1.A Study on the Relationship of Formaldehyde Exposure and Nitric Oxide Level in the Lung Tissue of Mice
Zi YE ; Yan YAN ; Zhisong LU
Journal of Environment and Health 1989;0(06):-
Objective To study the impact of gaseous formaldehyde exposure on the metabolism of nitric oxide (NO) in the lung tissue of mice. Methods The adult male Kunming mice were randomly divided into 4 groups, treated with gaseous formaldehyde (0,0.5,1,3 mg/m3) for consecutive 72 h in the simulated exposure chamber, the nitric oxide synthase (NOS) activities and the NO positive rate in mice's lung were measured with the reagent kits. Results The lower formaldehyde exposure (≤0.5 mg/m3 ) could decrease NOS activity (compared with the control, P
2.Doppler tissue imaging to assess right ventricular function in patients with chronic pulmonary hypertension
Pingping YAN ; Bin SUN ; Zi YE
Chinese Journal of Practical Internal Medicine 2003;0(01):-
Objective To investigate the right ventricular function of patients with chronic pulmonary hypertension using Doppler tissue imaging(DTI)and to evaluate the relationship between DTI parameters and pulmonary artery systolic pressure(PASP).Methods Thirty-five patients with chronic pulmonary hypertension and thirty-five healthy subjects underwent Doppler tissue echocardiographic evaluation of right ventricular function.The tricuspid lateral annular systolic velocity(Sm),early(Em)and late(Am)peak diastolic velocities,isovolumic contraction time(IVCT)and isovolumic relaxation time(IVRT)were acquired from apical 4-chamber view.Results When compared with control group,Sm,Ea and Em/Am values were found to be lower and Am,IVRT values higher in patients with chronic pulmonary hypertension.When all patients were analyzed,there was a significant positive correlation between PASP and IVRT(r=0.78,P
3.Research status of conbercept treating age-related macular degeneration
International Eye Science 2015;(8):1367-1369
Age-related macular degeneration( AMD) is one of the major reasons of blindness among the elderly in the developed countries. As AMD patients are increasing year by year, AMD has become one of the important topics of ophthalmic research to prevent blindness. Its pathogenesis is not fully understood, but many studies have shown that vascular endothelial growth factor ( VEGF ) plays an important role in the pathogenesis. With the development and application of anti - VEGF drugs, there are a variety of drugs applied to the disease. This article introduces conbercept for the treatment of AMD.
4.Relationships between Low Birth Weight and Insulin Resistance and Adult Cardiovascular Disease
zi-yan, ZHAO ; ping-yang, CHEN
Journal of Applied Clinical Pediatrics 2004;0(08):-
The nutritional status in early life have been gradually recognized that it can change the status of development and metabolism of adults.Epidemiological evidence and animal model study have found that low birth weight is the risk factors of adult metabolic syndrome and cardiovascular disease.Insulin resistance is a common pathophysiological basis.Renin-angiotensin system and insulin signaling systems interact to promote the development of insulin resistance.
5.Clinicopathological analysis of 34 cases of primary small intestine lymphoma
jun-liang, YAO ; xing-zhi, NI ; yan-ying, SHEN ; zi-zhen, ZHANG ; zi-li, XIAO
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(05):-
Objective To analyse the clinicopathological features of primary small intestine lymphoma(PSIL), and explore the relationship between clinical stage,histological findings,therapeutic modality and prognosis. Methods The clinical data of 34 cases of PSIL were collected,the pathohistological features and results of immunohistochemical examinations were obtained,and the follow-up findings were adopted for comprehensive analysis. Results Among these 34 cases of PSIL,abdominal pain or discomfort,gastrointestinal bleeding and abdominal mass were the predominant symptoms.PSIL mainly involved ileum,especially the bottom of ileum and ileocecal area.Among the 26 patients with follow-up for more than one year,the 1-year survival rate was significantly higher in patients without tumor perforation than those with tumor perforation(76.2% vs 20.0%)(P
6.Progress in researches on L-asparaginase targeted to childhood leukemia.
Yan-qin CUI ; Fu-xiong CHEN ; Zi-liang WU
Chinese Journal of Pediatrics 2004;42(3):227-230
Antineoplastic Agents
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administration & dosage
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adverse effects
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therapeutic use
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Asparaginase
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administration & dosage
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adverse effects
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therapeutic use
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Child
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Drug Administration Routes
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Drug Administration Schedule
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Forecasting
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Humans
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Leukemia
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drug therapy
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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drug therapy
10.The evaluations of the effect of stent implantation using multimodal computed tomography in ischemic cerebrovascular patients
Wenjie ZI ; Yan YANG ; Dazhi DUAN ; Jie SHUAI
Chinese Journal of Nervous and Mental Diseases 2010;36(2):92-95
Objective To evaluate the effect of stent implantation using Multimodal CT in patients with MCA and ICA stenosis. Methods Twenty-six patients with ischemic cerebrovascular disease who received MCA or ICA stent implantation in ChongQing xinqiao Hospital were recruited. Multimodal Stroke Assessment Using CT Score (MOSAIC) was used to evaluate the Neuroimaging data before stent implantation and Alberta Stroke Program Early CT Score (ASPECTS) to evaluate the time to peak (TTP) of CTP before and after stent implantation. Results Patients were divided into 4 groups based on scores: 4 scores, 5 scores, 6 scores, and 7 scores groups. the improvement degree was increase by 31.7%±14.17%、38.6%±15.73%、43.3%±10.3%、358.6%±13.45% in 4 scores, 5 scores, 6 scores, and 7 scores groups, respectively. The paired t test demonstrated that there were a statistically significant difference among four groups(H=10.673, P <0.05). Preoperative MOSAIC score was positively correlated with the improvement of ASPECT score for TTP, with a correlation coefficient of 0.579 ( P <0.002). Conclusions Multimodal CT is a sensitive assessment for the evaluation of ischemic cerebrovascular disease and patients with a higher MOSAIC score may benefit more from stent implantation.