1.Value of ultrasonography in diagnosing the occult dorsal carpal ganglion
Chinese Journal of Ultrasonography 2008;17(7):621-623
Objective To evaluate the value of uhrasonography in diagnosing the occult dorsal carpal ganglion. Methods Sixteen patients with chronic dorsal wrist pain received ultrasound examination. Eleven ofthem were treated with surgical therapy. And they were followed up for 1-8 months. Results The ultrasound characteristics of oecuh dorsal carpal ganglion were depicted as follows;①The dorsal cortical bone of scaphoid and lunate was continued and without damage. ② An oval anecho lesion with clear boundany, smooth ganglion wall, lateral shandowing and posterior enhancement could be detected in the dorsal part of scapholunate joint. ③Color Doppler flow imaging showed there was not obvious blood flow signals inside and around the ganglion. Conclusions Uhrasonography could be acted as a routine examination technique after the X-ray examintion in the diagnosis of the the occult dorsal carpal ganglion.
2.Expression of mismatch repair genes hMLH1 and hMSH2 and their significance in patients with colorectal carcinoma
Chinese Journal of Clinical Oncology 2013;(12):710-713
10.3969/j.issn.1000-8179.2013.12.007
3.Study on the relationship between echocardiographic epicardial fat thickness and the severity of coronary heart disease
Chinese Journal of Primary Medicine and Pharmacy 2013;20(18):2752-2754
Objective To investigate the correlation between epicardial fat thickness (EAT) and the risk factors of coronary artery disease (CAD) as well as the severity of coronary lesions with echocardiography,Methods According to the results of coronary angiography,80 patients underwent coronary angiography were divided into coronary heart disease group (CHD group,4 6 cases) and without coronary heart disease group (control group,34cases),and according to coronary artorrythe severity,CHD goup was divided into subgroups of single-vessel disease (24 cases) and multivessel disease subgroup(22 cases).Tho epioardial fat thickness on the free wall of the right ventricle was measured at end-systole from the para-sterna,long-axis vlews.The relationship between EAT and the risk factors of CAD (such as age,gender,hypercholesterolemia,hypertenston,diabetes,smoking,family CAD history) as well as the severity of coronary lesions were analyzed.Results EAT in multivessel disease CAD group [(8.85 ± 1.44)mm] was significantly higher than that in single vessel CAD group[(6.86 ± 1.09) mm] and control group [(4.58 ± 1.12) mm] (all P < 0.01).EAT was significantly related with the risk factors of CAD.Although the risk factors of CAD such as age,blood glucose,blood pressure were adjusted,EAT was still independently associated with CAD (OR:5.394,95 % CI:1.700 ~ 17.1 12,P =0.004).Concluslon The level of EAT is significantly correlated with CAD and the severity of coronary lesions.
4.Significance of detecting level of CRP,TNF-α,IL-6 and IGF-1 in patients with type 2 diabetes mellitus
International Journal of Laboratory Medicine 2017;38(3):344-346
Objective To investigate the significance of detecting the level of CRP,TNF-α,IL-6 and IGF-1 in the patients with type 2 diabetes mellitus(T2DM).Methods Sixty patients with T2DM in the Pingliang Municipal People′s Hospital from February 2013 to March 2015 were selected as the observation group And contemporaneous 60 individuals undergoing healthy physical exami-nation were selected as the control group.The levels of FBG,2 hBG,FINS,HbA1c,CRP,TNF-α,IL-6 and IGF-1 were detected in these two groups.The correlation between CRP,TNF-α,IL-6 and IGF-1 with FBG,FINS and HbA1c were analyzed.Results The levels of FBG,2 hBG and HbA1c in the observation group were significantly higher than those in the control group,the difference was statistically significant (P<0.05).The FINS level in the observation group was significantly lower than that in the control group,the difference has statistically significant (P<0.05).The levels of CRP,TNF-α,IL-6 and IGF-1 in the observation group were (8.46±2.45)mg/L,(18.56±4.23)ng/L,(13.53±3.24)pg/L and (125.33±23.14)ng/L respectively,which were signifi-cantly higher than (3.23±1.02)mg/L,(11.25±3.01)ng/L,(7.24±1.78)pg/L and (98.45±18.56)ng/L in the control group, the difference was statistically significant(P<0.05).CRP,TNF-αand IL-6 were positively correlated with FBG,FINS and HbA1c;IGF-1 was negatively correlated with FBG and HbA1c.Conclusion Detecting the CRP,TNF-α,IL-6 and IGF-1 levels can provide a basis for the diagnosis of T2DM and thinking for its treatment.
