1.Psychological Rehabilitation for Breast Cancer(rerview)
Pilin WANG ; Qiang ZHU ; Yali SU
Chinese Journal of Rehabilitation Theory and Practice 2010;16(6):549-551
The effects of different methods of psychological treatment in psychological rehabilitation of breast cancer patients were reviewed. Group psychotherapy is the best choice of breast cancer patients for psychological rehabilitation.
3.Efficacy of Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops for Dry Eyes after Eximer Laser in-situ Keratomileusis(LASIK)
Jun LIU ; Hongling CUI ; Yali SU
China Pharmacy 2005;0(23):-
OBJECTIVE: To observe the clinical efficacy of Sodium Hyaluronate Eye Drops in combination with Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops for dry eye after undergoing eximer laser in-situ keratomileusis(LASIK).METHODS: 62 cases(100 eyes) of patients with dry eye after undergoing LASIK were randomly divided into two groups: 32 cases(53 eyes) in the treatment group were treated with Sodium Hyaluronate Eye Drops in combination with Recombinant Bovine Basic Fibroblast Growth Factor Eye Drops,and 30 cases(47 eyes) in the control group with Sodium Hyaluronate Eye Drops alone(4 times/day,1~2 drops/time) for 2 months.The drug efficacy was observed for 1~3 months since 1 week after the initiation of medication.RESULTS: The total effective rate in the treatment group vs.the control group was 98.11% vs.89.36%(P
4.Effects of Group Psychotherapy on Breast Cancer Patients
Yali SU ; Pilin WANG ; Jing CHEN ; June LIU ; Qiang ZHU
Chinese Journal of Rehabilitation Theory and Practice 2012;18(3):276-279
Objective To explore the effects of group psychotherapy on breast cancer patients. Methods 80 outpatients with breast cancerwho did not participate in the Rukang Salon (control group) and 100 outpatients participated (intervention group) were surveyed withquestionaire. Results The incidence of psychological distress was 36.8% in the control group and 21.1% in the intervention group ( χ2=5.02,P=0.03). In the intervention group, the efficacy of those without psychological distress (236.86±35.17) was significantly higher than thosewith psychological distress (214.21±26.52), (t=2.61, P=0.01). There were significant differences in those 5 factors: group cohesion, universality,interpersonal learning, guide instructions, and hope remodeling. Top 5 factors in scores reported were interpersonal learning, hopingremodeling, group cohesion, guide instructions, and exist consciousness. Conclusion Group psychotherapy can significantly reduce the psychologicaldistress in rehabilitating breast cancer patients. Group cohesion, universality, interpersonal learning, guide instructions, hope remodelingand exist consciousness may play important roles.
5.Investigation of Life Satisfaction and Related Factors in Primary Caregivers of Breast Cancer Patients
Pilin WANG ; Cuicui XUE ; Qiang ZHU ; Yali SU ; Kai HUANG
Chinese Journal of Rehabilitation Theory and Practice 2014;(2):118-120
Objective To investigate the life satisfaction and its related factors in primary caregivers of breast cancer patients. Methods The Life Satisfactory Index A (LSIA) and self-administrated questionnaire were used. The life satisfaction between breast cancer patients'primary caregivers and breast benign patients' primary caregivers were compared. The factors of the life satisfaction in primary caregivers of breast cancer patients were analyzed. Results The life satisfaction was poorer in the breast cancer patients' primary caregivers than in the breast benign patients' primary caregivers (P<0.01). The life satisfaction in the breast cancer patients' primary caregivers was correlated with the stage of breast cancer, course of disease, primary caregivers' age and family monthly income (P<0.05). Conclusion The life satisfaction in breast cancer patients' primary caregivers is worse and is related with stage of breast cancer, course of disease, primary caregivers' age and family monthly income.
6.The Expression and Clinical Significance of DKK1, SFRP4 and Wnt1 in Cervical Squamous Cell Carcinoma
Anli HOU ; Xiufen LI ; Yali ZHANG ; Dongrui YANG ; Xiaoxia SU
Tianjin Medical Journal 2013;(11):1070-1072
Objective To investigate the expressions of DKK1,SFRP4 and Wnt1 in cervical squamous cell carcino-ma(SCC), and the clinical significance thereof. Methods There were 76 samples of cervical squamous cell carcinoma were included in SCC group and 36 benign uterine resection specimens were control group (NC). The immunohistochemical meth-od was applied to detect the expressions of DKK1,SFRP4 and Wnt1 in two groups. Results The expression of DKK1 was significantly lower in SCC group than that in NC group (P<0.05). The expression levels of SFRP4 and Wnt1 were significant-ly higher in SCC group than those of NC group (P<0.05). There were significant differences in the expressions of DKK1, SFRP4 and Wnt1 between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis (P<0.05). The expression of DKK1 was negatively correlated with SFRP4 and Wnt1 in SCC group (P<0.05). The expression of SFRP4 was positively correlated with Wnt1 in SCC group (P<0.05). Conclusion The roles of SFRP4 and Wnt1 are syn-ergistic interactions in the development of SCC. DKK1 is an inhibiting factor of SCC.
