Objective To investigate the effect of itraconazole capsules combined with clotrimazole on the quality of life and the incidence of adverse reactions in patients with fungal vaginitis. Methods From May 2014 to February 2016, 106 cases of fungal vaginitis patients were randomly divided into single drug group and combination drug group, 53 cases each group. The single drug group was treated with clotrimazole vaginal tablets, the combination drug group was treated with itraconazole capsules combined with clotrimazole vaginal tablets, both groups were treated for 15 d. Quality of life score(QOL-100) before and after treatment was compared, and the incidence of adverse reactions and clinical efficacy between the two groups were compared as well. Results The total effective rate was 96.23％ (51/53) in the combination drug group and 81.13％ (43/53) in the single drug group, the difference was statistically significant (P<0.05); The QOL-100 score of the combination group was higher than that of the single drug group, the difference was statistically significant (P<0.05); However, there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Itraconazole capsules combined with clotrimazole vaginal tablets in the treatment of fungal vaginitis can effectively improve patients' quality of life, the effect is exact and no obvious adverse reactions was observed.

Objective To study the association of SNP of the AdipoR1 gene with T2DM in Xi’an population. Methods The amplification refractory mutation system(ARMS) analysis and gene sequencing were used to investigate the AdipoR1 gene polymorphism in 100 type 2 diabetics and 84 normal control subjects. Results (1) The genotype and allele frequencies of -106A/G, 5843A/G were not significantly different between type 2 diabetics and normal control subjects. (2) The diagnosis age of diabetics was significantly younger in AdipoR1 5843GG genotype group than in other genotype groups. Conclusions The data implicate that the AdipoR1 gene -106A/G and 5843A/G polymorphism may be not associated with pathogenesis of T2DM. AdipoR1 5843 GG genotype may be associated with the earlier diagnosis of T2DM

Objective To assess the efficacy of high intensive narrow band blue light and red light combined with Cuochuangling granule,a traditional Chinese medicine (TCM),in acne vulgaris(AV).Methods Forty-two patients with mild to moderate AV were randomly divided into two groups.combination group(n=25)receiving photothempy with blue light and red light plus oral Cuochuangling granule,TCM group(n=17)treated with oral Cuochuangling granule alone.Cuochuangling granule was given thrice daily,and phototherapy was performed at a dose of 48 J/cm2 with a least interval of 48 hours.All patients were treated for 4 weeks.Before and after the treatment,sebum secretion level and water content in stratum corneum were measured by photometry and capacitance method,respectively,skin pH value was examined,and the number of lesions was counted.Results The total effective rate was 84%in the combination group,and 71%in TCM group.A significant increase was observed in the clearance rates of total lesions and inflammatory lesions in the combination group compared with the TCM group(both P＜0.01).The water content in stratum corneum increased from 210.47 to 294.70(P＜0.01)in the combination group,and the increase was greater than in the TCM group.No significant changes were noticed in the sebum secretion level or skin pH value alter the treatment in either group.Conclusions Phototherapy combined with Cuochuangling granule is highly effective in the treatment of mild to moderate acne,with an increase in the water content in stratum corneum after treatment.

Magnesium and its alloys possess the features of low density,high strength and rigidity,good biocompatibility and biodegradability.Their elastic modulus is similar to human bone,which endows them with a broad application prospect in the field of orthopedic biomedical materials.This paper reviews the current research status of magnesium and its alloys as the orthopedic implant materials and as porous scaffold materials in bone tissue engineering.Methods to improve corrosion resistance of magnesium-based metals ale briefly described as well.

OBJECTIVE:To discuss the status quo and the development strategy of the study of the processing of Chinese herbal medicine.METHODS:The physical-chemical property,the technology transfer and the qualitation and quantitation reported in the literature about the processing of Chinese herbal medicine were analyzed and summarized.The status quo and the current methods for the study of processing of Chinese herbal medicine were expounded and its development strategy was put forward in view of the role and importance of the processing study.RESULTS & CONCLUSION:To develop the study on the processing of Chinese herbal medicine,it is essential to strengthen literature research and summarizing of experiences as well as the combination of processing synergy with clinic practice,attach great importance to the guiding effect of traditional Chinese medicine theory on the study of physical-chemical study in the processing of Chinese herbal medicine,and strengthen study on the key issues including the processing technology of Chinese herbal medicine and the quality control of decoction pieces.

