Objective: To annually quantify the condylar growth from 7.5 to 15.5 years and identify the growth direction of condyle during the same period of time.Methods: The sample was obtained from Mathew's implant study with longitudinal cephalometric records of 13 untreated Class I subjects (8 Females, 5 Males). The cephalograms were taken annually from 7.5 to 15.5 years old. Reference lines were constructed based on three implants in mandibular corpus and linear and angular measurements performed. Results:It was found that the greatest amount of bone apposition at points of condylion and superior condylion occurred during the ages of 11.5 years to 12.5 years with the average value of (3.61?2.58) mm and (3.28?2.17) mm, respectively. The largest amount of bone addition at point of posterior condylion occurred much earlier between 8.5-9.5 years old, with average value of (1.92?1.16) mm. CRO angle was constantly decreased during the observation period. Conclusions:The current findings suggest that the condyle grows in forward and upward direction.

Histamine Antagonists ; administration & dosage ; therapeutic use ; Humans ; Phthalazines ; administration & dosage ; therapeutic use ; Rhinitis, Allergic, Perennial ; drug therapy

Objective To discuss how to properly fuse Anesthesia Information Management System(AIMS)and original Clinical Information System in a hospital.Methods 3key problems in AIMS are discussed i.e.data acquisition,anesthesia fee and offline run.Results AIMS expanded and enhanced the system's utility and adaptability,which was helpful to other clinical information system as a reference.Conclusion Developed and expanded from the original system,AIMS in anesthesia department is fully utilized in daily medical treatment,teaching,scientific research and management.

OBJECTIVE To investigate spectrum distribution of pathogens in patients with artificial airway and analyze their associated factors.METHODS The clinical data of 27 patients with tracheal intubation or tracheotomy from Mar 2005 to Mar 2006 were analyzed retrospectively.RESULTS Twenty seven patients were diagnosed as pneumonia.A total of 384 isolates of pathogens were collected from 258 sputum culture.The most were Gram-negative bacilli(293 isolates),and then were Gram-positive cocci and fungi.The four most pathogens were Pseudomonas aeruginosa,Stenotrophomonas maltophilia,meticillin-resistant Staphylococcus aureus(MRSA) and Acinetobacter baumannii.More multiple drug resistant(MDR) pathogens were detected in patients two weeks after intubation or tracheotomy than that after one week,and it was the same with sensitive rates to antibiotics of G-bacilli.CONCLUSIONS Patients with artificial airways have a higher morbidity of MDR pathogens and longer retention time of artificial airway can increase infection of MDR pathogens of lower respiratory tract.

Objective To study the effect of different concentrations of pravastatin treatment on macrophage polarity in mice .Methods The mice bone marrow sources of macrophages were cultured in vitro ,with the 0μmol/L sodium pravastatin group as control ,by giving 10 ,25 ,50μmol/L sodium pravastatin to conduct the drug intervention for 24 h .The enzyme linked immunosor-bent assay (ELISA) was used to detect the secretion of interleukin 10 (IL-10) and IL-12;the flow cytometry instrument was used to detect cell membrane CD16/32 ,CD206 expression;real time quantitative polymerase chain reaction (RT-qPCR) was adopted to detect toll-like receptor 4 (TLR4) ,myeloid differentiation factor 88 (MyD88) ,interferon regulatory factor 5 (IRF5) mRNA expres-sion .Results After the intervention of pravastatin sodium on macrophages ,as the pravastatin sodium concentration increase ,the expression of IL-12 and CD16/32 was decline ,while the expression of IL-10 and CD206 was risen ,which was accompanied by TLR4 ,MyD88 ,IRF5 mRNA expression down regulatyion ,and a dose dependent manner .Conclusion Sodium pravastatin promote the polarization of macrophages toward an anti-inflammatory macrophage phenotype (M2) ,this effect may be related with the anti-inflammatory effect of sodium pravastatin .

Hypoxia-inducible factor-I is the critical factor existed in mammal and human cells which plays an important role in maintaining the oxygen balance. Many hypoxia-responding genes can be activated by H1F-1. So, the relationship between HIF-land matrix matalloproteinases/stromal-derived factor-I/special CXC chemokin receptor/angiogenesis related factors is the hot spot in research of the tumor invasion and me-tastasis.

Medical literature novelty assessment plays a unique role in the advances of medical sciences. The idea of precision medical literature novelty assessment was thus proposed according to the precision medicine program of army general hospitals, which has promoted the development of clinical medicine in our hospital by finding out the precision points of literature novelty followed by precisely retrieving.

It is of great significance to maintain personal dignity of human organ donors.There are three problems that may exist in the human organ donation.At the stage of registration,the potential donors may face family kidnapping;at the terminal stage,living with dignity for the donors is difficult to guarantee;at the post-donation stage,there is lack of humane care for the remains of donors and their close relatives.Aiming at the above problems,this paper made an analysis from the theoretical aspect and put forward three ethical principles:the principle of autonomy,respect and humanitarianism.

It is still a challenge for surgeons to deal with the complex abdominal wall defect.The purpose of surgical treatment is not only to restore the integrity of the abdominal wall, but also to maintain the function of the abdominal wall.Accurate classification and partition of the abdominal wall defects before operation are the base of surgical procedure for complex abdominal wall defects.Reinforcement of the abdominal wall defects with mesh, component separation technique and tissue flap technique are important methods to achieve functional repair of the abdominal wall defects.

Objective To investigate the effect of intraperitoneal injection of compound sophora injection in the treatment of advanced gastric cancer patients with malignant peritoneal effusion.Methods 60 advanced gastric cancer patients with peritoneal fluid were randomly divided into two groups according to the different treatment meth-ods.A group of compound sophora injection with intraperitoneal therapy(group A),treatment 2 times per week for four weeks,Another group of compound sophora injection with vein therapy (group B),for 4 consecutive weeks.The efficacy of the two groups was compared.Results The effective rate of group A was 58.1%,which was higher than 27.6% of group B,the difference was statistically significant(χ2 =5.69,P <0.05).Conclusion Intraperitoneal perfusion with compound sophora injection can improve the effect in the treatment of peritoneal effusion in patients with advanced gastric cancer,and the adverse reaction is mild,it is worthy of clinical application.