[Objective]To observe the clinical effect on peri-climacteric syndrome of kidney Yin deficiency type treated with Qinggu Powder.[Method] Select 60 cases of the type,the treatment group 30 cases were administered Qinggu Powder,the control group(30) with western medicine ethane trigamous hydroxybenzene for comparison.[Result] The treatment group had total effective rate 93.3%,compared with control one 60.0%;there’s marked difference between before and after treatment.[Conclusion] Qinggu Powder has obvious cure effect on peri-climacteric syndrome of kidney Yin deficiency type.