7.Impact of galectin-1 expression on LoVo cell apoptosis
Huasheng TONG ; Yali ZHANG ; Bo JIANG ; Lei SU
Chinese Journal of General Surgery 1997;0(04):-
Objective To observe the changes of LoVo cell growth by galectin-1.Methods Eukaryotic expression vector of galectin-1 was constructed and transfected into LoVo cells using lipofectamineRM 2000.Immunochemistry was employed to detect galectin-1 expresson.LoVo cell proliferation and apoptosis were observed.Results Galectin-1 eukaryotic expression vector pEGFP-C1/GAL1 was successfully constructed.Three cell clones,p-GAL1-LoVo and p-LoVo,transfected with pEGFP-C1/GAL1 and pEGFP-C1 correspondingly,and LoVo were cultured successfully.Galectin-1 expression downregulated Bcl-2 level only occurring in p-GAL1-LoVo cells.p-GAL1-LoVo cell proliferation was similar to p-LoVo and LoVo cells,but p-GAL1-LoVo cell apoptosis was increased(9.61?0.56)%,as compared with p-LoVo and LoVo cells,[(3.56?0.53)% and(3.46?0.46)% respectively](P
8.Construction of RNAi recombinant vector of galectin-1 and establishment of LST-R1 cell lines stably transfected by the recombinant vector
Huasheng TONG ; Yali ZHANG ; Bo JIANG ; Lei SU
Medical Journal of Chinese People's Liberation Army 1982;0(03):-
Objective To construct the RNA interference (RNAi) eukaryotic expression vectors of galectin-1, and establish the LST-R1 cell lines stably transfected by RNAi vectors. Methods Two pairs of small interfering RNAs (siRNA) targeting to galectin-1 mRNA (GenBank: NM002305) were designed. The corresponding single-strand short hairpin interfering RNAs (shRNA), containing BamH Ⅰ, Hind Ⅲ sites and a 9nt hairpin structure, was synthesized and annealed. The annealed product and the linear eukaryotic expression plasmid pSuperior-puro, which were digested with Bgl Ⅱ and Hind Ⅲ, were ligated by T4 ligase to set up the interfering system. The recombined plasmid was identified with EcoR Ⅰand Hind Ⅲ enzyme digestion and sequencing, and co-transfected to LST-R1 cells with pcDNA6/TR with Lipofectamine2000. Positive clones were selected with 0.8?g/ml puromycin. After incubated with 4?g/ml tetracyclin for 48 hours, RT-PCR, Western blotting and immunochemistry were employed to determine galectin-1 mRNA and protein levels. Results Sequencing results suggested that the nucleotide sequence and read frame of RNAi eukaryotic exprssion vector of galectin-1, p-shRNA1 and p-shRNA2 were perfect. Stably transfected LST-R1 cell lines of p-shRNA1-LST and p-shRNA2-LST were established. The relative values of galectin-1 expression in LST-R1 cells, p-shRNA1-LST cells, p-shRNA2-LST cells and p-LST cells by RT-PCR were 0.616, 0.298, 0.373 and 0.641, respectively, and 1.00, 0.07, 0.38 and 0.97 by Western blotting. The p-shRNA1 gave the best interfering effect, which was in conformity with the results of immunochemistry measurement. Conclusions RNAi eukaryotic expression vector of galectin-1 mRNA has been successfully constructed. Establishment of the stably transfected LST-R1 cell lines may lay a foundation to explore the roles of galectin-1 in laterally spreading tumor.
9.Comparative analysis of nursing adverse events between psychiatric and general departments with SHEL model
Caiwen ZHU ; Yali WANG ; Changquan HUANG ; Qiong GUO ; Na SU ; Yuxiu WANG ; Lihua ZHANG
Chinese Journal of Practical Nursing 2011;27(10):58-61
Objective To compare and analyze the causes that occurred in psychiatric and general department using SHEL models, in order to provide evidence of preventing nursing adverse events.Methods We analyzed causes of 136 nursing adverse events using SHEL models, and compared the classification, causes, incidence of nursing adverse events between psychiatric and general departments. Results The first three nursing adverse events in psychiatric department were medication error,going outside, suicide and self harm, and those in general department were medication errors, specimens being wrong, improper operation and pipeline off. 91.18% of nursing adverse events accounted for quality of nursing services, 43.38% accounted for nursing environment, 41.18% accounted for clinical environment,and 57.35% accounted for parties and others. Incidence of nursing adverse events in psychiatric department were higher than that in general department. Conclusions SHEL model can objectively and comprehensively analyze the causes of nursing adverse events, and make nursing managers take the appropriate management strategy and the best safeguard against the risk of development of response.
10.Effects of Large Group Psychological Intervention on Coping Style of Patients with Breast Cancer
Pilin WANG ; Qiang ZHU ; Cuicui MIAO ; Yali SU ; Meng ZHAO ; Lin WANG
Chinese Journal of Rehabilitation Theory and Practice 2014;20(11):1074-1076
Objective To explore the effect of large group psychological intervention mode on coping style of patients with breast cancer.Methods 420 patients with breast cancer participated in the Rukang Salon, a large group psychological intervention, were investigated with the Simplified Coping Style Questionnaire and self-administrated questionnaire before and after intervention, respectively. Results The score of coping style of the patients significantly improved after the intervention (P<0.01). Conclusion It is effective in the large group psychological intervention on coping style of patients with breast cancer, more often in positive coping style and less in negative coping style.