OBJECTIVE:To optimize the formulation and preparation technic of azathioprine liposomes and evaluation the quality.METHODS:The liposomes were prepared by a film-vibration technique.The optimal formulation and preparation technic were selected by means of an orthogonal design test.The entrapment ratio of liposomes was studied by titrimetric method.The size distribution and appearance of liposomes were observed under microscope.RESULTS:The entrapment ratio of azathioprine liposomes was49.19%.The liposomes consisted of spherical or similar to spherical multilamellar vesicles with78.17%of particles in the liposomes smaller than2.4?m.CONCLUSION:The selected formulation and preparation technic of azathioprine liposomes are rational and stable.

OBJECTIVE:To investigate the characteristics of pharmaceutical care for critical patients with multi-drug resistant Acinetobacter baumanni infection.METHODS:Retrospective analysis was applied to analyze the distribution of pathogenic bacteria,drug resistance,therapeutic results and pharmaceutical care in 36 critical patients with multi-drug resistant Acinetobacter baumanni infection.RESULTS:Multi-drug resistant Acinetobacter baumannii had severe drug resistance to antibiotics.It is difficult for critical patients to treat Acinetobacter baumannii infection after infection.CONCLUSION:Clinical pharmacist should be engage in clinical practice,give full play to their clinical expertise and enhance pharmaceutical care.It is very important for prevention of multi-drug resistant strains and appropriate use of drugs that clinical pharmacist be involved in formulating therapeutic regimes for multi-drug resistant Acinetobacter baumannii infection and strengthen pharmaceutical care.

OBJECTIVE:To study the pharmacoeconomic effectiveness of three antihyperlipoidemics METHODS:According to literature reports,158 patients with hyperlipoidemia were selected These patients were randomly divided into three groups which received zhibituo,pravastatin and simvastatin respectively The results were evaluated with pharmacoeconomic analysis RESULTS & CONCLUSION:The cost of zhibituo is minimal

OBJECTIVE:To explore the risk factors for nosocomial infection of multidrug-resistant organism (MDRO) in ICU,and to provide reference for preventing and controlling MDRO in ICU. METHODS:In retrospective study,246 patients with nosocomial infection from ICU of Xi'an Aerospace General Hospital (hereinafter referred to asour hospital) during Jan. 2011-Dec. 2015 were selected and divided into non-MDRO infection group (140 cases) and MDRO infection group (106 cases). The detection and drug resistance of MDRO were analyzed in MDRO group. Univariate analysis and binary Logistic regression anal-ysis were used to explore risk factors for nosocomial infection of MDRO. RESULTS:During 2011-2015,435 strains of MDRO were isolated from 106 MDRO infection patients,in which Gram-negative bacteria accounted for 89.43%,showing severe drug re-sistance. Univariate analysis showed that the following 13 factors were related to nosocomial infection of MDRO,such as ICU ad-mission time,hypoproteinemia,acute cerebrovascular diseases,renal abnormalities,mechanical ventilation time,arterivenous cath-eterization time,urethral catheterization time,indwelling gastric tube time,type and time of using antibiotics,combined use of an-tibiotics,application of carbapenems and the third generation caphalosporins(P<0.05). Binary Logistic regression analysis showed that acute cerebrovascular diseases,type and time of using antibiotics were the independent risk factors for nosocomial infection of MDRO in ICU [odds ratios were 2.816,1.582,1.265,95%CI were (1.540,5.151),(1.085,2.306),(1.131,1.415)]. CONCLU-SIONS:Some prevention and control measures should be taken actively for high-risk MDRO infection patients in ICU to reduce the incidence of nosocomial infection of MDRO and improve the quality of health care.

OBJECTIVE:To establish the quality standard for Xiaoer Zhike oral liquid(XZOL).METHODS:The Herba Ephedrae,Pericarpium Citri Reticulatae and Radix Glycyrrhizae in XZOL were identified by TLC.The chlorogenic acid in the liquid was determined by HPLC,The mobile phase was methanol-water(10∶90)with a flow rate of1ml/min,the detection wavelength was254nm.RESULTS:The Herba Ephedrae,Pericarpium Citri Reticulatae and Radix Glycyrrhizae in XZOL could be identified on TLC chromatograms.The linear range of chlorogenic acid was0.2?g～1.2?g(r=0.9996),the average recov?ery was96.67%,RSD was1.04%.CONCLUSION:The method is simple,reliable and accurate.The method can be used for quality control of XZOL.

