1.Development of Blood Flow and Oxygen Monitoring System for Mice Based on Laser Speckle and Spectrum.
Yuemei ZHAO ; Yanbai XUE ; Yan ZHANG ; Weitao LI ; Zhiy QIAN
Chinese Journal of Medical Instrumentation 2019;43(1):1-4
simultaneous monitoring of blood flow and changes of concentration of oxyhemoglobin (ΔHbO) in brain is a key important method for the research of cerebrovascular disease. In this study, a new monitoring system, combining laser speckle contrast imaging method and spectral analysis method, was proposed, which could be utilized to measure the cerebral blood flow and ΔHbO on mice during traumatic brain injury. The principle of the present system was studied and the hardware platform of the detection system was built. Then, user interface software and algorithms were implemented based on Labview and Matlab software. Finally, the performance of the present system was verified by the experiments.
Algorithms
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Animals
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Blood Gas Analysis
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instrumentation
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Brain
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Cerebrovascular Circulation
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Lasers
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Mice
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Oxygen
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analysis
2.Development of Diffuse Reflectance Spectroscopy Detection and Analysis System for Cervical Cancer.
Yanbai XUE ; Yuemei ZHAO ; Liuye YAO ; Weitao LI ; Zhiyu QIAN
Chinese Journal of Medical Instrumentation 2019;43(3):157-161
Cervical cancer is a common female malignant tumor. It has been increasing and rejuvenating in recent years. Early screening of cervical cancer is an effective control method to block cancer. In this study, a diffuse reflectance spectrum detection and analysis system based on LabWindows development software and MariaDB database was developed, which can acquire and save the spectral data to the database. The method of a neural network model based on spectral database was built to distinguish the cervical tissue and the normal tissue. The nude mouse tumor model test and human volunteer test were performed respectively, which verified that the system can distinguish between normal tissue and tumor tissue, and can be applied to the screening of cervical precancerous lesions.
Animals
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Female
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Humans
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Mice
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Mice, Nude
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Neural Networks (Computer)
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Spectrum Analysis
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Uterine Cervical Neoplasms
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diagnostic imaging