Objective:To investigate the therapeutic effect of Yinzhihuang oral liquid combined with probiotics on neonatal jaundice and its effect on cellular immune function, total bilirubin, transferrin (TRF) and C-reactive protein (CRP).Methods:From September 2018 to September 2019, 134 cases of neonatal jaundice admitted to Ningbo Yinzhou People's Hospital were selected, and they were randomly divided into observation group and control groupaccording to the random digital table method, with 67 cases in each group.The control group was treated with Bacillus subtilis, and the observation group was treated with Yinzhihuang oral liquid on the basis of the control group.After 5 days of continuous treatment, the curative effect and the changes of each index were evaluated in the two groups.The therapeutic effect, the time of defecation and defecation, the cellular immune function, total bilirubin, TRF and CRP levels before and after treatment were compared between the two groups.Results:The total effective rate of the observation group (100.00%) was higher than that of the control group (91.05%) (χ 2=4.362, P<0.05). The defecation time of the observation group was (38.49±5.42)h, which was shorter than that of the control group [(64.37±7.81)h], and the defecation times of the observation group was(6.58±1.32)times/d, which was more than that of the control group [(3.82±1.08)times/d], the differences were statistically significant( t=22.384, 13.246, all P<0.05). The CD 3+ [(65.42±1.72)%], CD 4+ [(39.83±2.63)%] and CD 4+ /CD 8+ (1.46±0.10) in the observation group were higher than those in the control group [(62.19±1.54)%, (34.25±1.98)% and (1.27±0.13)] ( t=11.452, 13.874, 9.482, all P<0.05). The total bilirubin [(62.73±13.25)μmol/L] and CRP [(8.97±1.56)mg/L] in the observation group were lower than those in the control group [(117.48±22.39)μmol/L and (12.64±2.10)mg/L], while the TRF [(1.89±0.21)g/L] was higher than that in the control group [(1.59±0.16)g/L], the differences were statistically significant( t=17.225, 9.301, 11.483, all P<0.05). Conclusion:Yinzhihuang oral liquid combined with Bacillus subtilis in the treatment of neonatal jaundice has obvious effect.It can improve the cellular immune function, reduce the level of total bilirubin and CRP, and improve the level of TRF.