ObjectiveTo observe the therapeutic effects of Qishao Huoxue prescription on patients with lumbar disc herniation due to Qi stagnation and blood stasis and the effects of this prescription on hemorheological parameters and serum levels of inflammatory mediators. MethodA total of 86 patients with lumbar disc herniation due to Qi stagnation and blood stasis treated in the Wangjing Hospital of China Academy of Chinese Medical Sciences from January 2023 to February 2024 were selected and assigned according to the random number table into observation and control groups （n=43）. Patients in both groups received lumbar traction treatment. In addition， the observation group was orally treated with Qishao Huoxue prescription and the control group with celebrex for 3 weeks. The visual analogue scale （VAS） score， Oswestry disabilitiy index （ODI） score， 12-item Short-Form Survey （SF-12） score， traditional Chinese medicine （TCM） symptom score， hemorheological parameters ［whole blood high shear viscosity， middle shear viscosity， low shear viscosity， plasma viscosity （PV）， and fibrinogen （FIB）］， and the serum levels of inflammatory mediators ［tumor necrosis factor-α （TNF-α）， interleukin-6 （IL-6）， interleukin-1β （IL-1β）， and transforming growth factor-β₁ （TGF-β₁）］ were determined before and after treatment. In addition， the clinical efficacy and adverse reactions were observed and compared between the two groups. ResultAfter treatment， both groups showed declined VAS， ODI， and TCM symptom scores （P<0.05）， increased SF-12 physical component summary （PCS） and mental component summary （MCS） scores （P<0.05）. After treatment， the whole blood high shear viscosity， middle shear viscosity， low shear viscosity， PV， and FIB decreased in the observation group （P<0.05）， while they did not show significant variations in the control group. After treatment， both groups of patients showed reductions in TNF-α， IL-6， and IL-1β levels and an elevation in the TGF-β₁ level （P<0.05）. Compared with the control group after treatment， the observation group showed decreases in VAS， ODI， TCM symptom scores and main symptom scores （P<0.05）， no significant differences in the secondary symptom scores， increased PCS and MCS scores （P<0.05）. The observation group outperformed the control group in terms of recovering whole blood high shear viscosity， middle shear viscosity， low shear viscosity， PV， FIB， TNF-α， IL-6， IL-1β， and TGF-β₁ （P<0.05）. The total response rate in the observation group was 97.5% （40/41）， which was higher than that （88.1%， 37/42） in the control group （P<0.05）. No serious adverse reaction was observed in the two groups during the observation period. One case in the observation group showed subcutaneous bruising on the lower limbs， which gradually disappeared after withdrawal. ConclusionQishao Huoxue prescription demonstrated definite effect in treating lumbar disc herniation due to qi stagnation and blood stasis by recovering hemorheological parameters and inhibiting the expression of inflammatory mediators in the serum without inducing adverse reactions. It is worth applying in clinical practice.

Background::Histological healing is closely associated with improved long-term clinical outcomes and lowered relapses in patients with ulcerative colitis (UC). Here, we developed a novel diagnostic criterion for assessing histological healing in UC patients.Methods::We conducted a retrospective cohort study in UC patients, whose treatment was iteratively optimized to achieve mucosal healing at Shanghai Tenth People’s Hospital of Tongji University from January 2017 to May 2022. We identified an inflammatory cell enumeration index (ICEI) for assessing histological healing based on the proportions of eosinophils, CD177 + neutrophils, and CD40L + T cells in the colonic lamina propria under high power field (HPF), and the outcomes (risks of symptomatic relapses) of achieving histological remission vs. persistent histological inflammation using Kaplan-Meier curves. Intrareader reliability and inter-reader reliability were evaluated by each reader. The relationships to the changes in the Nancy index and the Geboes score were also assessed for responsiveness. The ICEI was further validated in a new cohort of UC patients from other nine university hospitals. Results::We developed an ICEI for clinical diagnosis of histological healing, i.e., Y = 1.701X 1 + 0.758X 2 + 1.347X 3 - 7.745 (X 1, X 2, and X 3 represent the proportions of CD177 + neutrophils, eosinophils, and CD40L + T cells, respectively, in the colonic lamina propria under HPF). The receiver operating characteristics curve (ROC) analysis revealed that Y <-0.391 was the cutoff value for the diagnosis of histological healing and that an area under the curve (AUC) was 0.942 (95% confidence interval [CI]: 0.905-0.979) with a sensitivity of 92.5% and a specificity of 83.6% ( P <0.001). The intraclass correlation coefficient (ICC) for the intrareader reliability was 0.855 (95% CI: 0.781-0.909), and ICEI had good inter-reader reliability of 0.832 (95% CI: 0.748-0.894). During an 18-month follow-up, patients with histological healing had a substantially better outcome compared with those with unachieved histological healing ( P <0.001) using ICEI. During a 12-month follow-up from other nine hospitals, patients with histological healing also had a lower risk of relapse than patients with unachieved histological healing. Conclusions::ICEI can be used to predict histological healing and identify patients with a risk of relapse 12 months and 18 months after clinical therapy. Therefore, ICEI provides a promising, simplified approach to monitor histological healing and to predict the prognosis of UC.Registration::Chinese Clinical Trial Registry, No. ChiCTR2300077792.

