Reading therapy in hospital libraries, academic libraries and public libraries was described in terms of its theoretical study and practical study,and its significance in hospital library was elaborated by comparative analysis.

Orthodontic tooth movement (OTM) is a very complicate mechano-biological procedure which is accomplished by the remodeling of periodontal tissues via orthodontic force.As the connective tissue between alveolar bone and cementum,periodontal ligament plays a vital role in the response and conduction of orthodontic force.The susceptible response of periodontal ligament to orthodontic force during OTM is a critical factor on inducing and modulating periodontal tissue restitution.This article reviews the concrete role of periodontal ligament and its mechano-biological behavior during OTM,discusses its mechanical response and biological mechanism respectively on histological,cellular and moleucular levels.

Objective:To investigate the clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema and evaluate the safety .Methods:Totally 96 cases of infantile with external ear eczema were ran-domly divided into the observation group (n=48) and the control group (n=48) according to a random number table .Both groups were given the conventional treatment .The control group was treated with topical compositus mentholi cream , while the observation group was treated with loratadine additionally .Both groups were treated for 10 d.The clinical efficacy , the level changes of interleukin-4 (IL-4), interferon-γ(IFN-γ) and immunoglobulin-E (IgE) before and after the treatment, the incidence of adverse reactions during the treatment and the relapse after 6-month follow-up were compared between the groups .Results:The total effective rate of the obser-vation group (95.83%) was significantly higher than that of the control group (79.17%, P<0.05); the levels of IL-4, IFN-γand IgE in both groups were significantly decreased after the treatment (P<0.05), and those in the observation group were significantly lower than those in the control group (P<0.05);there was no significant difference in the incidence of adverse reactions between the groups (P<0.05); the recurrence rate in the observation group (8.33%) was significantly lower than that in the control group (22.92%, P<0.05).Conclusion:The clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema is reliable with promising safety .

The WeChat service provided at present in 14 hospitals directly under the Yunnan Health and Family Planning Commission was surveyed with suggestions proposed for providing active Wechat service in hospitals in order to alleviate the difficulty to see a doctor and the tense relationship between doctors and patients.

Objective If IL-2 and IFN-? are united,perhaps we may see a more significant antitumor effect.A fusion gene of IL-2 and IFN-? was designed and constructed by DNA engineering.Methods CEA promotor、IL-2cDNA and IFN-?cDNA were obtained by PCR and RT-PCR.SDS-PAGE was used to examine the results;pcDNA-IL-2、pcDNA-IFN-?、pCEA-IL-2/ IFN-?、pEGFP-IL-2/ IFN-? were transfected to CEA high expression cell line(Lovo)by use of liposome.The fusion protein expression was examined by fluorescence microscope and Western blotting.Results IL-2/ IFN-? fusion gene can be expressed in tumor cells.Its expression is more obvious in CEA high expressed cells(Lovo),and can be located in cell plasma.Conclusion The fusion gene can be expressed in plasma of CEA high expressed cell lines.It may have a new anti-tumor effects.

ObjectiveTo explore the effect of different nursing models to improve the quality of sleep for elderly patients in department of cardiology.Methods240 cases of patients in department of cardiology in our hospital were randomly divided into the control group and the observation group with 120 patients in each group.The control group was given conventional medical care and the sleep-related health education.While the observation group was given the targeted intervention measures based on the control group,including the provision of good psychological care measures to ensure a good sleep environment,arrange a reasonable sleep time,increase bedtime benign behavior and scientific education of hypnotic drugs knowledge.The PSQI score and sleep quality of different time points were compared.ResultsThe PSQI score of the observation group 1 week and 2 weeks after admission was significantly decreased compared with that upon admission,and was better than those of the control group.The PSQI score of the control group 2 weeks after admission had a marked decline,but the PSQI score 1 week after admission showed no significant difference.In the aspect of sleep quality,the rate of good sleep quality for the observation group 1 week and 2 weeks after admission increased significantly compared with that upon admission.The rate of the quality of good sleep 2 weeks after admission for the control group improved significantly than admission.The rate of promotion for the observation group was obviously better than that of the control group.ConclusionsThe targeted quality of sleep and psychological care interventions for elderly patients in department of cardiology can significantly improve the sleep quality in patients after admission,and enhance their confidence in overcoming the disease,thus contribute to disease treatment and rehabilitation.

0.05).CONCLUSION:4-paramisan sodium oral colon-specific delivery coated tablets coated in turn with permeable and enteric soluble acrylic resin has ideal specific delivery and slow-release properties,the coating technology was stable and the reproducibility is good.

Burns, Chemical ; Humans ; Phenols ; adverse effects

A total of 23 new cancer medicines or indication expansions were approved by the U. S. Food and Drug Administration in 2012. Among these, 12 are new molecular entities (NMEs)--new chemical or biological drugs approved for the first time for oncologic use--and 10 of these NMEs are molecular targeted agents. Among the 10 targeted agents, 4 are anti-angiogenesis agents and 2 are Bcr-Abl pathway inhibitors, targeting well established targets validated by previously approved agents such as bevacizumab (Avastin) or imatinib (Gleevec). Despite this progress, several questions remain: Do these newly approved agents provide sufficient treatment options to manage the broad spectrum of cancers we deal with in the clinic? Where will the next wave of new cancer drugs come from? Where should R&D efforts be invested to continue improve cancer treatment and management, especially for tumor types uniquely prevalent in China? This editorial and the review articles in this special issue of Chinese Journal of Cancer provide an in depth review of the progress and challenges in developing targeted cancer therapies, as well as an outlook of new research areas where near term breakthroughs are expected to overcome some of these challenges.
Angiogenesis Inhibitors ; therapeutic use ; Antineoplastic Agents ; therapeutic use ; China ; Drug Delivery Systems ; Drug Discovery ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Neoplasms ; therapy

Objective To study the correlation of blood uric acid,lipoprotein associated phospholipase A2(Lp-PLA2) and arterial stiffness in young patients with coronary heart disease.Methods 56 young patients with coronary heart disease were selected as the observation group,50 young healthy subjects were selected as control group.The serum uric acid,Lp-PLA2 and arterial stiffness in the two groups were determined.Blood uric acid,Lp-PLA2 and arterial stiffness in patients with coronary heart disease were analyzed.Results There were no significant differences in age,sex,BMI,systolic blood pressure,diastolic blood pressure and triglyceride between the two groups (all P>0.05).The total cholesterol,low density lipoprotein,uric acid and Lp-PLA2 in the observation group were significantly higher than those in the control group (t=3.927 4,4.162 4,5.772 6,9.770 1,P<0.05,P<0.01).High density lipoprotein in the observation group was significantly lower than that in the control group (t=2.6043,P<0.05).Multivariate Logistic regression analysis showed that low density lipoprotein cholesterol,uric acid,Lp-PLA2 were independent risk factors for coronary heart disease (low density lipoprotein uric acid OR=1.053,95% CI:1.031-1.106;uric acid OR=1.082,95% CI:1.043-1.115;Lp-PLA2 OR=1.007,95% CI:1.002-1.011).The arterial stiffness of the observation group was (8.86±1.63)v·cm-1·s-1,and had positive correlation with serum uric acid (r=0.221,P<0.05) and Lp-PLA2 (r=0.361,P<0.05).Conclusion Blood uric acid,Lp-PLA2 can reflect the early arterial stiffness in young patients with coronary heart disease.