OBJECTIVE: To develop a method for determination of the content of Dexamethasone acetate in Compound tretinoin ointment by RP-HPLC. METHODS: The separation was performed on C18 column with methanol: water (70∶30) as a mobile phase, wavelength of UV detector at 240nm. RESULTS: The linear range of Dexamethasone acetate was within 0.028 3～0.849 0?g(r=0.999 9). The average recovery of Dexamethasone acetate was 101.13%, with RSD at 1.28%. CONCLUSION: The method is simple, rapid and capable of producing good separation results. It can be applied to the quality control of Compound tretinoin ointment.

OBJECTIVE:To investigate situation and trend of proton pump inhibitors in 19 hospital of Hangzhou area and to provide reference for the research,production,sales and clinical application of this kind of drugs. METHODS:Utilization of proton pump inhibitors in 19 hospital of Hangzhou area during the period of 2004～2008 were analyzed statistically in respect of consumption sum,DDDs and DDC. RESULTS:Both consumption sum and DDDs of proton pump inhibitors increased quickly in recent five years. Amount of oral omeprazole(capsule and tablet)was the greatest among those categories and increased steadily. Amount of rabeprazole and esomeprazole as new type of proton pump inhibitors increased rapidly. CONCLUSION:Proton pump inhibitors have great potential for development. Omeprazole are widely used in the clinic as mature proton pump inhibitors.

Echocardiography, Three-Dimensional ; Heart Defects, Congenital ; diagnostic imaging ; therapy ; Humans

Electron Transport ; Electron Transport Complex III ; deficiency ; Humans ; Mitochondria ; metabolism

Endocrine System Diseases ; diagnosis ; Hearing Disorders ; diagnosis ; Humans ; Infant, Newborn ; Metabolism, Inborn Errors ; diagnosis ; Neonatal Screening ; methods ; standards

Objective To investigate and improve the methods of nasal feeding to reduce the occurrence of complication such as diarrhea and vomiting.Methods We separated 140 patients with heavy craniocerebral injury into the control group (50 patients) and the experimental group (90 patients) according to different nasal feeding methods. For the control group traditional method was used. For the experimental group infusion pump was used to control infusion rate. The incidence of complication was compared between two groups. And within experimental group, the same nutrient solutions in respect of type and volume were infused during 10 hours, 16 hours, and 18 hours respectively. The relationship between infusion rate and the occurrence of complication was observed, analyzed and compared to seek for the most suitable enteral nutrition route which incurred the least complication.Results The incidence of diarrhea and vomiting in the experimental group was lower than that of the control group. And there were no significant differences in the occurrence of complication by using infusion pump at three different infusion rates within the experimental group. Conclusions The application of infusion pump in nasal feeding can reduce the incidence of complication and infusing nutrient solution at a slow rate was not necessary.

Objective To explore the clinical significance of gastric hyperplastic polyp pits under magnifying endoscopy. Methods Summary confirmed by magnifying endoscopy and pathological examination gastric hyperplastic po]yp's performance of magnifying endoscopy,Hp positive and the results of pathology during February 2004 to De-cember 2006. Results 55 patients found 116 gastric polyp,41.4% (48/116) with type A,26.7% (31/116) with type B,19. 8% (23/116) with type C,8. 6% (10/116) with type D,2. 6% (3/116) with type E,one case gastric pits blurred(type F) 0. 9% (1/116). 4 cases with type E and type F found moderate-severe atypical hyperplasia. Conclu-sion Gastric hyperplastic polyp pits with type E and type F ,their results of pathology to display atypical hyperplasia.

0.05)but a statistical difference between groups I and groups III(P