Objective To investigate and analyze the economic burden and family burden among patients with depression.Methods 180 patients who diagnosed with depression according to Diagnostic and Statistical Manual of Mental Disorders-version Ⅳ (DSM-Ⅳ) had been enrolled randomly.The self-made economic costs questionnaire and the Family Burden Scale of Diseases (FBS) were utilized for investigation.168 participants finished this study.Results The per capita total economic cost of patients was 21 650 Yuan,direct economic costs was 6 806 Yuan,indirect costs was 14 844 yuan.The total economic costs,direct economic costs and direct medical costs of hospitalized patients were significantly higher than outpatients.The total economic cost per capita,indirect economic costs,costs decreased by work delays and work ability impairment of urban patients were significantly higher than rural patients.Four factors of FBS such as subjective feeling,family life,home entertainment and mental health had higher positive answer rate,which was above 60％.The positive answer rate of family relationship and physical health was lower than 40％.Conclusions Patients with depression suffered high economic burden and family burden.

Our hospital adopted a series of measures in its nursing reform so as to meet the needs of its pa- tients and improve its nursing quality. The steps include: appointing head nurses via competition; rewarding the best performing nurse and firing the worst one; adopting a ranking list with regard to nursing quality; implementing the mode of holistic nursing; carrying out flexible shifts and shift according to the needs of both patients and the hospital; changing the flow of nursing work; and improving the model of nursing management. Nursing reform in our hospital inspired the enthusiasm of the nursing personnel, enhanced the efficacy of nursing management and ensured nursing quality. [

Objective: To study the effect of seed oil of Hippophae rhamnoides L.(SOHR) on experimental hepatocirrhosis in mice. Methods: CCl_(4) was used in the experiment to form the model of experimental hepatocirrhosis in mice.In order to measure the possible changes of GPT and SOD in serum and SOD and MDA in tissues,we fed these mice with different concentration of SOHR for 45 days.The Does-Effect Curve was set up based on the data of this experiment. Results: SOHR could control the increase of GPT in serum and the decrease of SOD evidently,as well as the increase of MDA in tissues.The relationship of that the Hippophae rhamnoides dose with the decrease of GPT is significant. Conclusion: SOHR protects the experimental hepatacirrhosis in mice.

Objective The objective of this study was to determine the effect of curative chemotherapy regimen on breast cancer cells and its mechanism.Methods A tumor-bearing mouse model was established and routine dose of capecitabine was given as a conventional chemotherapy group.Continuous low-dose capecitabine chemotherapy was used as a radiotherapy group and no chemotherapy was used as a control group.The expression of microvessel density(MVD),vascular endothelial growth factor(VEGF)and thrombospondin 1(TSP-1)were measured by flow cytometry.The percentage of myeloid-derived suppressor cells(MDSCs),NK cells and macrophages in the program was observed.The tumor size and blood leukocyte count were measured after chemotherapy.Results MVD and VEGF in the radiotherapy group were significantly decreased and TSP-1 was significantly increased in comparison with the conventional chemotherapy group(P<0.05).The proportion of MDSCs in the radiotherapy group was significantly decreased,the proportion of NK cells and macrophages were significantly increased when compared to the conventional chemotherapy group(P<0.05).The tumor volume was no difference between the control and chemotherapy groups(P>0.05).However,the white blood cell count in the radiotherapy group was significantly higher than that in the conventional chemotherapy group(P<0.05).Conclusion Capecitabine chemotherapy at continuous low-dose inhibits neovascularization and adjusts the proportion of immune cells to suppress tumor formation.Thus,this chemotherapy could reduce side effects caused by chemotherapy and improve the quality of life.

Objective To investigate the clinical characteristics of juvenile rectal carcinoma in order to improve the diagnostic level and therapeutic efficacy at the early stage. Methods Clinical data, including clinical manifestations, misdiagnosis, clinical pathology, treatment, and prognosis, from 89 cases of juvenile rectal carcinoma were analyzed retrospectively and compared with those from 440 cases of senile rectal carcinoma. Results ① The main manifestations of juvenile rectal carcinoma included anal and rectal pains, abdominalgia, abdominal distention, and sacrococcygeal pain. ② In juvenile group, carcinomas with distance less than 9 cm and less than 7 cm away from the anal verge amounted to 92.13% and 69.66%, respectively (average distance: 5.43 cm). ③ The average period of misdiagnosis in juvenile group was 5.7 months with a misdiagnosis rate of 97.75%, significantly higher than that in senile group ( P

The extract content and in vitro releasing content from different processed products of Squama Manitis were determined using protein as index.The result indicates that the releasing rate of both pro- eessed products are obviously higher than that of the crude.The in vitro study on releasing rate of the same processed product shows that the dissolving rate in vitro has tight relation to its particle size.