5.Effect of total paracentesis on portal hemodynamics in liver cirrhosis
Yan CHEN ; Yabei CHEN ; Rongfang TAO
Chinese Journal of Practical Internal Medicine 2002;0(08):-
Objective To observe the effects of total paracentesis with normal saline intravenous infusion on portal hemodynamics in refractory ascites of liver cirrhosis.Methods One hundred and forty-two cirrhotic patients with tense ascites were divided into two groups at random.Eighty-seven patients (group A) were treated by total paracentesis with normal saline intravenous infusion beside conventional therapy and diuretics;55 patients (group B) were treated with conventional therapy and diuretics.Results The total effective rate in ascites was 67.8% in group A and 23.6% in group B,P
6.The essential of cerebroprotein hydrolysate injection in the management of epidemic encepha-litis B
Yan CHEN ; Yabei CHEN ; Rongfang TAO
Chinese Journal of Practical Internal Medicine 2006;0(S1):-
Objective To explore the essential of cerebroprotein hydrolysate injection in the manage-ment of epidemic encephalitis B.MethodsTwo hundred and thirty-two patients with epidemic ence-phalitis B were randomly divided into two groups,one hundred and twenty-six patients in treating group,and one hundred and six patients in controlled group.Beside the conventional and symptomatic therapy,the patients in treating group received the management of cerebroprotein hydrolysate injection 10 mL+5% glucose solution 250 mL,iv drip,qd for 5 d and those in controlled group received the management of interferon?1b 1 MIU,sc,qd for 5 d.ResultsThe total clinical effective rates in treating group and controlled group were 94.6% and 82.6% respectively,there were remark-ably differences between two groups(P
7.CT manifestations and pathologic features of mediastinal primary small cell neuroendocrine carcinoma
Tao CHEN ; Jingdong YAN ; Zhenni LEI
Journal of Medical Postgraduates 2015;28(10):1057-1060
Objective Mediastinal primary small cell neuroendocrine carcinoma ( MPSCNC) is a rare neoplasm of high ma-lignant potential mostly affecting elderly and middle-aged males, which has a high rate of misdiagnosis because of its unidentified histo-genesis and lack of obvious characteristic imaging findings .This study was to investigate the CT findings and pathologic features of MP-SCNC, so as to improve the recognition and diagnostic accuracy of the disease . Methods We retrospectively analyzed the imaging and clinicopathologic data about 4 cases of pathologically confirmed MPSCNC and reviewed relevant literature . Results Of the 4 tumors, 2 were located in the anterior-middle-superior mediastinum , 1 in the anterior-superior mediastinum , and the other in the mid-dle-superior mediastinum .Three of them exhibited irregular shape , unclear boundary , and inhomogeneous density , with low-density cyst degeneration and necrosis , of which two had scattered punctate calcifications .Enhanced scanning revealed moderate uneven en-hancement in 3 cases and ring-shaped enhancement the other .Pathological findings showed small tumor cells with marked pleomor-phism, little cytoplasm, pale chromatin, inconspicuous or absent nucleoli , and obvious mitotic figures.Immunochemistry manifested positive CgA, Syn, and CK in all the 4 cases, positive NSE, CD56, and Ki-67 in 3 cases, and positive epithelial membrane antigen in 1. Conclusion A tumor located in the anterior-middle mediastinum with scattered punctate calcifications and compressing or inva-ding the adjacent mediastinal structures should be suspected as a small cell neuroendocrine carcinoma . However , definite diagnosis should be based on histopathologic and immunohistochemical exami-nations .
