The molecular mechanisms of breast cancer metastasis still remain unclear.Recent studies have found that zinc finger protein plays critical roles in determining tumor formation,occurrence,development and metastasis.This review summarized the functions of zinc finger protein in breast cancer metastasis.

Objective To explore the short-term efficacy and side effects of recombinant human interferon α-2b (rhIFNα-2b) combined with adefovir dipivoxil in the treatment of chronic hepatitis B (HBeAg +).Methods 174 patients with chronic hepatitis B were randomly divided into three groups.60 patients in group A were given rhIFNα-2b and adefovir dipivoil.57 patients in group B were only given rhIFNα-2b.57 patients in group C were only given adefovir dipivoil.After treatment for 48 weeks,the changes of liver function and HBVM were observed in three groups.Results ALT was significantly decreased in three groups.But group A was obviously higher than group B and group C(P ＜ 0.05).The negative rate of HbeAg was 48.3％,36.8％ and 33.3％.The negative rate of HBV-DNA was 63.3％,42.1％ and 40.4％.The effect of group A was better than that of group B and group C(P ＜0.05).Side effects had not been found.Conclusion rhIFNα-2b combined with adefovir dipivoil can improve liver function and inhibit HBV.

Objective To investigate the clinical diagnosis and treatment value of hysteroscopy on patients with abnormal uterine bleeding.Method 60 patients with abnormal uterine bleeding were taken hypsteropic diagnosis and treatment compared with B ultrasonic and histologic diagnosis.The confirmed cases also taken hysteroscopy surgery.Results Endometrial polyps 23 cases (38.3％),endometrial hyperplasia disease 17 cases (28.3％),submucous myoma of uterus 9 cases (15.0％),uterine cavity adhesion in 7 patients (11.7％),submucosal uterine adenomyoma 2 cases (3.3％),chronic endometritis 1 case (1.7％) and endometrial carcinoma 1 case (1.7％) respectively.The concordance rate of B ultrasonic diagnosis and histologic diagnosis was 40.0％,while rate of hypsteropic diagnosis and histologic diagnosis was 86.7％,the difference was significant (x2 =0.865,P ＜ 0.001).In 60 patients,the cure rate of hysteroscopy surgery was 98.3％.Conclusion Hysteroscopy in gynecological abnormal uterine bleeding diagnosis is specific,while the treatment effect is remarkable,which can be used as a safe and effective method to diagnosis and treatment abnormal uterine bleeding.

Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and carotid plaque stability.Methods 155 cases confirmed cerebral infarction by head CT/MRI were divided into group without plaque,plaque vulnerability group and plaque stability group.Serum levels of hs-CRP,lipids,creatinine and uric acid were measured.Results Logistic regression analysis was used to analyze the parameters of all the patients'age,serum TC,LDL-C,HDL and HDL-C,serum creatinine,hs-CRP and uric acid.Only hs-CRP level was the risk factor of carotid plaque(RR =1.301,95％ CI =1.041 ～ 1.599,P =0.010).Serum hs-CRP level in patients with vulnerable plaque was significantly higher than the group without plaque and plaque stability group.Conclusion The detection of serum hs-CRP and carotid artery ultrasound can make early diagnosis and intervention to reduce the incidence and mortality of cerebral infarction for plaque instability patients.

Objective To investigate the clinical efficacy of nursing interventions on leukemia patients with fever caused by perianal infection during bone marrow suppression stage.Methods 78 leukemia patients during bone marrow suppression stage were divided into the observation group and the control group.Pertinent integrated care intervention was taken in the observation group,while routine nursing care was taken in the control group.The infection rate was compared between the two groups.Results The rate of perianal infection in the control group was 30.77％,higher than 5.13％ of the intervention group.Conclusions Leukemia patients during bone marrow suppression stage have low immunity and are easily to occur perianal infection.Pertinent integrated care intervention can obviously decrease infection rate and improve their life quality.

OBJECTIVE:To facilitate a smooth evolvement of the classified drug control in China.METHODS:The de-velopment of Chinese classified drug control was reviewed and problems in the process of its enforcement were discussed.RES_ ULTS&CONCLUSION:The related laws,codes and policies should be established as soon as possible,and the knowledge of safe drug use should be popularized among the public to facilitate evermore smooth classified drug control.

Objective To detect the expression of aquaporins-8 ( AQP-8 ) in placenta and fetal membrane tissue of pregnant women with hypertensive disorders ,and to explore the role of AQP-8 in the pathogenesis of gesta-tional hypertension .Methods 81 term pregnant women with cesarean section were selected ( including 25 cases hypertensive disorders complicating pregnancy,26 cases with preeclampsia,30 cases with normal pregnancy),immu-nohistochemical method was used to detect AQP-8 expression in placenta ,fetal membranes tissue of those 3 groups. Results AQP-8 protein expressed in placenta ,fetal membranes of pregnant women in 3 groups.Mainly in epithelial cells of the amnion , chorionic trophoblast nucleus , syncytiotrophoblast membrane and cytoplasm of placenta .The expression levels of AQP-8 in the amnion of the control group , hypertension group and preeclampsia group were (4.78 ±2.05),(5.45 ±2.08),(6.18 ±2.15),respectively.Those levels in the chorion of three groups were (4.16 ±2.13),(5.04 ±1.92),(5.59 ±2.39),respectively.Those levels in the placenta of three groups were (5.62 ±2.16),(6.01 ±2.30),(7.61 ±2.71),respectively.Expression of AQP-8 protein was gradually increased , and had statistical differences in different places (F=3.121,3.148,5.785,P=0.049,0.048,0.005).The difference of AQP-8 protein expression in amnion of normal group and preeclampsia group was statistically significant (t=2.01, P=0.016).Conclusion Expression of AQP8 protein in placenta and fetal membranes of pregnant women with hypertensive disorder was significantly increased ,and was associated with severity of disease ,it might be involved in the occurrence and development of gestational hypertension .

Cervical artery dissection (CeAD) is an important cause of ischemic stroke in young adults w ith ischemic stroke. The clinical manifestations are often local facial pain, Horner syndrome, and ischemic stroke. With the development of noninvasive imaging, many patients w ith CeAD have got early diagnosis. Thromboembolism is an important mechanism of its pathogenesis. Timely giving anticoagulation therapy is reasonable. How ever, anticoagulants may lead to intramural hematoma expansion; therefore, there are also people w ho support antiplatelet therapy. How ever, the effectiveness of the 2 regimens needs to be confirmed by randomized trials. The recently completed Cervical Artery Dissection in Stroke Study (CADISS) in patients w ith stroke is the first prospective study aiming at the problem. The results have show ed that there w as no significant difference in efficacy betw een the anticoagulants and the antiplatelet drugs. Thrombolysis in patients w ith acute CeAD can not increase the risks of hemorrhage, and the rate of good functional outcome is similar to that of the control group. Therefore, it can be used as a treatment method in acute phase. For patients w hose antithrombotic treatment is invalid or having contraindications and repeated recurrent stroke can conduct endovascular intervention or surgical treatment. Usualy, the prognosis of patients w ith CeAD is better. The stroke recurrence rate is low . The abnormal arterial w als in more than half of the patients w il disappear at 3 to 6 months.

Adult ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Estrogens ; therapeutic use ; Female ; Humans ; Phytotherapy ; Primary Ovarian Insufficiency ; drug therapy ; Progesterone ; therapeutic use