Based on insoluble phenomenon in trace metal powder in TCM granules produced by small and medium-sized pharmaceutical companies, this article discussed the causes and countermeasure from the aspects of formulation composition, preparation technology, and TCM pretreatment, with a purpose to provide the basis for strengthening the quality standard of TCM granules.

Objective To observe the clinical effects of Naloxone and Methylprednisolone(MPS) on therapy of severe bronchiolitis. Methods 98 cases of severe bronchihtis were randomly divided into 2 groups,the Naloxone/MPS treating group and the control group,the later only give regular treatment. Results The Naloxone/MPS treating group scored significantly lower at the time of 48 hours and 5 days(P＜0.001),according to cough,dyspnia and other respiratory symptoms,and the efficacy of Naloxone/MPS treatment is appreciately higher than control(P＜0.01). Conclusion Naloxone and MPS therapy shows remarkable clinical beneficial effects on severe bronchiolitis.

From the point of view of systems science, human body can be considered as a complex system, and the human health system is a subsystem of it. Systems science conducts investigation in a holistic manner. As a theoretical method, it deals with the operation and evolution of systems from the macroscopic perspective, so this theory is similar to phenomenological theory of traditional Chinese medicine (TCM) in methodology. Naturally, numerous theories of systems science can be used in research of the human health systems of TCM. In this paper, the authors introduced synergetics, a theory of modern systems science, and its slaving principle, and in particular, analyzed the concept of order parameters related to the slaving principle and the relationship between body constitutions of TCM and order parameters. The body constitution of TCM can be treated as a slow variable in the human health systems. By using synergetics, the authors established a model of the human health system based on body constitutions of TCM. As an application of the model, the authors illustrated the argumentations in the theory of constitution being separable, the theory of a relationship between constitution and disease, and the theory of a recuperable constitution. To some extent, this work has made links between the TCM theory of body constitution and modern systems science, and it will offer a new thought for modeling the human health system.

Objective To optimize the extracting condition of total isoflavones from Fructus Sophorae by subcritical water extraction.Methods Taking isoflavones yield as index and genistin as control,the technology parameter of subcritical water extraction of Fructus Sophorae isoflavones was optimized by single factor and orthogonal experiment.Results The yield of Fructus Sophorae total isoflavones in the extracts was 23.3% at 130 ℃ for 45 min with the liquid-solid ratio of 12.5 mL/g.Conclusion Compared with traditional extracting methods,subcritical water extraction is a new developing technology in recent years.Its advantage is fast,good-selective.

Objective To explore the factors affecting the quality of life in patients with Parkinson's disease(PD).Methods The quality of life,severity of disease,activities of daily living,motor responses,mental state and the complications of treatment in 71 patients with PD were evaluated by the PD Quality of Life Questionnaire(PDQL),Unified PD Rating Scale(UPDRS),the Hoehn-Yahr scale,the Schwab and England disability scale,the Hamilton Depression Rating Scale for Depression(HRSD),and meanwhile factors such as age,gender,age of onset,the beginning symptom,the location of onset,smoking,doses of L-dopa and fluctuations etc were evaluated by some methods.Results Bivariate analysis showed that the longer course of disease and treatment,the more doses of L-dopa,the higher scores of UPDRS and the Hoehn-Yahr scale,and depression fluctuations with patients,the worse quality of life they had(P

Objective To investigate the effectiveness of choledochoscopy and duodenoscopy in the treatment of residual calculus of the intrahepatic bile duct. Methods Clinical data of 573 cases of choledochoscopy and 36 cases of duodenoscopy from February 1985 to June 2004 were analyzed. Results Stones were completely removed under choledochoscope by way of T-tube sinus tract in 96.02% of patients (507/528) and by way of subcutaneous blind loop in 84.62% of patients (22/26). Percutaneous transhepatic choledochoscope placement was successfully conducted in 84.21% of patients (16/19) and stones were completely removed in 78.95% of the patients (15/19). The success rate of duodenoscopic cholangiography was 91.67% (33/36) and stones were completely removed under duodenoscope in 80.56% of patients (29/36). Conclusions Treatment of residual and recurrent calculus of the intrahepatic bile duct by choledochoscopy and duodenoscopy is effective and convenient.

