1.Ultrasonic manifestations of heptic mesenchymal hamartoma in children
Xiao-man, WANG ; Li-qun, JIA ; Yan-xiu, HU
Chinese Journal of Medical Ultrasound (Electronic Edition) 2012;09(6):516-520
Objective To describe the sonographic appearance of mesenchymal hamartoma of the liver(MHL)and to analyze the diagnostic value of ultrasound.Methods Eleven surgically and pathologically confirmed cases of MHL from January 2005 to May 2011 in the Beijing Children′s Hospital were retrospectively reviewed.Results Ultrasound examinations showed 9 cystic hamartomas,including 7 multiseptate cystic and 2 monocystic lesions.Of the 7 multiseptate cystic hamartomas,4 had a honeycomb appearance and 3 had irregularly-distributed multiple cysts with varied septations.Of the 2 monocystic hamartomas,1 had a large cystic portion while the other was mainly solid with approximately 4% cystic portion of the tumor.Two cases in this group were solid,presenting with a well-defined homogenous mass.Conclusions Ultrasonography is an effective imaging modality for the diagnosis for MHL.A mixed or a mainly-cystic liver mass found in a child less than 2 years old should be suspicious for MHL.
2.Observation of therapeutic effects of point application at Shenque (CV 8) plus moxa-salt hot compress for prevention of gastrointestinal adverse reactions after chemotherapy for non-Hodgkin lymphoma
Yan-Fei GUO ; Qun-Ling HU ; Yang-Yang CAI ; Xiao-Wei FU ; Guo-Qi HUANG
Journal of Acupuncture and Tuina Science 2018;16(4):248-252
Objective:To observe the clinical efficacy of point application with Da Huang (Rhizoma Rhei Cruda) powder at Shenque (CV 8) plus moxa-salt hot compress on the umbilicus for preventing gastrointestinal adverse reactions after chemotherapy for non-Hodgkin lymphoma (NHL).Methods:A total of 60 cases with NHL under chemotherapy were divided into two groups by hospitalization order,with 30 cases in each group.The control group was treated with routine nursing and the observation group was additionally given point application with Da Huang (Rhizoma Rhei Cruda) powder plus moxa-salt hot compress on the umbilicus,to compare the effect in preventing gastrointestinal adverse reactions after chemotherapy between the two groups.Results:The occurrence rates of constipation,nausea,vomiting and poor appetite on the second day and fifth day after chemotherapy were obviously lower in the observation group than those in the control group,with statistically significant differences between the two groups (all P<0.05).Conclusion:The point application with Da Huang (Rhizoma Rhei Cruda) powder at Shenque (CV 8) plus maxa-salt hot compress on the umbilicus can produce more significant efficacy in preventing the gastrointestinal adverse reactions after chemotherapy for NHL than routine nursing.Moreover,it is simple and easy to be used and popularized.
3.Functional and histological changes in aging gerbil bladders
yun-xiang, XIAO ; shi-liang, WU ; ji-hong, DUAN ; yan-qun, NA
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(12):-
Objective To investigate the functional and histological changes in aging gerbil bladders.MethodsTwelve male gerbils were randomly divided into control group and aging bladder group,with 6 in each group.Experiment was conducted in gerbils of control group and aging bladder group 6 months and 24 months after normal feeding,respectively.Urodynamic examinations including irrigation volume,compliance and filling pressure of bladder were performed,bladder weight was obtained,bladder weight index was calculated,morphological observation was conducted with HE staining,ratio of amount of smooth muscle to collagen was obtained with double immunohistochemical staining,and electron microscope was used to evaluate the ultrastructure of bladder.ResultsCompared with those in control group,the irrigation volume and compliance of bladder significantly decreased in aging bladder group(P0.05).However,the bladder weight index was significantly lower in aging bladder group(P0.05).There existed degeneration in smooth muscle cells and organelles in aging bladder group.ConclusionThe function of aging bladder in gerbils is impaired,which may be related to the degeneration of bladder tissues.
4.Secretory carcinoma of breast in male: report of a case.
Yan XU ; Qun-Li SHI ; Xiao-Jun ZHOU ; Heng-Hui MA ; Hang-Bo ZHOU
Chinese Journal of Pathology 2009;38(10):707-708
Adenocarcinoma, Mucinous
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metabolism
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pathology
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Adult
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Breast Neoplasms
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metabolism
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pathology
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surgery
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Breast Neoplasms, Male
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metabolism
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pathology
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surgery
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Cadherins
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metabolism
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Carcinoma
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metabolism
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pathology
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surgery
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Carcinoma, Signet Ring Cell
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metabolism
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pathology
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Diagnosis, Differential
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Follow-Up Studies
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Humans
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Keratin-5
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metabolism
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Lymph Node Excision
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Male
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Mastectomy
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methods
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Mucin-1
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metabolism
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S100 Proteins
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metabolism
5.Stimulation of bone marrow fibroblst conditioned medium on megakaryocyte in vitro and platelet in vivo.
Yan-hong HUANG ; Xiao-yin ZHOU ; Men-qun TAN ; Lamei CHENG ; Guangxiu LU ; Qiru WANG
Journal of Central South University(Medical Sciences) 2005;30(6):726-728
Animals
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Blood Platelets
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cytology
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Bone Marrow Cells
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cytology
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Cell Differentiation
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Cells, Cultured
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Culture Media, Conditioned
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Cyclophosphamide
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Female
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Fibroblasts
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cytology
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Male
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Megakaryocytes
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cytology
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Mice
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Stem Cells
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cytology
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Thrombocytopenia
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chemically induced
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therapy
6.Correlation between age and general morphology of transverse section of cartilago costalis.
