Adenoma ; pathology ; Carcinoma, Renal Cell ; pathology ; Diagnosis, Differential ; Female ; Humans ; Kidney Neoplasms ; pathology ; Middle Aged

Objective To approach rehabilitation nursing measures in using the allogeneic ten-don to re-establish the anterior cruciate ligament of knee through the tibia twin tunnel under arthroscopy.Methods Mental nursing and direct functional exercises was given to 30 patients who received this kind of operation from November,2006 to July,2007,and functional exercises of flection and extention of knee joint by steps,functional exercises of muscle force of quadficeps muscle and back muscle group of legs and the correct using of artificial brace of knee joint.Results Range of joint motion could reach 95°after 2 weeks and 125°after 4 weeks postoperation.Score of joint function(Lysholm)could reach(74.8±5.7)after 6 weeks,(80.0±2.3)after 9 weeks,(91.8±3.4)after 12 weeks, and(94.5±2.2)after 1 year.Conclusion Selective perioperative rehabilitation nursing instruction is the important guarantee of function recovery.

Objective To investigate the effect of Suanzaoren Decoction on hippocampus, cortex BDNF and TrKB gene expression in depression model rats. Methods Depression rat models were established by social-isolated raise and chronic stress stimulation. Suanzaoren decoction was administrated to the models. RT-PCR was adopted to detect the expression of mRNA BDNF and TrKB genes. Results The mRNA expression of BDNF and TrKB in cortex of Suanzaoren decoction high dose group、medium dose group and clomipramine group(0.213±0.094, 0.639±0.023, 1.032±0.015, 1.089±0.014, 1.580±0.012, 1.860±0.019)were all higher than the model group(0.032±0.008, 0.001±0.000), showing a significant difference among four groups (P<0.01), and the mRNA expression of BDNF and TrKB in hippocampus of Suanzaoren decoction high dose group, medium dose group and clomipramine group(0.213±0.094, 0.639±0.023, 1.032±0.015, 1.089±0.014, 1.580± 0.012, 1.860±0.019)were higher than the model group (0.021±0.015, 0.125±0.013), there was a significant difference between four groups(P<0.01). Compared with the model group, the mRNA expression of low-dose group of Suanzaoren decoction in both cortex and hippocampus of BDNF and TrKB was not significantly different to the model group(P>0.05). Conclusion Suanzaoren decoction can increase the expression of BDNF and TrKB gene, promote neuronal proliferation, and resist depression.

Adult ; Diagnosis, Differential ; Female ; Histiocytoma, Malignant Fibrous ; immunology ; pathology ; Histiocytosis, Langerhans-Cell ; immunology ; pathology ; Histiocytosis, Sinus ; immunology ; pathology ; Hodgkin Disease ; immunology ; pathology ; Humans ; Ki-1 Antigen ; metabolism ; Lewis X Antigen ; metabolism ; Lung ; immunology ; pathology ; Lung Neoplasms ; immunology ; pathology ; Lymph Nodes ; immunology ; pathology

Objective:To discuss the role of clinical pharmacists in perioperative drug treatment for a patient after renal transplan-tation. Methods:Clinical pharmacists participated in the drug therapy for a patient after renal transplantation. Pharmaceutical care and health education were performed for the patient in the aspects of immunosuppression, anti-hepatitis B virus, gastric mucosa protection, diarrhea, acute rejection and the other treatment programs. Results:The participation of clinical pharmacists in the clinical treatment for the patient improved therapeutic scheme and promoted therapeutic efficacy. Conclusion:The participation of clinical pharmacists in clinical drug therapy for patients can provide individualized service to improve reasonable, effective and economical drug use.