The prevalence of prediabetes is increasing rapidly in China, and with higher prevalence in coronary heart disease and hypertension patients. Diabetes can be controlled and prevented, previous studies have confirmed that lifestyle interventions and drug interventions can delay the progression of prediabetes to diabetes, and acarbose can be used for the primary prevention of cardiovascular events in impaired glucose tolerance(IGT) and diabetic patients, but benefits of drug intervention for secondary prevention of cardiovascular disease in IGT population are uncertain. The Acarbose Cardiovascular Evaluation(ACE) Study is a multicentre, randomized, placebo-controlled, double-blind study, with the aim of assessing the use of acarbose to reduce the risk of cardiovascular events and the onset of diabetes in IGT patients with cardiovascular disease in China , the results will be very meaningful and valuable for the prevention and treatment of diabetes. We will predict the results of ACE Study based on previous evidences.

Objective To discuss the application of breast surgery with radical surgery in the therapeutic effect and complications in patients with early breast cancer.Methods 110 early breast cancer patients with surgical treatment were randomly divided into two groups,each group in 55 cases,the control group was given radical surgical treatment,the observation group was given breast conserving operation,surgery were recorded in patients of the two groups.Results The results of the observation group showed operative incision length (4.02 ±1.15)cm,operation time (58.93 ±13.25)min,intraoperative blood loss (10.11 ±2.87)mLand length of hospital stay (10.74 ±2.17)d. The datas of control group showed surgical incision length (11.87 ±2.44)cm,operation time (95.72 ±26.78)min, intraoperative blood loss (85.27 ±14.28)mL and length of hospital stay (15.86 ±4.43)d,the differences were statistically significant (t =21.582,9.131,5.714,7.697,all P <0.05).Observation group occurred postoperative hand infection in 1 case,upper extremity edema in 2 cases,and no subcutaneous hemorrhage occurs.Control group had 6 cases of postoperative hand infection,10 cases of upper limb edema,and subcutaneous hemorrhage in 5 cases,the differences were statistically significant (χ2 =4.852,5.986,5.238,all P <0.05).3 months after operation,datas of observation group showed physiological state (54.18 ±6.28)points,psychological state (59.27 ±5.82)points,environmental conditions (68.45 ±7.68)points and social function (57.46 ±5.97)points.Physiological state of the control group after 3 month was (65.69 ±9.11)points,while psychological state was (68.31 ±7.33)points,environmental conditions was (78.17 ±10.54)points,social function was (68.77 ±7.15)points,the differences were statistically significant (t =7.714,7.163,5.527,9.004,all P <0.05).Conclusion Breast surgery application in patients with early breast cancer can shorten the operation time,reduce intraoperative bleeding and flow rate,shorten the length of hospital stay, reduce complications and improve postoperative quality of life,it is worth popularizing in clinical application.

Objective To observe the effect of Chinese herbal compound Yitangkang on the expressions of advanced glyclation end-products (AGEs) and the receptor of advanced glyclation end-products mRNA(RAGE-mRNA) in rats with diabetic nephropathy(DN),and to discuss the mechanism of the formulas in the treatment of DN. Methods The rat model of DN were established by intraperitoneal injection of strepotozotocin(STZ). After 8 weeks intervention with medications, the expression of renal RAGEs mRNA was detected by Real-time PCR, renal RAGE by immunohistochemistry, and renal content of AGEs by spectrophotometry. Results Compared with normal control group, the expression of renal RAGEs mRNA and RAGEs in diabetic nephropathy rats were increased significantly(P<0.01). Compared with DN group, the expression of renal RAGEs mRNA and RAGEs in three doses Yitangkang groups and western medicine group were decreased significantly(P<0.01). Conclusion Chinese herbal compound Yitangkang could protect kidney of diabetic nephropathy rats,and the mechanism is related to its loweirng renal expression of RAGEs mRNA, RAGEs and AGEs content.

Objective To observe the biological characteristics and analyse primary therapeutic response of acute erythroid leukemia.Methods The data of 28 patients primarily diagnosed as acute erythroid leukemia were analyzed.The patients were divided into with muhilineage dysplasia group and without muhilineage dysplasia group,and the morphology,immunology,cytogenetics and molecular biology characteristics and the complete remission rate of the first induction therapy were compared.Results There were 14 cases(50％)with muhilineage dysplasia,which involved in two lineage or trilineage.In 6 cases by flow cytometry,the myeloid blast immunophenotypes were common expressed.In 8 cases detected by karyotype analysis,5 cases were chromosomal abnormal,including 4 cases were complex chromosomal abnormal,1 case was trisomy 8.In 4 cases underwent WT1 detection,all of them were positive.The complete remission rate of the first induction therapy was 39.29％(11/28),the ratein the multilineage dysplasia group was 35.71％(5/14),and the ratein without multilineage dysplasia group was 42.86％(6/14),the difference had no statistical significance(P＞0.05).The complete remission rate of the complex chromosome group was 25.00％(1/4),the intermediate prognostic group was 50.00％(2/4).Conclusions Acute erythroid leukemia had special biological features different from other subtype AML:accompanyed with high frequency of multilineage dysplasia.The abnormality of karyotype were high,and it was often complex karyotype involved with chromosome 5 and/or chromosome 7,which had a low complete remission rate.The complete remission rate of chemotherapy was low,treatment effect was poor.