Objective To assess the effects of high pressure and low pressure vacuum drainage for breast cancer patients after surgery. Methods We searched the Cochrane Database of Systematic Reviews (February, 2014), MEDLINE (1983 to 2014), EMbase (1989 to 2014), CBMdisc(1978 to 2014) and Wanfang database (2001 to 2014) to collect randomized controlled trials. Three review authors independently determined the eligibility of each study. Data were extracted and Meta analyses were conducted for the eligible RCTs.
Results Six RCTs including 513 participants were identified. Six RCTs indicated that the high pressure vacuum drainage reduced the seroma formation of breast cancer patients after surgery ( OR =0. 31; 95%CI 0. 12-0. 83,P=0. 02), and could reduce the incidence of skin flap necrosis, local infection, the amount of drainage, shorten the time of hospital stay. Conclusions High pressure vacuum drainage provide an effective way after breast cancer surgery by reducing the seroma formation.

Objective:To investigate the effect of vagus nerve stimulation (VNS) on serum cytokines and neurotransmitters in epilepsy patients with depression.Methods:From March 2015 to 2018, 13 patients with epilepsy combined with depression undergoing VNS surgery in Brain Hospital of Hunan Province were selected as the research objects. The surgical efficacy, depression degree, serum cytokines and neurotransmitter changes before operation, 6 months and 12 months after operation were compared.Results:The effective rate of epilepsy treatment at 6 and 12 months after VNS were 61.5%(8/13) and 76.9%(10/13), respectively. After 6 months and 12 months, Hamiton Depression scale (HAMD) and self-rating depression scale (SDS) scores were significantly lower than those before operation ( P<0.05 or P<0.01). At 6 months after operation, serum 5-hydroxytryptamine (5-HT) level was significantly higher than that before operation, while serum interleukin (IL)-1α, IL-6 and tumor necrosis factor α (TNF- α) were significantly lower than those before operation ( P<0.05 or P<0.01). At 12 months after operation, 5-HT and dopamine (DA) were significantly increased, while IL-1 α, IL-2, IL-6 and TNF -α were significantly decreased ( P<0.05 or P<0.01). Conclusions:VNS may can improve epilepsy and depression by regulating the level of neurotransmitter and serum cytokines.