8.EFFECT OF THREE TYPES OF CHELATING AGENTS ON EXCRETION AND DISTRIBUTION OF MERCURY
Zhengqin TAO ; Zhenjia CHEN ; Xueming YAN
Chinese Pharmacological Bulletin 1987;0(02):-
After the mice had been injected im203HgCl2 185 kBq/mouse, they were injected ip with chelating agents. There were 15 chelating agents of 3 types,of which the effect of eliminate mercury of pyridoxine derivative, benzenesul-fonate cysteine and sodium dimercaptosuccinate ( DMS-Na) were better than the others. The urine excretion of 208Hg was increased and the ratio were 4.6,11.5 and 22 respectively in comparison with the control group.The minimum 203Hg content in organs of mice was in the DMS-Na group,the next was the benzenesulfonate cysteine group,but there no significant difference between these 2groups.
9.MSCT Imaging Findings in Anterior Mediastinal Primary Malignant Tumors
Tao CHEN ; Jingdong YAN ; Zhenni LEI
The Journal of Practical Medicine 2015;(18):3039-3042
Objective To investigate the MSCT imaging of anterior mediastinal primary malignant tumors , and to improve the accuracy of diagnosis. Methods The imaging and clinical data of forty-five patients with anterior mediastinal primary malignant tumors were retrospectively analyzed. Results Among all forty-five cases, there were seventeen thymic carcinomas , and cystic and necrotic earas were seen in all cases. Fourteen were malignant lymphomas with a single irregular soft tissue mass or multiple merged nodules. There were enlarge lymph nodes around the tumors and (or) in other parts of the body. Twelve cases were malignant germinomas, the levels of rinary human chorionic gonadotropin (HCG) or blood armour fetuin (AFP) were abnormal in ten cases, and calcifications were seen in four cases and fat composition was observed in three cases. One malignant solitary fibrous tumor was observed on the left side of the anterior-superior mediastinum with cystic degeneration and necrosis. One was neuroendocrine carcinoma with clear boundary , cystic degeneration and necrosis , after enhanced scanning , it showed ring-shaped reinforcement. Conclusion Anterior mediastinal primary malignant tumors have certain characteristics of MSCT findings , in combination with clinical information , which can help the diagnosis and efficacy evaluation.
10.Effect of Qizhi Weitong Granules combined with rabeprazole on gastroesophageal dynamics and inflammatory factors in reflux esophagitis
Chao CHEN ; Yan JIAO ; Yuan TAO
Drug Evaluation Research 2017;40(1):75-78
Objective To observe the effect ofQizhi Weitong Granules combined with rabeprazole on gastroesophageal dynamics and inflammatory factors in reflux esophagitis (RE) and explore its clinical significance.Methods Nighty-six RE patients from Changping Chinese Medicine Hospital were selected in this study,which randomly divided into control group (n =48) and observation group (n =48).The control group was given rabeprazole 10 mg/time (2 times/d) for 4 weeks.The observation group was given rabeprazole 10 mg/time (2 times/d) and Qizhi Weitong Granule 5 g/time (3 times/d) for 4 weeks.The gastrin and motilin expression was detected by radioimmunity analysis.The IL-17 and IL-23 was detected by ELISA analysis.The rate of clinic effects and adverse reaction was compared.Results There was no significant difference ofgastrin and motilin between the two groups before treatment.After treatment,gastrin and motilin was increased in the two groups (P < 0.05,0.01).However,gastrin and motilin was higher in observation group than that in control group after treatment (P < 0.05).There was no significant difference ofIL-17 and IL-23 between two groups before treatment.After treatment,IL-17 and IL-23 was decreased in the two groups (P < 0.05,0.01).However,IL-17 and IL-23 was lower in observation group than that in control group after treatment (P < 0.05).The rate of clinic effects was 93.8% in observation group,which was better than 81.3% in control group (P < 0.05).The rate of adverse reaction was 10.4% in control group and 8.3% in observation group.There was no significant difference between two groups.Conclusion Qizhi Weitong Granules combined with rabeprazole can improve gastroesophageal dynamics and inhibit inflammatory response in RE patients,with significantly clinical effect and safety.