OBJECTIVE: To develope a reversed-phase high performance liquid chromatographic(RP-HPLC) method for the determination of allitridum in human serum.METHODS: The serum sample was injected after being deproteinized with trichloroaceticacid and being extracted with hexane.A Phenomenex C1s was used as the stationary phase and the solution being composed of acetonitrile- 1%HAc(62: 38,V/V)as the mobile phase with a flow rate of 1.2 ml/min .The serum samples were monitored at 240nm.RESULTS: The peak area of allitridum against allitridum concentration was linear with a correlation coefficient of 0.9 977 over the range of 0.29～12.4 μg/ml, the limitation of detection was 0.18 μg/ml.The average recovery was (99.2 ± 6.6) %, within - day RSD＜ 5.5% (n = 5), between - day RSD＜ 5.8% (n = 5) .CONCLUSIONS: This method is rapid, accurate and sensitive,it is very suitable for the investigation on clinical pharmacokinetics of allitridum.

OBJECTIVE:To compare the pharmacoeconomic effectiveness of three antiviral agents for herpes zoster ME_THODS:101 patients with herpes zoster were divided into three groups who received acyclovir injection,valaciclovir tablet and ribavirin injection,respectively Evaluation was carried out with cost-effectiveness analysis RESULTS:The cost-effectiveness ratios of three groups were $1 288 2,$863 0 and $949 8 CONCLUSION:Valaciclovir was the best antiviral agents for herpes zoster

Objective:To improve the logistics management automation in hospital drugstore using internet drug supply chain coor-dination platform. Methods: According to the correspondent relationship between drug information and drug bar code, drug accept-ance, accurate location and batch input were achieved using bar code technique. Results: The platform could not only enhance the efficiency but also ensure the accuracy of drug information input. Conclusion:The platform provides a practical solution for developing modern pharmaceutical logistics and improving the efficiency of pharmaceutical distribution.

Objective To study the effect and mechanism of taspine on wound healing and fibroblast proliferation. Methods The effect of taspine on skin wound was observed in vivo. The different concentration of taspine hydrochloride was added to L929 fibroblast cultivated in vitro, and lactate dehydrogenase was detected and MTT method was applied to observe effect of taspine on fibroblast proliferation. Results The local application of taspine 3 mg/Ml and 1.5 mg/mL accelerated the healing of skin wounded. In vitro, 0.01～0.5 μg/mL of taspine hydrochloride showed no effect on the change of lactate dehydrogenase activity and fibroblast proliferation. Conclusion Taspine is a kind of active alkaloid from leontice robustum which can enhance wound healing, its mechanism on wound healing is not by means of accelerating the proliferation of fibroblast, other mechanisms are necessary for being further studied.

Objective To study the action of Shuganwan(SHGW) on experimental gastric ulcer in mice. Methods The anti-ga stric ulcer action of SHGW was observed on the gastric ulcer induced by water im mersion stress, reserpine and absolute ethyl alcohol. The effect on gastric secr etion in rats was studied by pyloric ligation. The effect on gastrointestinal mo tility was observed by gastric emptying in mice. The analgesic effect was tested by the hot-plate test and writhing method. Results SHGW m arkedly inhibited gastric ulcer induced by water immersion stress, reserpine and absolute ethyl alcohol. SHGW significantly inhibited the secretion of gastric a cid and pepsin and promoted the secretion of gastric mucus. SHGW markedly delaye d gastric emptying in normal mice and when gastric emptying was stimulated by ne ostigmine. SHGW mildly strengthend the effect of atropine on gastric emptying. S HGW enhanced hot pain threshold and decreased the number of twisting body in mic e. Conclusion Shuganwan may have anti-gastric ulcer ac tion. The mechanism of the action might be associated with its inhibition of the secretion of gastric juice, promotion of the secretion of gastric mucus,inhibit ion of activity of gastric smooth muscle and analgetic effect.