Objective To investigate the influence of aging on motor function,binding activity and protein expression level of striatum dopamine transporter(DAT)of rats. Methods Rolling-bar test was performed to assess motor function.Western blot and 131I-FP-β-CIT up-take ratio were used to evaluate DAT protein 1evel and striatum DAT binding activity respectively. Results There were an age-related decline of rolling-bar latency and striatum 131I-FP-β-CIT up-take ratio in rats older than6 months.There was a significant difference between 6-month-old rats and older rats(12-month-old rats,16-month-old rats,20-month-old rats),and rolling-bar latency was correlated with striatum 131I-FP-β-CIT up-take ratio(r=0.656,P＜0.01).There was no change in DAT protein 1evel during aging process. Conclusions The age-related decline of motor function of rats was correlated with the decreasing of striatum DAT binding activity.The synaptic membrane expression of striatum DAT may decrease in aged rats.

Objective To explore the biomechanis with different bone density by the pedicle screws fixation before and after fatigue test.Thus provide biomechanical basis for the clinical work.Methods A total of 27 fresh lumbar vertebrae samples of adult sheep (L1-L5) were equally divided into three groups,such as group A of decalcified with HCL 0 h,group B of decalcified with HCL 2 h and group C of decalcified with HCL 4 h,by using the random number table method,every groups was 9 models.Four screws was performed on the L4-L5 pedicle of vertebral arch of the three groups.Three groups were performed fatigue test of 250 000 times in 4 direction (flexion,extension,left lateral bending,right lateral bending) by (300+ 105) N load.The range of motion(ROM),the axial compressive stiffness were measured and the results in every group were compared before and after fatigue test.Results After fatigue test,ROM and the axial compressive stiffness had no significant change in group A (P＞0.05),but ROM of B group and C group were both increased and the axial compressive stiffness were decreased,Significance was found with and between groups.Conclusion The stability of people who are performed pedicle screws simplly may be decrease when the spine of osteopenia.

Objective To evaluate multichannel functional electrical stimulation (FES) on motor and balance function of lower limbs in adolescent with cerebral palsy. Methods From January, 2014 to June, 2015, 20 adolescents with cerebral palsy were randomly divided into FES group (n=10) and control group (n=10). Both groups received routine exercise therapy. FES group received active and passive FES treadmill based on normal walking pattern. The Fugl-Meyer Assessment (FMA) was used to evaluate the motor function of lower limbs;the Berg Balance Scale (BBS) was used to assess the balance function, and the Gross Motor Function Measure (GMFM) was used to test the gross motor function. Results The scores of FMA, BBS and GMFM significantly improved 30 days after treatment (F>223.749, P<0.001), and the scores were higher in the FES group than in the control group (t>2.706, P<0.05). Conclusion FES treatment can improve the motor and the balance function of lower limbs in adolescents with cerebral palsy.

Objective To determine the influence of depression on C reactive protein in patients with chronic ischemic heart failure (CIHF).Methods 73 patients with CIHF were divided into CIHF without depression group(n=49) and CIHF with depression group (n=24) according to the standard sore of the self-rating depression scale.C reactive protein(CRP)and other clinical characteristics were detected.The geometric means of CRP between two groups were compared,and stepwise multiple linear regression analysis was used to confirm the independent correlation factors of CRP.Results (1) The geometric means of CRP in CIHF without depression group and CIHF with depression group were (1.38± 1.29)mg/L and (1.78±1.53) mg/L respectively.No statistically significant difference was found between two groups(P=0.276).(2) Stepwise multiple linear regression analysis showed that aspirin inversely related with CRP(β=-1.070,P=0.004),but brain natriuretic peptide (BNP)positively related with CRP(β=0.426,P=0.001).Conclusion Depression has no additional effect on CRP in patients with CIHF.