Reading therapy in hospital libraries, academic libraries and public libraries was described in terms of its theoretical study and practical study,and its significance in hospital library was elaborated by comparative analysis.

Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.

Orthodontic tooth movement (OTM) is a very complicate mechano-biological procedure which is accomplished by the remodeling of periodontal tissues via orthodontic force.As the connective tissue between alveolar bone and cementum,periodontal ligament plays a vital role in the response and conduction of orthodontic force.The susceptible response of periodontal ligament to orthodontic force during OTM is a critical factor on inducing and modulating periodontal tissue restitution.This article reviews the concrete role of periodontal ligament and its mechano-biological behavior during OTM,discusses its mechanical response and biological mechanism respectively on histological,cellular and moleucular levels.

Objective:To investigate the clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema and evaluate the safety .Methods:Totally 96 cases of infantile with external ear eczema were ran-domly divided into the observation group (n=48) and the control group (n=48) according to a random number table .Both groups were given the conventional treatment .The control group was treated with topical compositus mentholi cream , while the observation group was treated with loratadine additionally .Both groups were treated for 10 d.The clinical efficacy , the level changes of interleukin-4 (IL-4), interferon-γ(IFN-γ) and immunoglobulin-E (IgE) before and after the treatment, the incidence of adverse reactions during the treatment and the relapse after 6-month follow-up were compared between the groups .Results:The total effective rate of the obser-vation group (95.83%) was significantly higher than that of the control group (79.17%, P<0.05); the levels of IL-4, IFN-γand IgE in both groups were significantly decreased after the treatment (P<0.05), and those in the observation group were significantly lower than those in the control group (P<0.05);there was no significant difference in the incidence of adverse reactions between the groups (P<0.05); the recurrence rate in the observation group (8.33%) was significantly lower than that in the control group (22.92%, P<0.05).Conclusion:The clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema is reliable with promising safety .

The WeChat service provided at present in 14 hospitals directly under the Yunnan Health and Family Planning Commission was surveyed with suggestions proposed for providing active Wechat service in hospitals in order to alleviate the difficulty to see a doctor and the tense relationship between doctors and patients.

Burns, Chemical ; Humans ; Phenols ; adverse effects

A total of 23 new cancer medicines or indication expansions were approved by the U. S. Food and Drug Administration in 2012. Among these, 12 are new molecular entities (NMEs)--new chemical or biological drugs approved for the first time for oncologic use--and 10 of these NMEs are molecular targeted agents. Among the 10 targeted agents, 4 are anti-angiogenesis agents and 2 are Bcr-Abl pathway inhibitors, targeting well established targets validated by previously approved agents such as bevacizumab (Avastin) or imatinib (Gleevec). Despite this progress, several questions remain: Do these newly approved agents provide sufficient treatment options to manage the broad spectrum of cancers we deal with in the clinic? Where will the next wave of new cancer drugs come from? Where should R&D efforts be invested to continue improve cancer treatment and management, especially for tumor types uniquely prevalent in China? This editorial and the review articles in this special issue of Chinese Journal of Cancer provide an in depth review of the progress and challenges in developing targeted cancer therapies, as well as an outlook of new research areas where near term breakthroughs are expected to overcome some of these challenges.
Angiogenesis Inhibitors ; therapeutic use ; Antineoplastic Agents ; therapeutic use ; China ; Drug Delivery Systems ; Drug Discovery ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Neoplasms ; therapy

Since cancer-related pain is the worldwide problem,intrathecal drug delivery system (IDD)has been an effective pain management option for patients with chronic and cancer pain.Compared with the other ways,such as oral or intravenous infusion,the delivery of drugs into the intrathecal space provides superior analgesia with lower doses of analgesics to minimize side effects while significantly improve quality of life.Recently,besides traditional opioid (especially mainly morphine) for intrathecal,clinical experts have also found some other drugs could be used for IDD to control the cancer-related pain,and have observed their effect and related adverses.This article aims to provide a general overview of the development trend in this field.

Objective To analyze the results of cervical cancer screening in 13 297 rural women in Gaoping during 2012-2015,and to explore more suitable way for rural women in the examination of cervical cancer.Methods According to theShanxi province rural women cervical cancer check project implementation plan,combined with the actual situation of Gaoping city,the gynecological examination of 13 297 married women in Gaoping city,vaginal and cervical secretions smear, cytology of cervical cytology ( TCT ) , to check the abnormal of the Department of Gynaecology and the abnormal cervical cytology, pathological examination of the cervix of the uterus with abnormal vaginal examination.Results A total of 6 965 cases of infection of the reproductive tract were examined, the prevalence rate was 52.38%.Among them,4 968 cases of cervicitis (37.36%),849 cases of trichomonas vaginitis (6.38%),Candida albicans vaginitis in 988 cases (7.43%),bacterial vaginal disease in 1 364 cases (10.26%), pelvic inflammatory disease in 1 348 cases (10.14%).Cervical cytology examination of ASC -US and the above cases in 418 cases (3.14%),ASC-US examination rate was 1.78%,the rate of ASC-H was 0.28%,the rate of LSIL was 0.60%,and the rate of HSIL was 0.47%.Detection of cervical precancerous lesions and cervical cancer cases,among them CIN I 81 cases,the incidence rate was 609.16/10 million,CIN II 29 cases,incidence rate was 218.09/10 million,16 cases of CIN,incidence rate was 120.33/10 million.The detection rate of precancerous lesions was 338.42/10 million.Cervical carcinoma in situ:1 case,9 cases of invasive cervical cancer,the detection rate of cervical cancer was 75.20/10 million.Conclusion Cervical cancer screening is helpful to improve the early detection rate of cervical cancer in rural women,safeguarding women's reproductive health.At the same time to carry out the census,vigorously promote health knowledge is also very important.

Objective To investigate the clinical effect of integrated care model in improving the quality of life and enthusiasm of treatment in patients with cardiovascular diseases. Methods 60 patients in department of cardiology adopting integrated care from September 2008 to April 2011 were chosen as the observation group.60 patients with ordinary care were set as the control group.The quality of life and the situation for enthusiasm of treatment were taken for statistical analysis. Results Patients with good quality of life in the observation group was 39 cases (65.00％),more than 21 cases (35.00％) in the control group.Patients obtaining effective treatment result in the observation group was 48 cases (80.00％) and 15 cases (25.00％) in the control group,there was significant difference.It was statistical significant.Adherence to medication,reasonable diet,adequate exercise and proper understanding of disease status in the observation group were significantly better than the control group. Conclusions Application of integrated care models in nursing of disease and life of patients with cardiovascular diseases can improve the quality of life and enthusiasm of treatment of patients,which is better than general model of care.