To compare the therapeutic effects between acupuncture plus sacral injection and simple acupuncture for intervertebral disc hemia.Methods:The patients with lumbar intervertebral disc hernia at the age of 30-45 years old were divided into No.1-80 upon their visiting order,with odd number as Group A and even number as Group B.Group A was treated by acupuncture plus sacral injection,and Group B was treated by simple acupuncture.Results:The clinical effective rate was higher in Group A than in Group B,with significant difference (P＜0.05).Conclusion:Acupuncture plus sacral injection had the better therapeutic effect than simple acupuncture in treating lumbar intervertebral disc hernia.

Objective To construct the expression vector maspin/pEFIRES-N so as to study maspin gene on the inhibition of the growth,invasion,and metastasis in hepatocellular carcinoma.Methods The full lenth of maspin gene was cloned and ligated to the expression vector pEFIRES-N digested by EcoRⅠ+XbaⅠ by T4 DNA ligase.The recombinant vector maspin/pEFIRES-N was stably transfected into hepatocellular carcinoma MHCC-97 cell line,and the expressive changes of maspin gene were detected.Results The recombinant plasmid was amplified in the E.coli.JM109.After the identification and sequencing,the reconstructive plasmid was confirmed containing the correct and full nucleotide sequence of maspin gene and the mRNA and protein level of maspin gene were up-regulated in hepatocellular carcinoma MHCC-97 cells.The proliferation and invasion of MHCC-97 cells was inhibited.Conclusion The expression vector maspin/pEFIRES-N was constructed successfully and could be expressed in eukaryotic cells.

Non-suicidal self-injury is common in adolescents. At present, the pathological mechanism of non-suicidal self-injury is still unclear, and there is a lack of objective biological markers in diagnosis and treatment, which is an urgent problem to be solved in clinical diagnosis and treatment. The magnetic resonance imaging is an important technique to explore the imaging mechanism of non-suicidal self-injury. The purpose of this review is to systematic evaluation of the latest research results of magnetic resonance imaging of non-suicidal self-injury. It was found that non-suicidal self-injury in people without other mental disorders showed abnormal damage in the orbitofrontal, the dorsolateral prefrontal lobe, the medial prefrontal lobe, the ventrolateral prefrontal lobe, the amygdala, the cingulate gyrus, the supramarginal gyrus, the amygdala, the hippocampus, the insular, the corpus callosum, the thalamus, the putamen, the dorsal striatum, the cuneate prefrontal lobe and the right temporal lobe. These areas are the core areas related to emotional processing, decision-making, cognition and movement. Non-suicidal self-injury with other mental disorders such as borderline personality disorder and depression may be affected by underlying diseases and exhibit different damage patterns, which showing abnormal brain regions related to emotional network, decision-making, social cognition and exercise.The results of this review can be helpful for the future study of the magnetic resonance imaging mechanism of non-suicidal self-injury.

Objective To observe the effect of tai chi chuan on anneal dyspnea and endurance stamina of patients with chronic obstructive pulmonary disease (COPD).Methods 80 COPD patients were randomly divided into control group (n=40) and training group (n=40). The common therapy of two groups was the same; but the training group was added with Chen style tai chi chuan training for 30 minutes one day. At the same time, all patients were evaluated about the dyspnesa exponent before and after 3 months training.Results There were no significant differences in FEV1(%), FEV1/FVC(%),heart rate and breath frequency/minute before and after treatment (P>0.05) between two groups, but in dyspnea exponent, there was a significant difference between two groups (P<0.05).Conclusion Tai chi chuan training can reduce the symptom of COPD patients.

Acupuncture Points ; Acupuncture Therapy ; Adolescent ; Adult ; Aged ; Female ; Hiccup ; therapy ; Humans ; Male ; Middle Aged ; Young Adult