1.Clinical analysis of 21 patients with secondary epilepsy after stroke
Chinese Journal of Primary Medicine and Pharmacy 2010;17(15):2065-2066
Objective To explore the relationship between epilepsy and stroke,the features of secondary epilepsy and its treatment. Methods 233 stroke patients were observed and the clinical data of 21 patients who had secondary epilepsy were analyzed. Results Secondary epilepsy after stroke was mainly seen in the cortical stoke patients, the incidence of epilepsy of the cortical stroke group was 16.7% , which was significantly higher than that of the gubcortical stroke patients(5.7% ) ,and there was significant difference between the two groups. The incidence of epilepsy of stroke with a lesion >4cm group was 17. 3% .which was significantly higher than that of stroke with a lesion <4cm group(5.4% ), there was also significant difference between the two groups. There was no significant difference between ischeraic stroke and hemorrhagic stroke(P>0.05). Conclusion The incidence of secondary epilepsy after stroke had no correlations with the stroke types,but was related to the area and the location of the stroke.
3.Time-frequency analysis of ECG signals
Zhen LEI ; Yiping CHEN ; Yan TANG
Chinese Medical Equipment Journal 2004;0(08):-
In this paper,a time-frequency approach is used for the recognition and analysis of ECG signals for a normal or an abnormal patient.An iterative deconvolution procedure is applied to calculate the time-frequency representations.This method can enhance the resolutions of the signals.
4.Study on the beneficial effect of dual peroxisome proliferator-activated receptor agonist WY14643 on vascular endothelium
Chen QU ; Liang TANG ; Yan ZHU
Journal of Chinese Physician 2012;14(6):746-749
ObjectiveThe present study aimed to determine whether or not dual paroxysm proliferator-activated receptor (PPAR) agonist,WY14643,improved the dysfunctioned vascular endothelium in hypertension by reducing endothelium-derived contracting factors ( EDCFs ),and to explore the molecular mechanism it was involved in.MethodsIsometric tension in isolated thoracic aortic rings of spontaneously hypertensive rats was recorded.Endothelium-dependent contractions evoked by acetylcholine in the presence of L NAME were reduced by fenofibrate.Cyclooxygenase 1 ( COX1 ) activities were determined by analyzing the peroxidase activity of cyclooxygenase colorimetrically by using ELISA kit.ResultsCompared to the control group,WY14643 significantly decreased the vasoconstriction in aorta of the SHR rats(P=0.014).PPARα antagonist MK866 enhanced the vascular contractility of SHR rats that were incubated with 10.0μmol/L WY14643( P=0.021 ).PPARΥ antagonist GW9662 did not significantly affect the vascular contractility of SHR rats that were incubated with 10.0 μmol/L WY14643( P=0.061 ).The levels of serum PGFlα(P=0.012),2α( P =0.019) and TXB2(P=0.023) in SHR rats incubated with 10.0 μmol/L WY14643 were significantly lower than the control group,respectively.Under the condition of the existence of vascular endothelium,the expression of COX-1 in SHR rats incubated with WY14643 was significantly lower than that in SHR rats incubated without WY14643 (P=0.017).ConclusionsThose data showed that WY14643 reduced the release of EDCFs,it suggests that WY14643 protects against vascular diseases through the PPAR activators in spontaneous hypertension.
5.Efficacy and Safety of Sodium Valproate versus Diazepam in the Treatment of Status Epilepticus in Adults:a Meta-analysis
Chen LIU ; Suying YAN ; Jing TANG
China Pharmacy 2015;(24):3368-3370
OBJECTIVE:To systematically evaluate the efficacy and safety of sodium valproate versus diazepam in the treat-ment of status epilepticus in adults,and to provide evidence-based reference for clinic treatment. METHODS:Retrieved from Med-line,EMBase,PubMed,Cochrane Library,CJFD,VIP datebase,CBM and Wanfang database,the randomized controlled trials (RCT) about sodium valproate (test group) versus diazepam (control group) in the treatment of status epilepticus in adults were collected. Meta-analysis was performed by using Rev Man 5.0 statistical software after extracting data and evaluating quality. RE-SULTS:A total of 5 RCTs were included,involving 276 patients. Results of Meta-analysis showed that recurrence rate of epilepsy in 48 h in test group was significantly lower than that of control group [OR=0.39,95%CI(0.16,0.96),P=0.04]. Compared with the control group,the effective rate controlling epilepsy within 2 h[OR=1.76,95%CI(0.88,3.52),P=0.11] and incidence of liver injury[RR=1.19,95%CI(0.38,3.70),P=0.77] were no significant differences. CONCLUSIONS:The efficacy and safety of sodi-um valproate was equivalent to diazepam in the treatment of status epilepticus in adults,however,sodium valproate was superior to diazepam in terms of controlling recurrent effect. Due to methodology limit of included studies,large-scale and high quality RCT are required for further validation of the conclusions.
