Objective To observe absorption of exogenous nerve growth factor(NGF) between normal newborn rats and newborn rats with hypoxidosis.Methods Thirty-two healthy newborn rats(7 days of age) were divided into experiment group and normal group.Experiment rats were made into hypoxic-ischemic brain damage(HIBD) model.NGF labeled with()~(125)I or()~(125)I was injected into the rats abdominant.All of the rats were killed and brain was removed after 30 minutes.The brain was dissected into basal forebrain,forehead cortex,hippocampus,thalamus,cerebellum,smellorb,pituitary tissue samples were assayed for radioactivity in a two-channel gamma counter.Results Absorptions of two groups(()~(125)I-NGF) were significantly higher than those of()~(125)I in basal forebrain,cortex,hippocampus,cerebellum.Absorptions of hypoxic group were significantly higher than those of control group in cortex,hippocampus,cerebellum.Conclusions NGF can penertrate blood brain barrier of newborn rats into brain regions by means of peripheral administration.Early application of NGF for treating hypoxic-ischemic encephalopathy(HIE) is feasible.

Microglia(MG)is recognized as the main immune effector in central nervous system injury and disease.MG can regulate the tumorigenesis and development of brain metastases tumor(BMT)by different ways.Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.

Helical tomotherapy is the radiation treatment device that combined CT imaging with a linear accelerator, and capable of implementing 360-degree intensity modulated radiation therapy (IMRT), MVCT image guidance, adaptive therapy, stereotactic radio-surgery (SRS) and stereotactic body radiation treatment (SBRT) etc. A very broad spectrum of tumor can be treated by helical tomotherapy.

Objective To investigate the effect of lead aVR on recent prognosis in patients with non -ST -elevation acutecoronary syndrome(NSTE -ACS).Methods 195 patients with NSTE -ACS were divided into ST segment elevation in lead aVR group(n =54 cases)and non -ST segment elevation in lead aVR group(n =141 ) according to ST segment elevation in lead on admission;clinical data,laboratory index and coronary artery lesion were recorded,and major adverse cardiac (MACE)in hospitalization time were also recorded.Results Compared with non -ST segment elevation in the lead aVR group,the heart rate of ST segment elevation in the lead aVR group was faster[(85.4 ±12.0)beats per minute vs.(79.3 ±13.2)beats per minute,t =2.959,P <0.05],systolic blood pressure and diastolic blood pressure were higher[(145.0 ±20.3)mmHg vs.(136.0 ±19.4)mmHg,t =2.874,P <0.05];NT -proBNP[(743.9 ±125.8)pg/mL vs.(416.4 ±95.3)pg/mL,t =19.625,P <0.05],cTnI[(3.4 ± 1.0)ng/mL vs.(1.2 ±0.4)ng/mL,t =21.994,P <0.05],CK -MB[(31.5 ±9.8)ng/mL vs.(19.8 ±6.5)ng/mL, t =9.682,P <0.05]were higher (P <0.05);LVEF were lower[(50.1 ±5.2)% vs.(53.8 ±5.7)%,t =4.153, P <0.05];the rate and amplitude of low ST segment in outside lead aVR also was higher[(9.5 ±3.8)mm vs. (7.4 ±2.8)mm,t =4.224,P <0.05];the rate of left main and three -vessel disease in ST segment elevation in lead aVR group were higher (P <0.05).Compared with non -MECE group,proportion of ST segment elevation in lead AVR on admission was higher (P <0.05).Logistic regression analysis showed that heart rate(OR =1.472),NT -proBNP(OR =1.732),cTnI(OR =1.893),left main coronary artery(OR =2.478)and three -vessel disease (OR =2.310)were risk for ST segment elevation in lead AVR(P <0.05).Logistic regression analysis also showed that ST segment elevation in lead AVR were risk for MACE(OR =1.474).Conclusion ST segment elevation in lead AVR has close relationship with large area of myocardial ischemia,and patients prognosis is poorer,which may be independ-ent risk factor for the recent outcomes of patients with NSTE -ACS.Early record of the change in the case of aVR lead ECG ST segment NSTE -ACS patients is of important value in evaluation of the condition and prognosis.

Newborn due to low birth weight caused by preterm or fetal growth restriction will have an adverse effect on kidney development. In adulthood,the long-term adverse effects of low birth weight are associ-ated with a variety of kidney disease. Current studies suggest that low birth weight may participate in a variety of kidney disease development and progression by affecting the nephron number,the function of the vascular struc-ture and the endocrine level. This paper mainly reviews the relationship between low birth weight and kidney dis-ease.