Objective To observe the impact of semi-solidification enteral nutrition on feeding tolerance,nutritional and infection related indicators,and prognosis in neurocritical patients.Methods Adopting the prospective research method,the neurocritical patients who were admitted to the department of intensive care unit(ICU)of the First Affiliated Hospital of Ningbo University from December 2021 to May 2022 and had to stay in the nasogastric tube for enteral nutrition were selected as the study subjects,pectin was added to achieve the semi-solidification of enteral nutrition,and the patients were divided into pectin group and control group according to the principle of randomized control,with 25 cases in each group.Enteral nutrition was started within 24-48 hours of admission to the ICU in all patients,and pectin plus continuously pumped enteral nutrition preparation was given in the pectin group and continuously pumped enteral nutrition preparation in the control group,all of which was used continuously for more than 7 days.Differences in albumin,prealbumin,Glasgow coma scale(GCS),acute physiology and chronic health evaluation Ⅱ(APACHEⅡ),sequential organ failure assessment(SOFA),procalcitonin(PCT),interleukin-6(IL-6)and C-reactive protein(CRP)were compared between the two groups before and after 7 days of treatment,and enteral nutrition compliance rates at 3 days and 7 days of treatment,as well as the incidence of enteral nutrition intolerance(including vomiting,diarrhea,constipation,aspiration and bloating),along with the length of ICU stay and 28 days prognosis were observed.Results There were no statistically significant differences between the two groups in general clinical data[including gender,age and body mass index(BMI)]and pre-treatment GCS score,APACHEⅡ score,SOFA score,albumin,prealbumin,PCT,IL-6 and CRP levels.The incidence of vomiting,diarrhea,constipation,and bloating during enteral nutrition was significantly lower in the pectin group than those in the control group[vomiting:4.0％(1/25)vs.24.0％(6/25),diarrhea:8.0％(2/25)vs.32.0％(8/25),constipation:20.0％(5/25)vs.65.0％(13/25),bloating:12.0％(3/25)vs.36.0％(9/25),all P<0.05],but the difference in the incidence of aspiration compared with the control group was not statistically significant[4.0％(1/25)vs.16.0％(4/25),P>0.05].Caloric compliance with enteral nutrition was significantly higher in the pectin group than in the control group at both 3 days and 7 days of treatment[3 days of treatment:48.0％(12/25)vs.20.0％(5/25),7 days of treatment:88.0％(22/25)vs.60.0％(15/25),both P<0.05],and the prealbumin level was significantly higher in the pectin group than in the control group at the end of 7 days treatment(mg/L:248.08±43.99 vs.221.64±33.95,P<0.05).There was no statistically significant difference in the comparison of GCS score,APACHEⅡ score,SOFA score,PCT,IL-6,CRP,length of ICU stay,and 28 days mortality between the two groups after treatment.Conclusion The administration of semi-solidification enteral nutrition reduces the incidence of enteral nutrition intolerance,improves caloric intake and nutritional status in neurocritical patients,but has no significant effect on infection indicators and prognosis.

Objective: Traditional uterine manipulator is considered as the main reason for short survival of patients with early-stage cervical cancer during minimally invasive surgery. This study aims to assess the sealing effect of magnetic-sealing uterine manipulators (MUMs) in isolated uteruses. Methods: The study was performed on isolated uterus from patients with early-stage cervical cancer who underwent open abdominal radical hysterectomy between November 2019 to April 2021. Right-angle forceps closure tests (groups 1 and 3) were defined as control tests. One experimental MUM closure test (group 2) and 2 control tests were respectively carried out in each of the isolated uterus. DNA ploidy analysis system was used to observe exfoliated cells. Statistical analysis was performed using Wilcoxon signed-rank test to assess the sealing effect of MUM. Results: We identified 36 patients. No regional node metastasis was discovered and only one tumor was larger than 4.0 cm in diameter. The mean of exfoliated tumor cells in groups 1, 2, and 3 were 1, 1, and 2, respectively. There was no significant difference in the quantity of exfoliated cells between groups 1 and 3 (p=0.476), so the results of the 2 groups were merged. Subsequently, a significant difference was observed between combined right-angle forceps closure tests and MUM closure tests (p=0.022). Conclusion The sealing effect of MUM was better than that of right-angle forceps. MUM can effectively seal cervical cancer cells in the cup cover, avoiding the dissemination of tumor cells.

