OBJECTIVE:To evaluate the cost-effectiveness of levofloxacin and sparfloxacin in the treatment of non?gonococcus urethritis(cervicitis)patients.METHODS:The clinical data of levofloxacin and sparfloxacin in the treatment of nongonococcus urethritis were collected with evidence-based medicine method and were evaluated with pharmacoeconomic cost-effectiveness analysis.RESULTS:The cure rates of two drugs were71.16%(62.00%,80.32%),81.69%(78.71%,85.21%)and cost-effectiveness ratios were2.29and2.71respectively.The?C/?E was5.57.CONCLUSION:The cost-ef?fectiveness ratio of levofloxacin was lower than that of sparfloxacin although the cure rate of sparfloxacin for nongonococcus urethritis was better.

0.05).The most common adverse reactions of imiquimod were erythema,erosion,itching,excoriation,scabbing and oedema,those of podophyllotoxin were burning sensation,inflammation,erosion,pain,itching and bleeding.The incidence of ADR of podophyllotoxin was higher.Cost-effectiveness analysis indicated that the C/E of imiquimod and podophyllotoxin was36.88and8.15respectively.CONCLUSION:Imiquimod and podophyllotoxin possessed similar curative effect on condylo?ma acuminatum,but the cost and C/E of podophyllotoxin were lower.At the same time,podophyllotoxin had more serious ad?verse reactions.

Objective To compare the clinical feature and cognitive function between patients with obsessive-compulsive disorder of different onset age and explore possible subtype.Methods 140 Patients with obsessive-compulsive disorder (OCD) were enrolled in test.All finished a series of tests including clinical feature,Trail-making test (TMT),Tower of Hanoi (TH) and Word fluency test (WFT).Patients were divided into two groups by onset age of 18.Results Compared with patients of onset age after18,patients of onset before18 were more with episode duration and more suicide attitude( x2 =4.214,x2 =11.542,P＜ 0.05 ).In TMT patients of onset before 18 had shorter time and little errors( (81.696 ±50.172)vs( 109.114 ±48.070),(1.169 ±2.983) vs ( 1.405 ± 2.020),P ＜ 0.05 ).Conclusion Obsessive-compulsive disorder with different onset age may be different type.

Animals ; Cattle ; Humans ; Infant ; Infant Formula ; Milk Hypersensitivity ; Milk Proteins ; adverse effects

Objective To investigate the factors relevant to the vascular calcification in uiemic patients.Methods Eighty-five uiemic patients were enrolled in this study.The levels of fetuin-A,serum calcium,serum phosphorus,C-reactive protein and other parameters related to calcification were examined.B-ultrasound was used to detect carotid plaques.Results The Fetuin-A levels in patients with vascular calcification were significantly lower than those with non-vascular calcification[(2.34±0.95) μg/L vs (3.79±1.19) μg/L,t=5.94,P＜0.01],but serum calcium,serum phosphorus and C-reactive protein were higher than those non-vascular calcification [serum phosphorus (1.97±0.23) mmol/L vs (1.80±0.33) mmol/L,t=2.05,P＜0.05;calcium and phosphorus product (50.04±6.61) mg~2/dl~2 vs (44.84±9.75) mg~2/dl~2,t=2.05,P＜0.05;C-reactive protein (33.45±25.11)mmol/L vs (20.65±13.43) mmol/L,t=2.03,P＜0.05].Linear correlation analysis indicated that low fetuin-A level was correlated with C-reactive protein (r=-0.43,P＜0.01),calcium-phosphorus product (r=-0.32,P＜0.01),serum albumin concentration (r=0.37,P＜0.05) and phosphorus level (r=-0.36,P＜0.05).Conclusions The risk factors relevant to the vascular calcification are high serum phosphorus,calcium and phosphorus product and the micro-inflammatory status in uiemic patients.Vascular calcification is also correlated with low fetuinA level,adding exogenous Fetuin-A may become an effective means in preventing vascular calcification.

Objective To review the recent studies about sentinel lymph node biopsy in breast cancer. Methods The literatures in recent years on the history, concept, technique and clinical application of sentinel lymph node biopsy were reviewed and summarized.Results There was no unified method for sentinel lymph node biopsy. There was a wide range of detection rate and false negative rate.Conclusion Prospective multi center random clinical trials will help to evaluate the clinical application of sentinel lymph node biopsy.

Objective To research the method for constructing an ECG acquisition platform on Zigbee based network with multi-node. Methods The platform is based on an SOC Zigbee chip CC2430. Furthermore,the hardware design and software ECG sampling process is introduced respectively. Results As the Zigbee can support dynamic routing on the platform,we can get ECG data in abundance,and meanwhile,users get more room and freedom. Conclusion It's a right nice scheme for colleting ECG data.

Objective Investigate the compatible stabilities of Sodium Glucuronic Acid Injection and Ganlixin Injection.Methods The Sodium Glucuronic Acid Injection mixed with Ganlixin Injection,to study the content of Sodium Glucuronic Acid Injection and Ganlixin Injection in different time by uv spectrophotometry,Investigate the appearance of the mixed solution,detect PH values and Insoluble Particles.Results At experimental temperature(15℃),the mixed solution,PH values,Insoluble Particles and the relative percentage have no obvious change in 4 hours.Conclusions The Sodium Glucuronic Acid Injection mixed with Ganlixin Injection is stabilization,so Sodium Glucuronic Acid Injection can combined with Ganlixin Injection.