6.Prevention and Control of Methicillin-resistant Staphylococcus aureus Infection in ICU
Hongyan CHEN ; Yufen TANG ; Yan SUN
Chinese Journal of Nosocomiology 2009;0(21):-
OBJECTIVE To investigate and analyze the cause of the cross infection of Methicillin-resistant Staphylococcus aureus(MRSA) in ICU patients,and to apporach its preventive and control measures.METHODS Eiological inspection and sanitary monitoring have been done in ICU where there were two MRSA patients from June 6th,2008 to August 1st,2008.RESULTS MRSA has been detected on the hands of the ICU medical staff,on the bed-desks,on the switches of the vacuum extractor and gas supply unit on the wall,and in the NS for inhaling sputum.The separation rate were 37.5%,20.0%,54.5%,37.5%,87.5%.CONCLUSIONS ICU patients are prone to be infected with MRSA,which has a strong drug resistance and the infection is difficult to be treated.The cross infection can be prevented and controlled by rational administration,sterile operation and insulation.
7.Vascular necrosis of femoral head in childhood lymphocytic malignant tumor.
Jing-yan TANG ; Hui-liang XUE ; Jing CHEN
Chinese Journal of Pediatrics 2005;43(12):937-938
Adolescent
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Blood Vessels
;
pathology
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Female
;
Femur Head
;
blood supply
;
pathology
;
Femur Head Necrosis
;
pathology
;
Humans
;
Male
8.Promote multidisciplinary study on anthracycline-induced cardiotoxicity in children.
Shu-bao CHEN ; Mei-rong HUANG ; Jing-yan TANG
Chinese Journal of Pediatrics 2013;51(8):565-568
Anthracyclines
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administration & dosage
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adverse effects
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Antineoplastic Agents
;
administration & dosage
;
adverse effects
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Biomarkers
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blood
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Cardiomyopathies
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chemically induced
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diagnosis
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prevention & control
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Cardiotonic Agents
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therapeutic use
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Child
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Child, Preschool
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Echocardiography
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Heart
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drug effects
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Heart Diseases
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chemically induced
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diagnosis
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prevention & control
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Humans
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Risk Factors
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Survival Analysis
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Troponin I
;
analysis
9.Expression level of endogenetic nitric oxide on reproduction of human anterior cruciate ligament cells
Weiguo LIANG ; Yan SHEN ; Honghui CHEN ; Yi TANG ; Cancan ZHONG
Chinese Journal of Orthopaedic Trauma 2004;0(08):-
Objective To investigate the expression level of endogenetic nitric oxide(NO) in the reproduction process of human anterior cruciate ligament cells. Methods Anterior cruciate ligament cells were isolated and subcultured from the human anterior cruciate ligament. LPS was used to induce the anterior cruciate ligament cell to express the inducible nitric oxide synthase(iNOS ), and N-monomethyl -L-Arginine (L-NMMA) was used as the interdiction of nitric oxide. They were alone or together added in the culture medium of anterior cruciate ligament cells in different groups. The level of NO was indirectly measured in the medium of HACL. Results LPS promoted significantly anterior cruciate ligament cells to produce endogenetic nitric oxide, compared with the control group(P
10.Study of blenderized diet on nutritional status in old patients
Guizhen XIAO ; Guiping MEI ; Yinlian TANG ; Yan CHEN ; Yanhua JIANG ;
Parenteral & Enteral Nutrition 1997;0(02):-
Objectives:To observe the supporting effect of blenderized diet on the nulritional statusin the old patients. Methods:Twenty four patients were given blenderized diet made in our department as nutrition support.The nutritional assessments were preformed before and after the support. Results:The serum levels of albumin and phosphorus and the total lymphocyte count were increased after the support( P