Ovarian cancer is the most fatal malignant tumor in female reproductive system tumors.In most women, it is diagnosed in a late stage, which largely leads to the poor prognosis of ovarian cancer.Breast cancer susceptibility gene (BRCA) is an important DNA homologous repair gene, which plays a major role in the normal cellular DNA repair mechanism.Its mutation will lead to homologous recombination defects, which will affect the stability of the genome and lead to occurrence of tumors.In recent years, BRCA genetic testing has become a key step in the risk assessment, prognosis, treatment and prevention of ovarian cancer.

Objective:To investigate the relationship between metabolic syndrome (MS) and the risk of breast cancer in Chinese females.Methods:From May 2006 to December 2015, based on the Kailuan Women′s Dynamic Cohort,a total of 25 618 female employees and retirees of the Kailuan Group were included and followed. Questionnaire surveys, physical measurements and laboratory tests were used to collect baseline sociodemographic characteristics, height, weight, blood glucose, blood lipids, blood pressure, tumor incidence and outcome information. Cox proportional hazards regression models were used to analyze the relationship between MS and its components (body mass index, blood pressure, blood glucose and blood lipid) and the risk of breast cancer in females.Results:The age of 25 618 women was (47.65±12.02) years old and median follow-up time was 8.78 years; 235 new cases of breast cancer were detected, and the incidence density was 113.19/100 000 person-years. After adjusting for age, education, income, smoking status, drinking status and other factors, people who were overweight or obese had a higher risk of breast cancer, with HR (95% CI) about 1.47 (1.12-1.93), than those with normal body mass index. Compared with those without MS abnormal components, women with two MS abnormal components had an increased risk of breast cancer ( HR=1.70, 95% CI: 1.16-2.50). With the increase of the number of MS abnormal components, the risk of breast cancer increased gradually ( Ptrend value<0.05). Conclusion:Overweight/obesity and the number of abnormal components of MS can increase the risk of breast cancer in women.

Objective:To investigate the relationship between metabolic syndrome (MS) and the risk of breast cancer in Chinese females.Methods:From May 2006 to December 2015, based on the Kailuan Women′s Dynamic Cohort,a total of 25 618 female employees and retirees of the Kailuan Group were included and followed. Questionnaire surveys, physical measurements and laboratory tests were used to collect baseline sociodemographic characteristics, height, weight, blood glucose, blood lipids, blood pressure, tumor incidence and outcome information. Cox proportional hazards regression models were used to analyze the relationship between MS and its components (body mass index, blood pressure, blood glucose and blood lipid) and the risk of breast cancer in females.Results:The age of 25 618 women was (47.65±12.02) years old and median follow-up time was 8.78 years; 235 new cases of breast cancer were detected, and the incidence density was 113.19/100 000 person-years. After adjusting for age, education, income, smoking status, drinking status and other factors, people who were overweight or obese had a higher risk of breast cancer, with HR (95% CI) about 1.47 (1.12-1.93), than those with normal body mass index. Compared with those without MS abnormal components, women with two MS abnormal components had an increased risk of breast cancer ( HR=1.70, 95% CI: 1.16-2.50). With the increase of the number of MS abnormal components, the risk of breast cancer increased gradually ( Ptrend value<0.05). Conclusion:Overweight/obesity and the number of abnormal components of MS can increase the risk of breast cancer in women.

