronic tonsillitis, diseases associated with the tonsil and other adenotonsillar diseases, and obstructive sleep apnea-hypopnea syndrome. Since the tonsil and adenoid gland play a dual role in fluid and cell immunity, whether adenotonsillectomy results in the abnormal immune function in children after the surgery has always been the focus of attention. This review focuses on the alterations and impacts on immunity in children after tonsillectomy and/or adenoidectomy. Recent studies confirmed that in short term the immune index may be slightly reduced after the tonsil and adenoid resection in children, however, the decline has no clinical significance because the remaining mucosa-associated lymphoid tissue can compensate for removal of the tonsils and adenoids. Over time, the immune index tends to be normal. The children's postoperative short-term decline in the immune index will gradually recover to the preoperative level or there is no significant difference compared with that in normal children. Therefore, long-term immune function did not decline after tonsil and adenoid resection in children.
Adenoidectomy ; Adenoids ; surgery ; Child ; Humans ; Immunity, Cellular ; Palatine Tonsil ; surgery ; Postoperative Period ; Tonsillectomy ; Tonsillitis ; surgery

Objective As the diagnosis criteria of sepsis,the systemic inflammatory response syndrome(SIRS) has the predictive effect on severe infection.Groups abroad have reported that SIRS criteria is not suitable for the severe infection in emergency room.This article aimed at discussing whether the SIRS criteria and C-reactive protein(CRP) are suitable for the prediction of severe infection in our country.Methods We collected the patients in fever(T>37.5℃)arriving at Shengjing Hospital of China Medical University from October to December in 2015 and recorded the symptoms,signs and treatments,then we discussed the sensitivity and specificity of SIRS criteria in evaluating the severe inflammation.Results Three hundred and ninty-two patients met the SIRS criteria out of 784 patients involved,and 9 of them were in hospital,SIRS criteria had no relevance with the treatments(χ2=4.714,P=0.194),which showed that the SIRS criteria had low sensitivity and specificity in evaluating the severe infection.Taking CRP>8mg/L as unusual,363 patients had abnormal CRP,216 of them met the SIRS and 9 of them were in hospstal.CRP had relevance with the treatment of patients in fever(χ2=46.750,P<0.01),and SIRS combined with CRP had statistics meaning in choosing treatment of infectious patients(χ2=41.783,P<0.01).Conclusion SIRS may fail to diagnose the severe infection.But SIRS criteria combined with CRP has the predictitive effect on infection in pediatric emergency room to a certain extent.