Objective To evaluate the teaching quality of AIDS and drug abuse and to provide evidences for teaching improvement.Methods Quantitative research and qualitative research was combined.Questionnaire including evaluation of curriculum,teachers and teaching quality was conducted among 273 students majored in anesthesiology and clinical medicine (2006 grade) as well as in forensic medicine,laboratory and stomatology (2008 grade) in quantitative research.Observation and indepth interview were used in qualitative research to observe the teaching process and receive students'feedback.Information about students' evaluation criterions and attitude toward teachers were collected by qualitative research.Chi-square test and descriptive statistic were used with SPSS 13.0.Results 90.8％ students thought this lesson was necessary and important and the contents were accepted by them.24.2％ students expected increasing study hours and having practice classes.Evaluation of course time,contents and importance were different by students of different majors.Average scores of students' evaluation on teachers' quality,teaching contents and teaching methods were 25.2,22.4,11.0,respectively.Three aspects of teaching methods got the lowest scores:vivid (2.71 points out of 3.0 points),interaction (2.71 points out of 3.0 points) and flexibility (2.72 out of 3.0 points).Interview results demonstrated that students have diversified demand for teaching methods and expect to increase practice lessons and multimedia teaching as well as to effective communicate between teaching and learning.Conclusions Course of AIDS and drug abuse is accepted by students.As a whole,students are basically satisfied with teachers,however,teachers and related sectors should pay more attention to teaching method improvement and teaching skill enhancement.

Objective To evaluate the accuracy of the soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and lipopolysaccharide binding protein (LBP) as diagnostic indices for neonatal serious bacterial infections (SBI). Methods A total of 171 newborns were enrolled in the study, and were classiifed into SBI group (including early-onset and late-onset), non-SBI group according to clinical manifestations, laboratory examinations and the time of disease onset. Serum sTREM-1, LBP and C-reactive protein (CRP) levels were measured. Receiver operator characteristic curve (ROC) was drawn, and the area under curve (AUC) was calculated. Each index was evaluated for the diagnostic value of neonatal SBI. Results The sTREM-1 and LBP levels were signiifcantly higher in SBI group than those in non-SBI group (P=0.000). The AUC of ROC for sTREM-1, LBP and CRP in early-onset SBI was 0.888, 0.839 and 0.706, respectively. The AUC of ROC for sTREM-1, LBP and CRP in late-onset SBI was 0.860, 0.865 and 0.705, respectively. Conclusions Both sTREM-1 and LBP are useful for the diag-nosis of neonatal SBI.

Objective To study the the current situation of sexual for college students in luzhou area and to provide basis for their sexual health education .Methods 2 226 college students from four colleges in luzhou area were investigated by stratified clus-ter sampling method ,SPSS11 .5 software was used to analysis the results .Results 59 .62% of the students′knowledge was mainly from the media ,the test for sexual knowledge of college students′was satisfactory ;58 .94% of college students would like to com-municate and communication about sex and love ,84 .61% of the students thought that college students should have correct love and chastity view ,82 .95% of the students thought that should make efforts to prevent venereal disease and AIDS ,55 .27% of the students were firmly opposed to marriy during school study ;75 .15% of the students were firmly opposed to premarital sexual be-havior ,44 .44% of the students minded that lover once had sex ,36 .56% of the students broken up immediately when found that loveer had sex before .Conclusion The college students′sexual maturity in advance but knowledge of sex education relative lag , making them for many sexual problems and phenomena ,so scientific and systematic sexual health education should be strengthen in students .

Objective To compare the effect of different dose human immunoglobulin for intravenous injec-tion( IVIG) in the treatment of Kawasaki disease ( KD) .Methods According to different time ,55 children with KD were divided into two groups.26 patients between January 2002 and February 2006 were selected as group A,while 29 patients between October 2006 and June 2013 were selected as group B .Patients in group A were given IVIG 0.4 g· kg-1 · d-1 ×5d,while group B was given IVIG 2 g· kg-1 · d-1 ×1d.Then,the time of fever-reducing and CAL of the two groups were compared .Results The time of fever-reducing in group A was (38 ±4) h,that in group B was (34 ±3)h,there was significant difference between the two groups (t=4.15,P<0.05).The incidence rate of CAL in group A was 6.9%,which was higher than 6.1%in B group,but the difference was not statistically signifi-cant(χ2 =0.253,P>0.05).Conclusion The treatment of KD with IVIG 2 g· kg-1 · d-1 ×1d is more superior than IVIG 0.4 g· kg-1 · d-1 ×5d.

Recently,paclitaxel has been used as a new agent on patients with advanced esophageal cancer,and several studies have demonstrated that paclitaxel and paclitaxel-based regimens have significant activity in patients with advanced esophageal cancer and showed highly response rates than the combination of 5-fluorouracil (5-Fu) and cisplatin.However,there have been some problems which need to be solved such as drug-resistance,side effect,and so forth.The new medicament form of paclitaxel can not only depress poison without anti-allergy but also raise medicament curative effect as well as the pharmacal concentration.Although most of the research on the new medicament form of paclitaxel are still limited in the stage of laboratory,it has possessed potential advance in the treatment of advanced esophageal cancer.