Objective To explore the main risk factors of diabetic nephropathy (DN) and to evaluate the quality of life in patients with type 2 diabetes mellitus (T2DM) in Huizhou area. Methods The data of T2DM patients who were hospitalized and revisited in XX hospital in Huizhou from January 2, 2017 to February 20, 2020 were selected, and those who met the diagnostic criteria were included in the study, and their general data were investigated and analyzed. According to the clinical data, 347 patients were divided into simple T2DM group, early DN group and clinical DN group. The differences in the clinical characteristics among the different groups were compared and the risk factors related to DN in T2DM patients were analyzed. The quality of life of patients was assessed. Results Among the 347 patients, T2DM alone accounted for 57.93%. There were 146 DN patients, accounting for 42.07% of the total. Analysis of the clinical data showed that there were significant differences in age, course of disease, waist circumference, history of hypertension, and weekly physical exercise time among the three groups (P<0.05). In addition, the differences in age, course of disease, and history of hypertension were statistically significant between the clinical DN group and other two groups (P<0.05). Age, physical exercise time less than 3h/week, and increased course of T2DM were all risk factors related to DN in T2DM patients. The quality of life of patients in the T2DM group was the highest, and the quality of life in the clinical DN group was the worst (P<0.05). Conclusion The prevalence of DN in T2DM patients in Huizhou is 42.07%. Age, physical exercise time, and course of disease are risk factors related to DN. The quality of life of DN patients is poor.

The poor prognosis of triple negative breast cancer (TNBC) results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis, which is associated with high recurrence and short overall survival. Here we developed a strategy by employing tumor-targeted self-assembled nanoparticles to coordinately regulate BACH1 (BTB domain and CNC homology 1) and mitochondrial metabolism. The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative (BD) were used to prepare nanoparticles (BH NPs) followed by the modification of chondroitin sulfate (CS) on the surface of BH NPs to achieve tumor targeting (CS/BH NPs). CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites, glycolysis and metastasis-associated proteins, which were related to the inhibition of BACH1 function. Meanwhile, decreased mitochondrial membrane potential, activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism. In a xenograft mice model of breast cancer, CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs. In sum, the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC.

[This corrects the article DOI: 10.1016/j.apsb.2022.06.009.].