ObjectiveTo explore the application of network information platform in the standardized training of newly recruited nurses in Neurology Department and evaluate its effect. MethodsA total of 34 new nurses recruited by Beijing Tiantan Hospital affiliated to Capital Medical University in 2017 were selected as intervention group and trained through network information platform. A total of 38 newly recruited nurses from Neurology Department of the same hospital from 2015 to 2016 were selected as the control group and trained by routine training methods. The clinical nursing ability, specialty theory results and specialty skills results of the two groups of newly recruited nurses were compared. ResultsIn the intervention group, the self-evaluation leadership of newly recruited nurses was (11.23±1.79), the monitoring of critical patients was (21.56±2.78), the teaching and cooperation was (28.97±4.11), the planning and evaluation was (21.18±2.89), the communication and exchange was (31.82±3.75), the professional development was (32.08±3.54) and the total score was (146.8±6.72). The scores of the above items in the control group were (9.87±1.72), (19.13±2.61), (26.79±3.92), (19.68±2.95), (28.66±3.54), (30.00±3.94) and (134.13±7.25) respectively. There were significantly statistical differences between the two groups (t=-7.69 - -2.16; P＜ 0.05). In the intervention group, the peer evaluation leadership of newly recruited nurses was (10.23±1.79), the monitoring of critically ill patients was (20.97±2.77), the teaching and cooperation was (28.35±4.01), the planning and evaluation was (20.68±2.98), the communication and exchange was (31.47±3.54), the professional development was (31.64±3.33) and the total score was (143.36±6.39). The scores of the control group were (8.71±1.58), (18.07±2.36), (25.76±3.97), (19.08±3.03), (27.61±3.61), (28.55±4.07) and (127.79±6.73). There were significantly statistical differences between the two groups (t= -10.03 - -2.25; P ＜ 0.05). In the control group, the excellence rate and good rate of theoretical knowledge were 13.2%(5/38) and 36.8%(14/38) respectively, and the excellence rate and good rate of professional skills results were 10.5%(4/38) and 55.3%(21/38) respectively. In the intervention group, the excellence rate and good rate of theoretical knowledge were 23.5% (8/34) and 47.0%(16/34) respectively, and the excellence rate and good rate of professional skills results were 20.6%(7/34) and 58.8%(20/34) respectively. The academic and professional skills scores of the intervention group were higher than those of the control group with statistical difference (Z=-2.902, -2.908; P＜ 0.01). ConclusionsApplying the network information platform to standardize the training for newly recruited nurses in neurology department can improve their clinical nursing ability, the results of professional theoretical and practical skills.

Objective? To explore the incidence of subsyndromal delirium (SSD) in ICU patients after surgery for craniocerebral tumor and its influencing factors. Methods? Totally 100 patients admitted in the General Intensive Care Unit of a ClassⅢ Grade A hospital in Beijing between January and December 2018 were selected. Confusion Assessment Model for Intensive Unit (CAM-ICU) was used to assess the incidence of SSD in these patients on a daily basis. Their clinical data, including general information, vision and listening, Mini-Mental State Examination (MMSE) scores, Acute Physiology and Chronic Health Evaluation Scoring System (APACHEⅡ) scores, mechanical ventilation, restraints, oxygenation index, albumin, hemoglobin, Na+, Cl-, K+ and Ca2+ values until they were transferred out of ICU. Univariate analysis was employed to screen the possible risk factors, and unconditional Logistic stepwise regression analysis was used to identify the independent risk factors of SSD in ICU patients. Results? The incidence rate of SSD in the 100 ICU patients after surgery for craniocerebral tumor was 40%(40/100), and 55.0%(22/40) of the patients sustained SSD since day 1-3 after admission into ICU. The average frequency of incidence was 2.08 times, and it lasted (30.80±10.11) h. Logistic regression analysis revealed that infection, pain, APACHE II scores were the independent predictive factors for SSD in ICU patients after surgery for craniocerebral tumor (P＜0.05). Conclusions? The incidence rate of SSD in ICU patients after surgery for craniocerebral tumor is high, and infection, pain and high APACHE Ⅱ scores are likely to lead to SSD.

Objective? To explore the status quo of subsyndromal delirium (SSD) in surgical intensive care unit (ICU) patients and to analyze its influencing factors. Methods? Totally 135 surgical ICU patients admitted in a Class Ⅲ Grade A hospital in Beijing from June 2016 to February 2017 were selected. Confusion Assessment Model for Intensive Care Unit (CAM-ICU) was used to evaluate the morbidity of SSD on a daily basis. The patients' general information, vision and hearing conditions, Mini-Mental State Examination (MMSE) scores, Acute Physiology and Chronic Health Evaluation Scoring System (APACHEⅡ) scores, mechanical ventilation, constraints, oxygenation index and laboratory measurements such as blood albumin, hemoglobin, Na+, Cl-, K+, Ca2+ and other data were collected until they were transferred from ICU. Univariate analysis was used to analyze potential risk factors, and unconditioned Logistic regression analysis was used to analyze the independent risk factors of SSD in surgical ICU patients. Results? The morbidity rate of SSD was 34.1% (46/135), and the morbidity rate of delirium was 28.9% (39/135). According to univariate analysis, there was statistically significant difference in age, educational background, marital status, operation or not, APACHEⅡscores, MMSE scores, use of constraints, use of mechanical ventilation, and incidence of hypoproteinemia or hyponatremia between patients with SSD and without SSD (P＜0.05). Logistic regression analysis revealed that MMSE, hypoproteinemia and constraints were independent prognostic factors affecting the incidence of SSD in surgical ICU patients (OR=0.848, 3.325, 3.393; P＜ 0.05). Conclusions? The incidence rate of SSD in surgical ICU patients is high. Patients with lower MMSE scores, hypoproteinemia and use of constraints are more susceptible to SSD.