Objective To investigate the status of general self-efficacy and work burnout of nurses in high-ranking officer wards and analyze its correlation.Methods Totals of 100 nurses in high-ranking officer wards were investigated with General Self-efficacy Scale(GSES) and Maslach Job Burnout scale between October 2010 and June 2011.Results The general self-efficacy score of high-ranking officer wards nurses was lower than that of the norm [ (2.63 ± 0.46) vs (2.95 ± 0.53)],and the difference was statistically significant (t=-4.994;P ＜ 0.01). Among the work burnout score of high-ranking officer wards nurses,the individual achievement sense and depersonalization score were lower than that of the sample of Maslach [ (32.48 ± 9.55)vs (36.53 ±7.34),(5.38 ±6.58) vs (7.12 ±5.22) ],and the difference was statistically significant- (t =- 4.239,- 2.646 ;P ＜ 0.01).Correlation analysis showed that general self-efficacy was positively with the individual achievement sense (r =0.409,P ＜ 0.01).Conclusions General self-efficacy of nurses in highranking official wards should be improved.Improving nurses' general self-efficacy can improve their individual achievement sense,on some extent,and can reduce their work burnout.

Objective To study the effects of water decoction and chloroform extraction fraction before and after processing of Aconitum sinomontanum Nakai (ASN) on the analgesic and anti-inflammatoryin mice.Methods Kunming mice were randomly divided into 10 groups (10 mice in each group)according to the weight:blank control group (0.5％ methylcellulose),positive control group (10 mg · kg-1 indomethacin + 1.6 mg · kg-1 lappaconitine),the high and low dose groups of water decoction of raw ASN (0.9,0.3 g · kg-1),the high and low dose groups of water decoction processed product (0.9,0.3 g · kg-1),the high and low dose groups of chloroform extraction fraction of ASN (4.5,1.5 mg · kg-1),the high and low dose groups of chloroform extraction fraction of processed product (4.5,1.5 mg · kg-1).Hot plate was used to study the analgesic effect of water decoction and chloroform extraction fraction before and after processing of ASN.Auricular swelling induced by dimethylbenzene in mice were observed for the evaluation of anti-inflammatory effects of it.Results Analgesic activity:Inthe hot plate test,the pain threshold of high dose groups of water decoction of processed product at 30 minafter the last administration was (24.1 ± 6.3) s,the pain threshold of high dose groups of water decoction of processed product,high and low dose groups of chloroform extraction fraction of raw product,high dose groups of chloroform extraction fraction of processed product at 120 min after the last administration were(49.7 ± 9.7),(49.8 ±7.4),(47.3 ± 6.3),(45.1 ± 7.1)s,compared with blank control group,the difference were significant (all P ＜ 0.05),respectively.Anti-inflammatory activity:The swelling degree of high dose groups of water decoction of raw product,high and low dose groups of water decoction processed product,high and low dose groups of chloroform extraction fraction of raw and processed product were (16.9 ± 11.2),(15.2 ±4.8),(17.7 ±6.4),(14.2 ±4.2),(16.0 ± 4.5),(15.7 ± 5.2),(12.5 ± 5.5) mg,compared with blank control group,the difference were significant (all P ＜0.01).The each groupof processed products compared with the each group of raw product,the difference was not significant (P ＞ 0.05).Conclusion The raw Aconitum sinomontanum Nakai have strong analgesic and anti-inflammatory effects,and processed product still remain strong analgesic and anti-inflammatory effects,and have a trend to increase compared with the raw product.

Cannabinoid receptor type 2( CB2 R),a member of the G protein-coupled receptor( GPCR) superfamily,has a variety of biological activities,such as regulating pain response,resisting inflammation and fibrosis,and mediating bone metabolism. Some CB2 R regulators exhibit a good regulatory effect on bone metabolism. Cannabinoids in Cannabis sativa can cause psychoactive effects despite various pharmacological actions they exerted by targeting CB2 R. Therefore,it is of great significance to discover CB2 R regulators in non-Cannabis plants for finding new lead compounds without psychoactive effects and elucidating the action mechanism of plant drugs. The present study clarifies the discovery,structure,and physiological functions of CB2 R,especially its regulatory effects on bone metabolism,summarized CB2 R regulators extracted from non-Cannabis plants,and systematically analyzes the regulatory effects of CB2 R regulators on bone metabolism in animals,osteoblasts,and osteoclasts,to provide a scientific basis for the discovery of new CB2 R regulators and the development of anti-osteoporotic drugs.
Animals ; Cannabinoids/pharmacology* ; Cannabis ; Osteoblasts ; Osteoclasts ; Receptors, Cannabinoid