Introduction: Choledocholithiasis is present in approximately 15-20% of patients with gallstone and laparoscopic common bile duct exploration has been effectively employed many cases currently. National Center for Health Development, Mongolian Ministry of Health, registered 23180 cases of bile duct diseases which were 3.4% of total diseases, 2.5% of total surgery, 12.2% of total gastrointestinal disease, 46.9% of total liver and biliary tract diseases between 2000 and 2006. Biliary tract diseases increased 2.4 times and bile duct surgery increased 5.2 times than 15 years ago in Mongolia. To compare open choledocholithotomy and laparoscopic choledocholithotomy for common bile duct stones. Materials and Methods: This study was carried out in Mongolian national second central hospital and Inner Mongolian first medical university hospital. The clinical data of the106 patients with common bile duct stones were analyzed between Арril 2015 and Арril 2016. Duration of operation, blood loss, postoperative complication, period of hospital stay and expenditure of treatment were compared in open choledocholithotomy and laparoscopic choledocholithotomy. All patients were placed on a “T” tube drainage. Results: In results of the duration of operation (p=0.001), blood loss (p=0.001) and period of hospital (p=0.01) were significantly lower in laparoscopic choledocholithotomy group Postoperative complications and gastrointestinal function recovery time were lower in laparoscopic group whereas expenditure of treatment were lower in open choledocholithotomy. Conclusion: In conclusion main advantages of laparoscopic choledocholithotomy were reduced duration of operation, blood loss, period of hospital stay and lower postoperative complications however costly.