OBJECTIVE:To provide reference for rational use of recombinant human granulocyte-colony stimulating factor (rhG-CSF) in cancer patients. METHODS:Referring to the expert advice and guideline of clinical application of rhG-CSF at home and abroad,DUE criteria on rhG-CSF for cancer patients was established;questionnaire was designed,and the medical re-cords of rhG-CSF in a third grade class A hospital was evaluated. RESULTS:The DUE criterion on rhG-CSF for cancer patients included 3 parts,such as drug indications,the course of medication and medication results,14 items in total. Through the imple-mentation of DUE,retrospective evaluation of 220 medical records showed that the application of rhG-CSF was up to the stan-dard in respects of drug indications,no contraindication,routine blood test and drug interaction monitoring at least twice every week,there still was irrational phenomenon. CONCLUSIONS:The established DUE criterion on rhG-CSF for cancer patients is with the characteristics of definite content,target and paracticabilitg,which can provide reference for the work development of clinical pharmacists.

Objective To investigate the effects of parecoxib pretreatment on the intrapulmonary shunt during one-lung ventilation in patients undergoing esophageal cancer resection.Methods Forty ASA Ⅰ or Ⅱ patients of both sexes,aged 25-64 yr,weighing 45-70 kg,with body height 156-178 cm,undergoing elective esophageal surgery,were randomly divided into 2 groups (n =20 each):normal saline group (group NS) and parecoxib group (group P).Parecoxib 40 mg (in normal saline 10 ml) was injected intravenously 30 min before anesthesia in group P,while the equal volume of normal saline was given instead of parecoxib in group NS.Anesthesia was induced with iv injection of propofol,fentanyl and rocuronium.Bronchial blocker was inserted after tracheal intubation and the correct position was confirmed by bronchoscopy.Anesthesia was maintained with iv infusion of propofol and remifentanil and intermittent iv boluses of atracurium.HR,MAP,SpO2 and mean airway pressure (Pmean)were determined at 5 min of two-lung ventilation,at 40 min of one-lung ventilation,and at 30 min after re-expansion of the collapsed lung (T0-2).Blood samples were taken simultaneously from jugular vein and radial artery for blood gas analysis.Intrapulmonary shunt (Qs/Qt) was calculated.Results There were no significant differences in hemodynamic parameters and Pmean between the two groups (P ＞ 0.05).PaO2 was significantly lower,while Qs/Qt was significantly higher at T1,2 than at T0 in groups NS and P (P ＜ 0.05).PaO2 was significantly higher,while Qs/Qt was significantly lower at T2 than at T1 in groups NS and P (P ＜ 0.05).Qs/Qt was significantly lower at T1,2 and PaO2 was significantly higher at T2 in group P than in group NS (P ＜ 0.05).Conclusion Parecoxib 40 mg injected intravenously at 30 min before anesthesia can reduce the intrapulmonary shunt during one lung ventilation in patients undergoing esophageal cancer resection.

Adolescent ; Adult ; Catheterization, Central Venous ; instrumentation ; Device Removal ; Humans ; Male ; Vena Cava, Inferior ; Vena Cava, Superior

Objective To summarize the postoperative experience of nursing infants undergoing total anomalous pulmonary venous correction.Method The clinical data of 54 infants undergoing total anomalous pulmonary venous correction were retrospectively reviewed for the summarization of nursing strategies.Result Forty nine patients were clinically cured and discharged, 2 voluntarily left the hospital without further treatment and 3 died of low cardiac output syndrome.Conclusion Early postoperative monitoring,protection of heart function and prevention of pulmonary hypertensive crisis are all critical for successful manipulation of total anomalous pulmonary venous correction.

Objective To compare the efficacy between microwave endometrial ablation(MEA) and abdominal hysterectomy(AH) in the treatment of abnormal uterine bleeding(AUB).Methods A total of 80 patients with AUB was divided into two groups,either receiving MEA(40 patients) or receiving AH(40 patients).The clinical efficacy,operation time,intraoperative blood loss,white blood cell(WBC) count,and neutrophil granulocyte rate(NGR) before and after operation were compared.Results The effective rate for abnormal uterine bleeding was not significantly different between MEA(97.5%,39/40) and AH(100%,40/40)(?2=0.000,P=1.000).As compared with AH,MEA was characterized by a shorter operation time(4.8?1.2 min vs 102.5?34.6 min;t=17.848,P=0.000) and less intraoperative blood loss(0 ml vs 138.3?40.6 ml;t=21.544,P=0.000).Conclusions Microwave endometrial ablation is a novel and efficient minimally invasive method for abnormal uterine bleeding.