60 Chinese skulls(30 males and 30 females) from Liaoning province of the People's Republic of China were measured, By applying the multiplestepwise discriminant function, sexual diagnosis of the maxillary, frontal, occipital and parietal bone were carried out, 12 discriminant equation for sexual diagnosis have been obtained,The diseriminant rate of equations with accuracy tests on the same series of crania results in 66.7～93.3% of the cases analyzcd

Objective To study the morphological characteristics of craniofacial contour in ageing.Methods Craniofacial morphology was examined in a sample of 20 young men and 20 old men.By multi-slice helical CT,a computer reconstruction technique was used to produce three dimensional images and 3-D reconstruction data were analyzed quantitatively.Results Compared with the young men,old men increased with midface(Zy-Zy),lower face(Go-Go),supraorbital projection(Fb-Sr,T-So),midface depth (N-Po),and lower facial depth(T-Gn),and decreased with maxillary height(N-Sd) and upper facial width(Ft-Ft,T-T).Conclusion Facial width and depth and supraorbital projection tend to be increased and facial height decreased with ageing.

Antibody-drug conjugate (ADC) has become an effective method for treating various diseases, especially cancer, due to its clear target and good selectivity in clinical practice. However, the monoclonal antibodies in traditional ADC have poor tissue permeability, high modification costs, pose risks such as immunogenicity and immunotoxicity. The nanobody (Nb) which is extracted from the blood of camel animals, is the smallest antibody fragment known to have complete antigen binding ability. It has advantages such as strong tissue permeability, strong specificity, low immunogenicity, and high stability, and can replace traditional monoclonal antibodies to participate in the construction of nanobody-drug conjugate (NDC). This article reviews and discusses the advantages of Nb structure, the construction and application of NDC in the hope of providing ideas for the research and development of NDC.

Objective To investigate the expression level of tumor necrosis factor α( TNF-α) , heat shock protein 70 (HSP70) in serum and to analyze the correlation of TNF-αand HSP70 with the incidence of type 2 diabetes mellitus (T2DM) among Hui and Han nationalities in Ningxia .Methods Using the method of case-control study and according to the inclusion and exclusion criteria of case and control groups , 225 patients with T2DM who were treated by Department of Endocrinology and 600 healthy people during health checkups were enrolled in the study between October 2011 and October 2012 .A double antibody sandwich enzyme-linked immunosorbent assay ( ELISA) was used to determine the protein expres-sion levels of TNF-αand HSP70 in serum.Results The expression levels of TNF-αin the total population investigated and Hui population in T2DM group were significantly higher than in the control (t=-3.512,-3.791,all P<0.01).The difference in expression levels of TNF-αbetween the Han people of T 2DM group and control group , and that in the expression levels of HSP70 between the case group and control group were not statistically significant ( t =-0.565,-0.020,-1.251,-0.809,all P>0.05).The elevated serum levels of TNF-αincreased the risk for T2DM(OR=1.500, 95%CI:1.075-2.093,P=0.017).The expression levels of TNF-αin the total people, case and control of Hui people were significant lower than the homologous Han people (t=9.373,2.223,9.734, all P<0.01 or 0.05).Pearson analysis showed that the high expression of TNF-αwas positively correlated with blood glucose level (r=0.110,P=0.001),but there was no correlation between the high expression of HSP 70 and blood glucose level (r=0.023, P=0.504).The result of multiple logistic regression analysis indicated that gender and waist-to-hip ratio(WHR) were risk factors for high levels of TNF-α(P<0.01 or 0.05)while HSP70 and nationalities were protective factors.Systolic blood pressure(SBP) and WHR were risk factors for the high level of HSP70(all P<0.01), but TNF-αwas protective factors.HSP70, TNF-α, gender, family history, BMI, SBP, triglycerides(TG), low density lipoprotein cholesterol (LDL-C), alanine trans-aminase(ALT), and psychological stress were risk factors for T2DM, but high density lipoprotein cholesterol (HDL-C) was a protective fac-tor.Conclusion The high expression of TNF-αin serum is closely related to elevated fasting plasma glucose ( FPG) and T2DM onset.The expression level of TNF-αin serum in Hui people is lower than in Han people ,possibly correlated with ethnic heredity.The high expression of HSP70 in serum may induce T2DM onset.

Castleman Disease ; complications ; metabolism ; pathology ; surgery ; Dendritic Cell Sarcoma, Follicular ; complications ; metabolism ; pathology ; surgery ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Receptors, Complement 3b ; metabolism ; Thoracic Diseases ; complications ; metabolism ; pathology ; surgery ; Thoracic Wall ; Vimentin ; metabolism