Objective To observe curative efficacy of hepatocyte growth factor(HGF) in treatment of children with liver damage.Methods Two hundred and four children with liver damage were divided randomly into control group and teatment group.The control group was chosed energy compounds at the same time of primary disease was treated,on the basis of the control group,the treatment group was chosed HGF to protect liver and decline enzyme,to observe efficacy of liver shrink and decline enzyme in the course of treatment.Results After the treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST) and total bilirubin(TBIL) decreased significantly in the treatment group with HGF.The total clinical efficacy was 96.5%,while the total clinical efficacy of the control group was 75.0%.The curative efficacy of treatment group surpassed that in the control group,the difference was obvious(?~2=5.27 P

Formaldehyde ; Humans ; Microdissection ; Paraffin Embedding ; Proteomics ; methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Tissue Fixation

Objective To study the expression and clinical significance of vascular endothelial growth factor(VEGF)and soluble vascular cell adhesion molecule-1(sVCAM-1)in children with Henoch-Schonlein purpura(HSP).Methods The levels of plasma VEGF and sVCAM-1 were measured in 58 children with HSP and 23 normal children by enzyme-linked immunosorbent assay(ELISA),respectively.Results The plasma levels of VEGF and sVCAM-1 of HSP children at acute stage were significantely higher than those of HSP children at the remission stage and those of the controls(Pa

Acute Disease ; Adult ; Female ; Herbicides ; poisoning ; Humans ; Inflammation ; therapy ; Male ; Paraquat ; poisoning ; Poisoning ; therapy ; Retrospective Studies ; Survival Rate ; Young Adult

Objective To explore the outcome relationship between the baseline blood pressure level and the early antihypertensive therapy of acute ischemic stroke for 3 months. Methods A total of 828 patients who were admitted to hospital within 48 hours of onset and diagnosed with acute ischemic stroke with hypertension through imageological examination from August 2009 to May 2013 were collected. They were divided into 140～160 mmHg group (n=276),160～180 mmHg group (n=350),180～200 mmHg group (n=158),and 200～220 mmHg group (n=44) according to the level of systolic pressure at the time of enrollment,and given randomly or not given antihypertensive therapy. For the patients receiving the antihypertensive therapy,the blood pressure was reduced by 10%～20% within 24 hours,the systolic pressure and diastolic pressure were lower than 140 mmHg and 90 mmHg respectively at 7 days,and maintained at this level for 2 weeks. For the patients not receiving the antihypertensive therapy,antihypertensive drugs were discontinued or not given,and all patients were measured,with the blood pressure levels recorded. The mortality and good prognosis rate were compared at 3 months after discharge. Results Through 3 months of follow-up,the mortality of patients with antihypertensive therapy in the 140～160 mmHg group was significantly higher than that of those without antihypertensive therapy (13.7% vs 5.8%,P<0.05),the good prognosis rate was significantly lower than that of those without antihypertensive therapy (65.5% vs 77.4%,P<0.05),there was no statistically significant difference in mortality and all-cause mortality between 160～180 mmHg group,180～200 mmHg group,and 200～220 mmHg group (9.2% vs 13.4%,11.8% vs 12.3%,13.6% vs 9.1%,P>0.05),and the difference in good prognosis rate was not statistically significant (71.8% vs 62.6%,69.4% vs 60.3%,54.5% vs 59.1%,P>0.05). Conclusion Patients with acute ischemic stroke should not receive antihypertensive therapy when blood pressure is elevated mildly (SBP 140～160 mmHg);the impact of antihypertensive therapy on 3-month outcome is neutral in case of moderate to high blood pressure elevation (SBP 160～220 mmHg).

Adult ; Adult Stem Cells ; Humans ; Research ; trends

Acupuncture Therapy ; Endophthalmitis ; etiology ; therapy ; Facial Paralysis ; complications ; Humans ; Male ; Middle Aged

Antibodies, Monoclonal ; administration & dosage ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; administration & dosage ; Carcinoma, Non-Small-Cell Lung ; drug therapy ; Cetuximab ; Drug Delivery Systems ; Humans ; Lung Neoplasms ; drug therapy ; Protein Kinase Inhibitors ; administration & dosage ; Quinazolines ; administration & dosage ; Receptor, Epidermal Growth Factor ; antagonists & inhibitors

Autoimmune diseases (AID) are characterized by autoimmune disorder, as autologous tissue is attacked by the autoimmune system. It is reported that the imbalance of autoimmune tolerance and ingrained inflammatory response are the core events of AID undoubtedly. Peroxisome proliferator-activated receptor γ (PPARγ) which belongs to the nuclear hormone receptor superfamily is a ligand activated transcription factor. PPARγ combines with retinoid X receptor (RXR) to form heterodimer. When PPARγ is activated, the complex regulates gene expression by binding to a specific peroxisome proliferator response element (PPRE). In addition, PPARγ has diversified biological functions, playing important roles in regulating metabolism, controling inflammation, modulating glucose and lipid metabolism, ameliorating atherosclerosis, anti-tumor, and regulating immune response. However, recently researches indicate that PPARγ participates in the pathogenesis of AID. PPARγ plays key roles in regulating activation and polarization of macrophages, function of dendritic cells, proliferation and differentiation of T cells, and modulation of the function of related stromal cells. This article summarizes the biological functions and signal transduction pathways of PPARγ and the protective effects of agonists of PPARγ on AID, aiming to provide theoretical support for the research of mechanism and prevention and treatment of AID.

Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Gene Rearrangement, T-Lymphocyte ; Humans ; Lymphoma ; genetics ; Lymphoma, Extranodal NK-T-Cell ; genetics ; Lymphoma, Large-Cell, Anaplastic ; genetics ; Lymphoma, T-Cell, Peripheral ; genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; methods ; Young Adult