4.Plasmacytoid-like oncocytic carcinoid of lung: report of a case.
Yongliang TENG ; Yabin ZOU ; Xu YAN ; Dianbo CAO ; Liang GUO
Chinese Journal of Pathology 2015;44(5):344-345
5.Atypical extraventricular neurocytoma: report of a case.
Yan LI ; Jing FU ; Yanke GUO ; Zhichao WANG
Chinese Journal of Pathology 2014;43(11):774-775
6.Primary intracranial mxyoid liposarcoma: report of a case.
Liang GUO ; Dian-bo CAO ; Xu YAN ; Ya-bin ZOU ; Hong-xi MA
Chinese Journal of Pathology 2013;42(12):843-844
7.Nemaline myopathy: report of a case.
Hong-ran WU ; Xing LIU ; Li-yan SUN ; Yi BU ; Yan-su GUO ; Dong-xia WU ; Xue-qin SONG
Chinese Journal of Pathology 2013;42(6):407-408
8.Temporal variation of serum interleukin-37 and its relation with C-reactive protein in patients with acute ST-segment elevation myocardial infarction.
Nvqin HE ; Shuxin SHEN ; Yan WANG ; Shengcun GUO ; Junfen WANG ; Jianping BIN
Journal of Southern Medical University 2015;35(12):1751-1754
OBJECTIVETo investigate the temporal changes of serum interleukin-37 (IL-37) concentration following acute ST-segment elevation myocardial infarction (ASTEMI) and the relationship between IL-37 and C-reactive protein (CRP) in patients with ASTEMI.
METHODSThis analysis was conducted in a cohort of 20 patients with an established diagnosis of ASTEMI and 26 patients admitted for chest pain but with normal findings in coronary angiography (control) between June 2012 and December 2013. Venous blood was collected at days 1, 3, 5, and 7 after myocardial infarction for measurement of serum IL-37 and CRP levels using enzyme-linked immunosorbent assay (ELISA).
RESULTSCompared with the control group, the patients in ASTEMI group showed a significant acute elevation of IL-37 level on day 1 following myocardial infarction; IL-37 level reached the peak on day 3 and began to decrease on day 5, followed by a significant decrease on day 7. The time course of post-infarction CRP changes was consistent with that of IL-37 variations and showed a positive correlation the latter (r=0.63, P<0.05).
CONCLUSIONIL-37 may participate in the inflammatory responses in ASTEMI.
C-Reactive Protein ; metabolism ; Coronary Angiography ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukin-1 ; blood ; Myocardial Infarction ; blood
9.Supra-molecular assembly and magnetic targeted slow-release effect of "dextran-magnetic layered double hydroxide-fluorouracil" drug delivery system.
Guo-jing GOU ; Yan-hong LIU ; Yue SUN ; Je HUANG ; Bing XUE ; Li-e DONG
Acta Pharmaceutica Sinica 2011;46(11):1390-1398
The drug-loading system of DMF (dextran - magnetic layered double hydroxide - fluorouracil) was synthesized by "co-precipitation intercalated assembly - dextran composite in situ - solvent conversion" technology. The crystal-phase characteristic and slow-release performance of DMF were investigated through X-ray diffraction (XRD), infrared spectrum (IR), transmission electron microscopy (TEM), thermogravimetry (TG) and in vitro release experiment. The targeted transshipment and slow-release effect of DMF system were evaluated by in vivo animal experiment. It was showed that the XRD of DMF matched with R-sixtetragonum type layered double hydroxide and Fd-3m cubic type ferrite. IR test demonstrated that the DMF system was a supra-molecular complex consisted of Dextran (DET), magnetic layered double hydroxide (MLDH) and fluorouracil (FU) components. The two-level supra-molecular MLDH-FU presented six-edge lozenge TEM morphology, with layered characteristics. DET on the surface of DMF was capable of protecting the layered structure of MLDH-FU, improving particle dispersion properties, and strengthening the slow-release performance of the drug delivery system. The drug release model of DMF at pH 7.35 of PBS in vitro fit to the zero-order kinetics equation C = 1.1716 x 10(-5) + 4.4626 x 10(-7) t. The drug delivery system DMF could transport drugs principally to in vivo target organs with a local effect, targeted specificity, and excellent circulation transshipment performance. The pharmacokinetic process of DMF presented multi-peak phenomenon with peak attenuation and cyclic growth. The peaks appeared at 0.25, 1, 3, 5 and 9 d separately after dosing intervention. The first peak process of DMF accorded with a pharmacokinetic equation of C(FU) = 14.34 e(-0.530t) + 36.04 e(-0.321t) + 24.18 e(-0.96t), and presented the characteristic of slow absorption and fast elimination. As for subsequent peak processes, half-life increased, bioavailability increased, and plasma clearance decreased. The highest peak value of DMF was 1/37 of original value of FU, and the relative bioavailability was 419% to original FU.
Animals
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Biological Availability
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Delayed-Action Preparations
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Dextrans
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chemistry
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Drug Carriers
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Female
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Fluorouracil
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administration & dosage
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chemistry
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pharmacokinetics
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Half-Life
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Hydroxides
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chemistry
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Magnetics
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Male
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Microscopy, Electron, Transmission
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Rats
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Rats, Sprague-Dawley
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Spectrophotometry, Infrared
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Thermogravimetry
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X-Ray Diffraction
10.Roles of calcitonin gene-related peptide family in pain and opioid tolerance.
Acta Physiologica Sinica 2013;65(3):347-354
The calcitonin gene-related peptide (CGRP) family mainly includes CGRPα, CGRPβ, adrenomedullin, calcitonin and amylin. The members of CGRP family and their receptors are widely distributed in the central and peripheral nervous systems. Studies show that members of CGRP family such as CGRP and adrenomedullin play important roles in the transmission of nociceptive information. At spinal level, CGRP promotes the transmission of nociceptive information, spinal morphine tolerance, migraine, inflammatory pain and neuropathic pain. At superspinal level, CGRP suppresses the transmission of nociceptive information. Adrenomedullin is a pain-related neuropeptide which has recently been demonstrated. It facilitates the transmission of nociceptive information and is involved in the development and maintenance of opioid tolerance. The involvement of amylin and calcitonin in pain is not clear yet.
Adrenomedullin
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physiology
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Analgesics, Opioid
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pharmacology
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Animals
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Calcitonin Gene-Related Peptide
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physiology
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Drug Tolerance
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Humans
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Islet Amyloid Polypeptide
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physiology
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Nociception
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Pain
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physiopathology