2.Establishment of uterine leiomyoma in animal model
Chinese Pharmacological Bulletin 1987;0(03):-
Aim To establish an animal model of uterine leiomyoma for pathogenesis research and drug screen analysis.Methods Guinea pigs were treated with estradiol benzoate 100 ?g?d~(-1),twice a week,by intramuscular injection for 12 weeks.After the animal were killed,the uteri were dissected out and ultrathin sections were obtained.Compare to that of human being,pathohistologic characteristics were observed under the microscope.Results The uteri treated with estrogen were proliferated and deformated.Uterine nodules were observed in many of the tested animals.According to the results of pathohistology,these cells demonstrate the features of smooth muscle-like cells.Conclusion The uterine leiomyoma induced by estrodiol in guinea pig is similar to that of human being.It has been suggested that the animal model is valuable for pathogenesis research and drug screen analysis,although it still needs more evidence to be demonstrated.
3.Clinical progress in treatment of HER2 positive breast cancer with trastuzumab
Journal of International Oncology 2010;37(8):593-596
Clinical studies have shown that trastuzumab combined with chemotherapy can significantly improve survival in treatment of HER2-positive metastatic breast cancer as well as in the neoadjuvant and adjuvant therapy for HER2-positive early breast cancer. In patients with HER2-positive and hormone receptor-positive metastatic breast cancer, adding trastuzumab to endocrine therapy improves treatment efficacy. Resistance to trastuzumab may be reversed by incorporating other targeted therapeutic drugs. Patients can still benefit from continuing trastuzumab after their disease progresses.
4.Mr. Zhu Xiankang’s Experience in Treating Children Multiple Tourette Syndrome
Journal of Zhejiang Chinese Medical University 2014;(1):58-60
[Objective]To sum up Mr. Zhu Xiankang’s clinical experience in treating children multiple tourette syndrome with nourishing kidney to soothe liver and relieving dizziness to remove sputum. [Method] By expounding the reason and mechanism, treating rules and formula of children multiple tourette syndrome, as wel as analyzing typical clinical cases, it expounds Pro. Zhu Xiankang ’s experience in treating the said disease with his method. [Re-sult] In his view, the disease owes to excessive five sensations, wind sputum accumulated inside, with mechanism of deficient kidney and hyperactivity of liver, wind sputum blocking col aterals, should take nourishing kidney to soothe liver and relieving dizziness to remove sputum as basic method;he applied revised Dingchou Decoction to treat 1 case of multiple tourette syndrome; after 3m, the un-automomous spasm disappeared gradual y, the patient had good appetite and sleep, al symptoms were relieved, and he was cured. [Conclusion] Mr. Zhu Xiankang ’s clinical experience in treating children multiple tourette syndrome has enlightenment to pediatrics clinic.
5.Gene therapy and cutaneous wound healing
International Journal of Surgery 2009;36(4):281-284
Cutaneous wound healing is a complicated multiatep process with numerous mediators that act in a network of activation and inhibition processes. Nonhealing chronic wounds decrease the quality of Life. Recombinant growth factors, currently used in clinic, fail to provide a sustained repair function at the wound due to their inadequate biological availability and transient half-time. Recent attention has focused on gene therapy, which might become a significant treatment modality for those wound healing pathologies refractory to other wound management approaches. This review discusses the potentials and limitations of current genetherapy for the treatment of wounds, current ongoing clinical trials, and possible future directions in this exciting field.
6.Research Progress in Prevention and Treatment of Postoperative Abdominal Adhesions by Ligustrazine
World Science and Technology-Modernization of Traditional Chinese Medicine 2015;(6):1290-1294
Ligustrazine is one of the active ingredients of chuanxiong. Modern medical research indicated that ligustrazine had the effect of improving microcirculation, anti-inflammatory, anti-fibrosis, which showed the potential function of ligustrazine in the prevention and treatment of postoperative abdominal adhesions. The basic theory of traditional Chinese medicine (TCM) also believed that ligustrazine had the unique double effect of regulating both qi and blood. Therefore, ligustrazin had broad research and application prospects in the prevention and treatment of postoperative abdominal adhesions. This article reviewed studies of ligustrazine in the prevention and treatment of postoperative abdominal adhesions in recent years from four aspects, which were theoretical basis, clinical application, mechanism research and pharmaceutical dosage forms. It identified the research status and advantages of ligustrazine in the prevention and treatment of postoperative abdominal adhesions. It also pointed out shortages in the clinical application, such as unstandardized medication, small sample size study and etc. There were insufficient deep and clear studies in the research of mechanism. In the aspect of pharmaceutical dosage forms, the thinking should be expanded with innovation. It will provide basis and direction for research and application in the future, in order to further elucidate mechanisms in the prevention and treatment of postoperative abdominal adhesions as well as provide theory basis, research thinking and methods for the real display of advantages in TCM.
7.Research progress on abnormal fatty acid metabolism in cancer cells
Chinese Journal of Clinical Oncology 2015;(5):313-316
Cancer cells frequently share biological characteristics and energy metabolic processes distinct from normal cells. The specific metabolic phenotype was originally known as the Warburg effect. Researchers later discovered that cancer cells prefer to synthesize fatty acid de novo . Moreover, key enzymes involved in fatty acid synthesis and β-oxidation are overexpressed in tumor tissues, with low or without expression in normal tissues. Abnormal fatty acid metabolism is related to the survival and invasiveness of cancer cells, indicating that abnormal fatty acid metabolism provides the crucial components and energy sources of cancer cells. In recent years, the specific phenotype of abnormal fatty acid metabolism and the exploration of the role of this metabolic alteration in cancer biology and therapeutic strategies targeting the fatty acid metabolic pathways have become attractive focuses in cancer research. The role of active fatty acid metabolism in tumorigenesis and development, as well as the research progress in the development of the specific inhibitors, is reviewed in this paper.
8.Design of enzyme immunoassay instrument
Chinese Medical Equipment Journal 2004;0(08):-
The incretion secretion metrical technique is the important embranchment in clinical diagnosis presently,in which the magnetic separate enzyme immunoassay is the main technique.This paper introduces the principle and design of Chinese enzyme immunoassay instrument,and emphatically discusses the design of nonlinear data processing model.
9.Relationship between low birth weight and kidney diseases
International Journal of Pediatrics 2016;43(9):707-710
Newborn due to low birth weight caused by preterm or fetal growth restriction will have an adverse effect on kidney development. In adulthood,the long-term adverse effects of low birth weight are associ-ated with a variety of kidney disease. Current studies suggest that low birth weight may participate in a variety of kidney disease development and progression by affecting the nephron number,the function of the vascular struc-ture and the endocrine level. This paper mainly reviews the relationship between low birth weight and kidney dis-ease.
10.Mechanisms of nuclear receptors in gallstone formation
International Journal of Surgery 2016;43(7):499-502
Gallstone disease is highly prevalent in clinic,particularly in women and some specific ethnic groups.The formation of water-insoluble cholesterol crystals is due to a misbalance between the three major lipids present in the bile:cholesterol,bile salts,and phospholipids.Many proteins implicated in biliary lipid secretion in the liver are regulated by several transcription factors,including nuclear receptors LXR and FXR.Human and murine genetic,pathophysiological evidence is consistent with the relevance of these nuclear receptors in gallstone formation.In addition,there is emerging data that also suggests a role for estrogen receptor ESR1 in abnormal cholesterol metabolism leading to gallstone disease.A better comprehension of the role of nuclear receptor function in gallstone formation may help doctors to design new and more effective therapeutic strategies for this highly prevalent disease condition.