In the construction of closely integrated county medical consortia,the leading role of Party building is crucial for resolving the problem of resource integration and enhancing service efficiency.In response to the current issue of insufficient integration of Party building in medical consortia,the Jiangyin Hospital of Traditional Chinese Medicine Medical Group has taken the"Dandelion+"Party building brand as a carrier and focused on organizational construction,thematic education,integration of Party building and business,and medical services as key measures to explore a path for the deep integration of"Party building+medical consortia".This has led to mutual improvement in brand building,professional skills,resource utilization,service capa-bilities,and overall strength between the leading unit and member units,providing a reference for the long-term development of medical consortia and offering a model for enhancing the effectiveness of Party building in public hospitals.

Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) may affect multiple organ systems, with approximately 50% of IBD patients presenting with at least one EIM during the course of their disease, with cutaneous involvement being particularly common. Cutaneous manifestations can present in various forms. This paper reports a case of ulcerative colitis (UC) complicated with bullous pemphigoid (BP), aiming to enhance clinicians' awareness of skin lesions associated with UC.

Objective To observe the correlations of metabolite levels in medial prefrontal cortex(mPFC)and cancer-related depression(CRD)in patients with non-small cell lung cancer(NSCLC).Methods Totally 38 NSCLC patients were prospectively enrolled and divided into CRD group(n=23)and non CRD group(n=15)based on Hamilton depression scale(HAMD-17).Meanwhile,22 healthy individuals were taken as control group.1 H-MR spectroscopy was performed using Meshcher-Garwood point resolved spectroscopy sequence,then metabolite levels of mPFC were measured,and their correlations with HAMD-17 score were analyzed.Results Significant differences of gamma-aminobutyric acid(GABA)+/Water and glutamate/glutamine complex(Glx)/Water in mPFC were found among 3 groups.GABA+/Water in mPFC of CRD group was significantly lower than that of the other 2 groups(both P＜0.05),and Glx/Water in mPFC of CRD group was significantly lower than that of control group(P=0.034).In NSCLC patients,GABA+/Water in mPFC was negatively correlated with HAMD-17 score(r=-0.491,P=0.002).Conclusion GABA+/Water in mPFC was negatively correlated with HAMD-17 score in NSCLC patients.

Microplastics(particles<5 μm in diameter),generated through plastic processing or natural degradation,have emerged as novel environmental contaminants with increasing threats to ecosys-tems and human health.Recent studies have demonstrated the accumulation of microplastics in various environmental matrices,human tissues and even placentas,highlighting the urgent need to investigate their health effects.These particles enter the human system primarily through dietary intake and water consumption,yet critical knowledge gaps remain regarding their bioaccumulation potential,toxicological profiles,and synergistic interactions with co-existing environmental contaminants.The Drosophila mela-nogaster(fruit fly),a well-established model organism,offers distinct advantages for contaminant toxicity assessment,including a compact life cycle,small body size,rapid reproduction,ease of laboratory maintenance,and extensive availability of transgenic strains.In particular,its genome has a high degree of homology with the human genome,which further enhances its scientific relevance for toxicological studies.In this review,we summarize the advantages of Drosophila models in microplastic toxicity studies,with particular emphasis on recent advances in understanding intestinal toxicity,neuro toxicity,genotox-icity,reproductive toxicity,developmental toxicity,and transgenerational toxicity.We point to critical research gaps that require urgent investigation,including the bioaccumulation dynamics of microplas-tics,metabolic transformation and elimination pathways,multi-pollutant interaction effects,molecular mechanisms of toxicity,and comprehensive health risk assessment frameworks.The review aims to provide data for elucidating the mechanisms of microplastic toxicity and formulating evidence-based prevention strategies.

Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) may affect multiple organ systems, with approximately 50% of IBD patients presenting with at least one EIM during the course of their disease, with cutaneous involvement being particularly common. Cutaneous manifestations can present in various forms. This paper reports a case of ulcerative colitis (UC) complicated with bullous pemphigoid (BP), aiming to enhance clinicians' awareness of skin lesions associated with UC.

Microplastics(particles<5 μm in diameter),generated through plastic processing or natural degradation,have emerged as novel environmental contaminants with increasing threats to ecosys-tems and human health.Recent studies have demonstrated the accumulation of microplastics in various environmental matrices,human tissues and even placentas,highlighting the urgent need to investigate their health effects.These particles enter the human system primarily through dietary intake and water consumption,yet critical knowledge gaps remain regarding their bioaccumulation potential,toxicological profiles,and synergistic interactions with co-existing environmental contaminants.The Drosophila mela-nogaster(fruit fly),a well-established model organism,offers distinct advantages for contaminant toxicity assessment,including a compact life cycle,small body size,rapid reproduction,ease of laboratory maintenance,and extensive availability of transgenic strains.In particular,its genome has a high degree of homology with the human genome,which further enhances its scientific relevance for toxicological studies.In this review,we summarize the advantages of Drosophila models in microplastic toxicity studies,with particular emphasis on recent advances in understanding intestinal toxicity,neuro toxicity,genotox-icity,reproductive toxicity,developmental toxicity,and transgenerational toxicity.We point to critical research gaps that require urgent investigation,including the bioaccumulation dynamics of microplas-tics,metabolic transformation and elimination pathways,multi-pollutant interaction effects,molecular mechanisms of toxicity,and comprehensive health risk assessment frameworks.The review aims to provide data for elucidating the mechanisms of microplastic toxicity and formulating evidence-based prevention strategies.