Bi XIAO ; Qun SHI ; Kai-jun MA ; Jian-jun YAN ; Xin CHEN
Journal of Forensic Medicine 2014;30(6):419-421
OBJECTIVE:
To study the correlation between age and general morphology of transverse section of cartilago costalis and its forensic significance.
METHODS:
Eighty-six corpses' cartilago costalis from the routine postmortem examination were collected and the morphological features of their transverse section were observed.
RESULTS:
With the increased age, there were regular changes in the color, structure, and material of the general morphology of transverse section of cartilago costalis. But the changes were not affected by gender.
CONCLUSION
The good correlation between general morphology of transverse section of cartilago costalis and age can be used to estimate age of the deceased rapidly.
Age Factors
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Autopsy
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Cadaver
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Cartilage/pathology*
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Humans
7.The study of cognition and treatment of ICU nurses on airway pressure alarm in mechanical ventilation patients
Xiao-Qun ZHU ; Zhi-Yan WANG ; Yan-Hong GAO
Chinese Journal of Modern Nursing 2012;18(11):1343-1345
Objective To study the cognition and treatment of ICU nurses on the mechanical ventilation alarm in mechanical ventilation patients,so as to provide theories for ensure the safety of nursing ensuring.Methods Summarized the reason of the airway pressure alarm,analyzed the treatment of nurses and strengthened the training on mechanical ventilation for nurses in ICU.Results The ventilator management abilities of ICU nurses was improved.Conclusions The promptly and accurately judging the ventilator alarm is the professional responsibility for nurses,which is the key point to improve the clinical success saving of critically ill patients.
8.Preliminary study of ALK3 downstream genes related to ventricular septum defect.
De-Ye YANG ; Hou-Yan SONG ; Huai-Qin ZHANG ; Xiao-Yan HUANG ; Xiao-Qun GUAN
Chinese Journal of Biotechnology 2003;19(3):267-271
To investigate the function of ALK3 gene, the gene regulation and the signaling pathway related to ventricular septum defect during heart development. The model mice with ALK3 gene knock-out via alpha-MHC-Cre/lox P system were bred. The mRNA expression level of control group was compared with that of experiment group and ALK3 downstream genes were screened using PCR-select cDNA subtraction microarray. The mRNA of control group was extracted from E11.5 normal mouse hearts, and that of experiment group, from E11.5 hearts of mice with alpha-MHC Cre(+/-) ALK3(F/+) genotype. It was found that the mice with ALK3 gene knock-out produced heart defects involving the interventricular septum. The platelet-activating factors acetylhydrolase and the transcription factor Pax-8 and so on, were down-regulated. However, the Protein Tyrosine Kinase (PTK) of Focal Adhesion Kinase (FAK) subfamily and beta subtype protein 14-3-3 were up-regulated in the alpha-MHC Cre(+/-) ALK3(F/-) mice. These data provide support that ALK3 gene played an important role during heart development. The platelet-activating factors acetylhydrolase and Pax-8 genes could be important ALK3 downstream genes in the BMP signaling pathway during interventricular septum development. PTK and beta subtype protein 14-3-3 might be regulatory factors in this pathway.
1-Alkyl-2-acetylglycerophosphocholine Esterase
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genetics
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metabolism
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14-3-3 Proteins
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genetics
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metabolism
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Animals
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Bone Morphogenetic Protein Receptors, Type I
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genetics
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metabolism
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Genotype
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Heart Septal Defects, Ventricular
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genetics
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Mice
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Mice, Knockout
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Oligonucleotide Array Sequence Analysis
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PAX8 Transcription Factor
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Paired Box Transcription Factors
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genetics
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metabolism
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Protein-Tyrosine Kinases
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genetics
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metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Signal Transduction
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genetics
;
physiology
9.A novel hemiacetal from the marine-derived fungus Penicillium citrinum.
Mini NI ; Xiao-yan ZHOU ; Xuan HE ; Qian-qun GU
Acta Pharmaceutica Sinica 2011;46(9):1098-1100
A novel hemiacetal, citrinacetal (1) was isolated from a marine-derived fungus Penicillium citrinum by column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC. Its structure and stereochemistry was established on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic methods. The NMR spectrum showed this compound exists in solution as a mixture of two stereoisomers. The cytotoxic effect of compound 1 was evaluated in A-549, HL-60, HeLa, and K562 cancer cell lines. However, compound 1 only displayed weak cytotoxic activity on HL-60 cell, with IC50 value 77.4 micromol x L(-1).
Acetals
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chemistry
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isolation & purification
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pharmacology
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Antineoplastic Agents
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chemistry
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isolation & purification
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pharmacology
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Chromatography, High Pressure Liquid
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HL-60 Cells
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HeLa Cells
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Humans
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K562 Cells
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Molecular Structure
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Penicillium
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chemistry
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Spectrometry, Mass, Electrospray Ionization
10.Clinical significance of detecting interleukin-2、interleukin-10、interleukin-13 in asthmatic children
xiao-hui, LU ; song-yan, ZHANG ; shu-qiang, QU ; hua, ZHANG ; li-qun, WANG ; yun feng, ZHANG
Journal of Applied Clinical Pediatrics 1986;0(02):-
Objective To evaluate the changes of peripheral blood interleukin(IL) 2, IL 10, IL 13 in the serum of asthmatic children and their effect on the pathogenesis of asthma.Method The serum levels of IL 2,IL 10,II 13 in 16 cases of asthmatic children and 10 cases of healthy controls were measured by ELISA methods.Results The serum levels of IL 2,IL 13 in asthmatic patients were significantly higher than those in healthy controls( P