Adolescent ; Humans ; Male ; Pigmentation Disorders ; pathology ; Skin ; pathology

Objective To summarize 380 cases of the laser hair removal experience. Methods Using 800nm's wavelength of wide 30ms diode laser hair removal machine, different energy of selection and the time interval were different according to the different positions such as: the lowest energy 19J/cm 2 of hairline was selected and treated once at the interval of 3 - 4W with increasing 1-2J/cm 2 every time, as a result of 3 -5 times had been taken for cure. For legs, the lowest dose was 36 J/cm 2 . The highest energy achieved at 25J / cm 2 with interval 7 weeks, and it needed to increase 2-3J/cm 2 every times, and a total of 3 to 5 times were used for the treatment. After treatment each time, no special care was needed. Results The pati ents were followed up for more than half a year to 1 year. Cure rate was 95 %. Thereinto 20 persons appeared several spots of pigmentations after treatment, and those disappeared within 2 to 4 months. Only 2 persons with dark color of the skin still had slight pigmentation after 1 year. Conclusion Hairs treated many times by laser show regeneration delay and become thin in quality in the newborn hairs with lighting in color. The different energy is chosen for the treatment according to the different hair position that finally achieves permanent hair removal.

Circulating tumor cells(CTCs)are essential for establishing recurrence and metastasis in malignant tumors.Detecting CTCs can help for early detection of the cancer metastases and recurrences,and also can help for evaluating prognostic and guiding treatment.CTCs detection technique mainly include screening and separation technology which contains immune magnetic separation technology and reverse transcriptasepolymerase chain reaction and so on.With the development of technique,there is a new technique named ctcchip contains both screening and separation functions.

Objective To establish a simultaneous determination method of cyclohexane,cyclohexanone and cyclohexanol in workplace air. Methods To collect the cyclohexane,cyclohexanone and cyclohexanol from the workplace air by pumping the air through the active carbon tube,resolve them with alcohol and then test the content of them by capillary gas chromatography. Results It was proved that these samples were separated effectively. The final measurement range of cyclohexane,cyclohexanone and cyclohexanol was 30-1 000 ?g/ml,20-1 000 ?g/ml and 20-880 ?g/ml respectively,the linear equation was y=257.4x+987.1 (r=0.999 9),y=239.9x+664.6 (r=0.9999 ) and y=192.4x+607.1 (r=0.999 9) respectively,the detection limit of was 1.5 ?g/ml,0.5 ?g/ml and 1.0 ?g/ml respectively. The minimum detectable concentration was 1.0 mg/m3,0.3 mg/m3 and 0.7 mg/m3 respectively (collected 1.5 L air sample). The efficiency of resolution was 90.1%,91.2% and 93.1% respectively. Conclusion The method is suitable for the simultaneous determination of the cyclohexane,cyclohexanone and cyclohexanol in the workplace air.

Objective To evaluate and the effects and safety of gemcitabine plus carboplatin (GEM+CBP) regimen and navebine plus cisplatin (NVB+DDP) regimens for aged patients with advanced non-small cell lung cancer (NSCLC). Methods The 60 cases of aged patients with NSCLC,over 65 years old and 35 cases beyond 70,were randomly and equally divided into 2 groups. Group A received 1 000 mg/m2 GEM at day 1 and 8,and 300 mg/m2 CBP at day 1. Group B underwent the therapy of 25 mg/ m2 NVB at day 1 and 8,and 80 mg/m2 DDP at day 1 and 3. Both were treated with 3 weeks as a cycle. Results Overall response rate was 43.3% in group A and 36.7% in group B without significant difference. The median survival time (MST) and disease median response time(DPT) was 9.2 and 4.4 months in A group,and 8.9 and 4.2 months in B group. MST,DPT and one year survival rate were similar in 2 groups. Toxicities: WHO grade Ⅲ/Ⅳ leukopenia occurred in B group was higher than that in A group. The frequence of phlebitis was significantly higher in group B than group A (P