Objective To explore the value of spectral CT quantitative parameters combined with clinical and CT features for predicting lymphovascular invasion(LVI)of colorectal cancer.Methods Clinical,pathological and preoperative abdominal spectral CT data of 98 colorectal cancer patients were retrospectively analyzed.According to pathological results,the patients were divided into LVI group(n=36)and non-LVI group(n=62).Univariate and multivariate logistic regression were used to compared clinical,pathological,conventional CT manifestations and spectral CT quantitative parameters between groups to screen independent predictors for LVI of colorectal cancer,and then a regression model was constructed.Receiver operating characteristic(ROC)curves were drawn,and the area under the curves(AUC)were calculated to evaluate the predictive efficacy of each single independent predictor and regression model for predicting LVI of colorectal cancer.Results Serum carbohydrate antigen 724,CT showed periintestinal fat infiltration and effective atomic number(Zeff)at venous phase were all independent predictors of LVI of colorectal cancer(OR=4.723,7.301 and 18.912,all P＜0.05).AUC of the above independent predictors was 0.582,0.723 and 0.691,respectively,while of the regression model was 0.837.Conclusion Spectral CT quantitative parameters combined with clinical and CT features could effectively predict LVI of colorectal cancer.

Objective To observe the correlations of metabolite levels in medial prefrontal cortex(mPFC)and cancer-related depression(CRD)in patients with non-small cell lung cancer(NSCLC).Methods Totally 38 NSCLC patients were prospectively enrolled and divided into CRD group(n=23)and non CRD group(n=15)based on Hamilton depression scale(HAMD-17).Meanwhile,22 healthy individuals were taken as control group.1 H-MR spectroscopy was performed using Meshcher-Garwood point resolved spectroscopy sequence,then metabolite levels of mPFC were measured,and their correlations with HAMD-17 score were analyzed.Results Significant differences of gamma-aminobutyric acid(GABA)+/Water and glutamate/glutamine complex(Glx)/Water in mPFC were found among 3 groups.GABA+/Water in mPFC of CRD group was significantly lower than that of the other 2 groups(both P＜0.05),and Glx/Water in mPFC of CRD group was significantly lower than that of control group(P=0.034).In NSCLC patients,GABA+/Water in mPFC was negatively correlated with HAMD-17 score(r=-0.491,P=0.002).Conclusion GABA+/Water in mPFC was negatively correlated with HAMD-17 score in NSCLC patients.

Objective To explore the value of spectral CT quantitative parameters combined with clinical and CT features for predicting lymphovascular invasion(LVI)of colorectal cancer.Methods Clinical,pathological and preoperative abdominal spectral CT data of 98 colorectal cancer patients were retrospectively analyzed.According to pathological results,the patients were divided into LVI group(n=36)and non-LVI group(n=62).Univariate and multivariate logistic regression were used to compared clinical,pathological,conventional CT manifestations and spectral CT quantitative parameters between groups to screen independent predictors for LVI of colorectal cancer,and then a regression model was constructed.Receiver operating characteristic(ROC)curves were drawn,and the area under the curves(AUC)were calculated to evaluate the predictive efficacy of each single independent predictor and regression model for predicting LVI of colorectal cancer.Results Serum carbohydrate antigen 724,CT showed periintestinal fat infiltration and effective atomic number(Zeff)at venous phase were all independent predictors of LVI of colorectal cancer(OR=4.723,7.301 and 18.912,all P＜0.05).AUC of the above independent predictors was 0.582,0.723 and 0.691,respectively,while of the regression model was 0.837.Conclusion Spectral CT quantitative parameters combined with clinical and CT features could effectively predict LVI of colorectal cancer.

In the construction of closely integrated county medical consortia,the leading role of Party building is crucial for resolving the problem of resource integration and enhancing service efficiency.In response to the current issue of insufficient integration of Party building in medical consortia,the Jiangyin Hospital of Traditional Chinese Medicine Medical Group has taken the"Dandelion+"Party building brand as a carrier and focused on organizational construction,thematic education,integration of Party building and business,and medical services as key measures to explore a path for the deep integration of"Party building+medical consortia".This has led to mutual improvement in brand building,professional skills,resource utilization,service capa-bilities,and overall strength between the leading unit and member units,providing a reference for the long-term development of medical consortia and offering a model for enhancing the effectiveness of Party building in public hospitals.